9th International Symposium on Bordetella

描述(由申请人提供)： 摘要 项目：1R13AI091296-01标题：第九届波氏杆菌国际研讨会登录号：3256068 = 注意：此摘要摘自应用程序，未经SRA校对。如果应用程序扫描过程有问题，提取的文本可能不正确或不完整。 = 百日咳杆菌是人类呼吸道疾病百日咳的病原体，1906年首次由Bordet和Gengou在巴斯德研究所培养，2006年在巴黎巴斯德研究所举行的国际百日咳杆菌会议包括庆祝这一重要事件的百年纪念。该属的其他重要成员，支气管败血杆菌，一种动物病原体，也可以感染免疫功能低下的人类，以及副百日咳杆菌，一种人类病原体，可以导致轻微的百日咳样疾病，分别于1912年和1938年被分离出来。美国和世界其他地区的百日咳发病率最近一直在上升，尽管积极的免疫规划覆盖面很广，2005年美国报告的病例数量是50年来的最高水平。除了最初的波氏杆菌，禽类芽孢杆菌是禽类呼吸道感染的重要原因，并对家禽养殖业造成巨大的经济损失。此外，该属的几个新种，如B.hinzii、B.holmesii、B.trematum和B.Petrii，在病谱、毒力因子和致病机理方面都不是很好的特征。百日咳杆菌、副百日咳杆菌、败血症杆菌、禽型杆菌和贝氏杆菌的基因组已经测序并公布了数据，新的基因组序列信息将在2010年出现。因此，这是一次特别及时的会议，讨论波尔德氏菌生物学中的这些和其他重要问题。这项提议要求支持学生和博士后研究员、来自代表性不足的少数群体的受训人员以及发展中国家的科学家参加2010年10月在马里兰州巴尔的摩内港文艺复兴万豪酒店举行的第九届波尔德泰拉国际研讨会。课程内容包括病因学、免疫学、基因组学、流行病学和预防与治疗。波尔德泰拉社区是一个特别开放和合作的科学家群体，重要的是保证和支持受训人员出席这样的会议，以鼓励这一领域的未来研究人员。本提案中申请旅费的会议是对百日咳杆菌和相关波氏杆菌属生物引起的疾病具有研究、临床、公共卫生和疫苗兴趣和专业知识的人的定期活动。最近，美国的百日咳病例数量达到了50年来的最高水平，一种新的疫苗配方被批准用于青少年和成年人。百日咳和相关疾病目前是美国和国际公共卫生的一个重大问题，这些疾病的所有方面都将在这次会议上得到解决。支持受训人员出席和参加会议对于培养这一领域的新调查人员至关重要。

DESCRIPTION (provided by applicant): Abstract PI: CARBONETTI, NICHOLAS H. Project: 1R13AI091296-01 Title: 9th International Symposium on Bordetella Accession Number: 3256068 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== Bordetella pertussis, the causative agent of the human respiratory disease pertussis (whooping cough) was cultured for the first time in 1906, by Bordet and Gengou, at the Institut Pasteur, and the previous International Bordetella meeting in 2006 at the Institut Pasteur in Paris included celebration of the centennial of that important event. Other important members of the genus, B. bronchiseptica, an animal pathogen that can also infect immunocompromised humans, and B. parapertussis, a human pathogen that can cause a mild pertussis-like disease, were isolated in 1912 and 1938, respectively. The incidence of pertussis has recently been increasing in the US and other parts of the world, despite active immunization programs with wide coverage, and the number of reported cases in the US in 2005 was a 50-year high. Beyond the original bordetellae, B. avium is an important cause of respiratory infections in birds and is responsible for tremendous economic losses for the poultry industry. In addition, several new species within the genus, such as B. hinzii, B. holmesii, B. trematum and B. petrii, are not well characterized with regard to spectrum of disease, virulence factors or pathogenesis. The genomes for B. pertussis, B. parapertussis, B. bronchiseptica, B. avium and B. petrii have been sequenced and the data published, and new genome sequence information will emerge in 2010. Therefore, this is a particularly timely meeting to discuss these and other important issues in Bordetella biology. This proposal is requesting support for students and post-doctoral fellows, for trainees from underrepresented minority groups and for developing world scientists to attend the 9th International Symposium on Bordetella, to be held in October 2010 at the Renaissance Marriott Hotel at the Inner Harbor, Baltimore, MD. Sessions on Pathogenesis, Immunology, Genomics, Epidemiology, and Prevention and Treatment will be included. The Bordetella community is an especially open and collaborative collection of scientists and it is important to assure and support attendance of trainees at meetings such as this, to encourage future investigators in this field. The meeting for which travel funds are being requested in this proposal is a regular event for those with research, clinical, public health and vaccine interest and expertise in diseases caused by Bordetella pertussis and related organisms in the genus Bordetella. Very recently, the number of pertussis cases in the US was at a 50-year high, and a new vaccine formulation was approved for use in adolescents and adults. Pertussis and related illnesses are currently a significant problem for US and international public health and all aspects of these illnesses will be addressed at this meeting. Support for trainees to attend and participate in the meeting is essential for development of new investigators in this field.