Systems-Level Research in Microbial Pathogenesis

微生物发病机制的系统级研究

• 批准号: 10671611
• 负责人: NICHOLAS H CARBONETTI
• 金额: $ 37.83万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10671611
• 关键词: Pathogenesis; Research; System; microbial

PROJECT SUMMARY This training program in “Systems-Level Research in Microbial Pathogenesis” will formalize and strengthen interdisciplinary research in microbial pathogenesis and high-throughput science that interrogates parasites, fungi, bacteria, and viruses more completely at the systems-level. The University of Maryland Baltimore has exceptional strength and depth in microbiology, infectious disease, vaccinology, genomics, and bioinformatics with >100 faculty with research in these areas. The nineteen senior training faculty and seven junior training faculty are drawn from the world class microbial pathogenesis research programs in the Schools of Medicine, Dentistry, and Pharmacy; including scientists from two of the university's internationally renowned research institutes—the Center for Vaccine Development and the Institute for Genome Sciences. These faculty have >1000 publications in the past ten years and 93 grants with average direct costs of $1,707,495/year. They will develop and participate in a new graduate course targeting these trainees that is aimed at interdisciplinary research at the intersection of microbial pathogenesis and systems-level research. Predoctoral trainees will be selected from two interdepartmental doctoral programs that include a common core curriculum, elective courses, journal clubs, seminars, annual symposia, and graduate research presentations. The selected predoctoral students will also include trainees from the School of Medicine MD/PhD program and the School of Dentistry DDS/PhD program. Academic work will be combined with rigorous mentored research training in the research groups of the training faculty, who have current and past training grant eligible predoctoral trainees with an average of 4.0 publications/trainee. Postdoctoral trainees will be selected through recruitment of new fellows to the University of Maryland Baltimore. Our training grant eligible postdoctoral trainees have been equally productive with 4.5 publications/trainee. The program is guided by a highly qualified team of three Co- Directors (MPIs) with two serving as track leaders, as well as an internal Executive Committee. An External Advisory Committee has also been established that will evaluate the program. Our trainees will be further focused on systems-level research in microbial pathogenesis through a change in our curriculum, as well as unique opportunities that will aid in recruitment and development of more students in this area. Programs that distinguish trainees from the larger pool of graduate students, to promote and enhance their training, include (i) oral presentations at the annual University of Maryland intercampus Crosstalk symposium, (ii) regular training program research meetings, (iii) teaching opportunities in graduate and medical courses, (iv) opportunities to present at national or international conferences, (v) opportunities to present in internal seminar series, (vi) formalized career mentoring and career-focused networking, and (vii) formal training in mentorship and mentoring an undergraduate or high school student from groups typically underrepresented in science, helping to build our robust pipeline for developing diverse scientists.

项目摘要 “微生物发病机制的系统级研究”的培训计划将正式化和加强 微生物发病机理和高通量科学的跨学科研究，询问寄生虫， 真菌、细菌和病毒在系统水平上更完整。马里兰州巴尔的摩大学 在微生物学、传染病、疫苗学、基因组学和生物信息学方面具有卓越的实力和深度 有超过100名教师在这些领域进行研究。19名高级培训教师和7名初级培训教师 教师来自世界一流的微生物发病机制研究计划在医学院， 牙科和药学;包括来自该大学两项国际知名研究的科学家 研究所--疫苗开发中心和基因组科学研究所。这些教师有 在过去十年中出版了1000多篇出版物，获得了93笔赠款，平均直接费用为1，707，495美元/年。他们将 制定并参加针对这些受训人员的新的研究生课程， 微生物发病机理和系统水平研究的交叉研究。实习生将在 从两个跨部门的博士课程，包括共同的核心课程，选修 课程，期刊俱乐部，研讨会，年度专题讨论会和研究生研究报告。所选 博士前的学生还将包括来自医学博士/博士课程和医学院的学员。 牙科DDS/博士课程。学术工作将结合严格的指导研究培训， 培训学院的研究小组，谁拥有当前和过去的培训补助金合格的博士前学员 平均每名学员发表4.0篇文章。博士后培训生将通过招聘新的 马里兰州巴尔的摩大学的研究员。我们的培训补助金合格的博士后学员已经 同样的生产力，4.5出版物/受训者。该计划是由一个高素质的团队指导的三个合作， 董事（MPI）与两个担任轨道领导人，以及一个内部执行委员会。外部 还成立了咨询委员会，对该方案进行评估。我们的学员将进一步 通过改变我们的课程，专注于微生物发病机理的系统级研究，以及 独特的机会，这将有助于招聘和发展更多的学生在这一领域。的程序 将受训人员与更大的研究生群体区分开来，以促进和加强他们的培训，包括㈠ 在年度马里兰州大学校际相声研讨会上做口头报告，（ii）定期培训 计划研究会议，（三）研究生和医学课程的教学机会，（四）机会， 出席国家或国际会议，㈤有机会参加内部系列研讨会，㈥ 正式的职业辅导和以职业为重点的网络，以及㈦正式的辅导培训， 指导来自科学领域通常代表性不足的群体的本科生或高中生，帮助 为培养多样化的科学家建立强大的管道。