Regulation and biological impact of IL-17 production by gamma delta T cells

点击翻译按钮获取中文摘要

Program Director/Principallnvestigator (Last, First, Middle): Chien, Yueh-Hsiu Program Director/Principal Investigator (Last, First, Middle): Chien, Yueh-Hsiu 1 R01 A1080829-O1AI I ROl AI080829-01 A 1 ABSTRACT Inflammation is a rapid response to tissue damage and/or infection. While it is largely an innate Inflammation a rapid response to tissue damage infection. While is largely an innate response during its initial stages, in vertebrates, it has evolved to require a T ceU cytokine, IL-17, in it has evolved to require a T cell cytokine, to promote the expansion of neutrophils and monocytes in the bone marrow and their release and recruitment to sites of inflammation. This process strengthens the inflammatory cascade to to sites inflammation. This process strengthens the inflammatory cascade to signal, eradicate the injurious signal, starts the resolution program and launches the adaptive immune (U) =w' response. Our previous experiments suggested that El EIIT cellsare uniquely suited to mount an experiments suggested that 0 I;J T cells are uniquely suited to mount an response. IL-17 response at the onset of acute inflammation and we found that E1II1J cells are the major ILonset of acute inflammation and we found that DCTr cells are the IL IL-17 17+ population at the onset of CFA immunization.. While the development of IL-i 7f Li LIT cells has immunization the development of IL-17:tDI;J T cells 17+ population regulated in DI;:JT been well documented, little is known about how IL-17 is regulated in[ILIT cells. Furthermore, documented, deficier)to LiT responses have been noted in although deficientLi l;JT responses have been noted in mice lackingD I;JT cells, the possibility lacking LI1T cells, the possibility thqtthese cells act early in an inflammatory response to affect the priming process has not been in thatthese priming been explored. We will investigate these areas, which are of fundamental importance in understanding explored. will areas, which fundamental in understanding host immune defense. defense. -,Q" .2) =-0 0 pay .L., E'6 --6 ,tea 0-0 ono