Association among serum perfluroalkyl chemicals,chronic kidney disease and cardio

血清全氟烷基化学物质与慢性肾病和心脏病之间的关系

• 批准号: 7865359
• 负责人: Anoop Shankar
• 金额: $ 7.33万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-04 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7865359
• 关键词: Acids; Adult; Age; Alkanesulfonates; Appalachian Region; Blood; Body mass index; C10; Cardiovascular Diseases; Chemicals; Chronic Kidney Failure; Communities; Coronary heart disease; Creatinine; Data; Data Analyses; Diagnosis; Diet Modification; Disease; Education; Epidemiologic Methods; Equation; Ethnic Origin; Follow-Up Studies; Funding; Future; Gender; Glomerular Filtration Rate; Guidelines; Health; Health Surveys; Human; Kidney Diseases; Logistic Regressions; Measurement; Modeling; Ohio; Outcome; Physicians; Population; Race; Role; Sampling; Serum; Stroke; Study Subject; West Virginia; Woman; aged; base; cohort; cost; court; health disparity; improved; interest; member; meter; perfluorodecanoic acid; perfluorohexane; perfluorooctane sulfonate; population based; prevent; public health relevance

DESCRIPTION (provided by applicant): This proposal describes a population-based study to examine the relation of blood levels of perfluroalkyl chemicals (PFCs) to the presence of chronic kidney disease (CKD) and cardiovascular disease (CVD) in two separate studies in a population-based sample of Appalachian adults. We are requesting funding for secondary analysis of data. This proposal takes advantage of the data on exposures and outcomes already gathered on a population-based cross-sectional sample of 56,554 Appalachian adults who were aged e18 years and 53% of whom were women, residing in six communities in Ohio and West Virginia, called the C8 Health Study. In the study, we have data available on serum PFC levels, the main exposure of interest, on all members of the cohort, including serum levels of perfluorooctane sulfonate (PFOS or C8s), perfluorooctanoic acid (PFOA or C8), perfluorohexane sulfonate (PFHxS or C6S), perfluorohexanoic acid (PFHxA or C6), perfluoropentanoic acid (PFPeA or C5), perfluoroheptanoic acid (PFHpA or C7), perfluorononaoic acid (PFNA or C9), perfluorodecanoic acid (PFDA or C10), perfluoroundecanoic acid (PFUnA or C11), and perfluorododecanoic acid (PFDoA or C12) as part of a previous court-mandated health survey. We also have available pertinent data that will enable us to define CKD and CVD, the main outcomes of interest. This includes serum creatinine measurement that is available on all study subjects, enabling us to estimate glomerular filtration rate (eGFR), estimated by the Modification of Diet in Renal Disease (MDRD) equation. We will define CKD as an eGFR of <60 mL/min per 1.73 meter2, consistent with current guidelines. We also have data on validated, physician diagnosed CVD, including coronary heart disease and stroke. We will examine the putative association between serum PFCs and the outcomes of interest (CKD or CVD) employing standard epidemiological techniques, including multivariable logistic regression models adjusting for age, gender, race- ethnicity, education, body mass index, and other confounders. Our study provides a unique and cost-effective opportunity to assess the independent association between serum PFC and the presence of CVD and CKD in a large community-based cohort in Appalachia, which is a designated health disparity population. Data from our study will improve the understanding of the health effects of PFCs on humans. Results from the current study will also guide the planning of future follow-up studies of the same cohort population. PUBLIC HEALTH RELEVANCE: Perfluroalkyl chemicals (PFC) are detectable in the blood of >98% of S adults. We will study the association between blood PFCs and kidney disease and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases.

描述（由申请人提供）：该提案描述了一项基于人群的研究，以检查完美素烷基化学物质（PFC）与慢性肾脏疾病（CKD）和心血管疾病（CVD）的存在的关系中的两种单独的研究中的两种研究中，在基于人群的Appalachian成人样本中。我们要求资助数据的次要分析。该提案利用了已经收集的有关56,554名Appalachian成年人的横断面样本的暴露和成果的数据，他们年龄E18岁，其中53％是妇女，居住在俄亥俄州和西弗吉尼亚州的六个社区中，称为C8 Health研究。 In the study, we have data available on serum PFC levels, the main exposure of interest, on all members of the cohort, including serum levels of perfluorooctane sulfonate (PFOS or C8s), perfluorooctanoic acid (PFOA or C8), perfluorohexane sulfonate (PFHxS or C6S), perfluorohexanoic acid (PFHxA or C6），全氟戊酸（PFPEA或C5），全氟乙酸（PFHPA或C7），全氟众酸（PFNA或C9），全氟二烷酸，PFDA或C10），PFDA或C10），pfluoroundecanoicecanodecanodecanodecanodecanodecanodecanod c11和c11，和pfunocanod and c11 ,， pfunodecanod and c11 ,， pfunodecanoic and c11 ,， pfunodecanoic and c11 ,， （PFDOA或C12）作为先前法院授权的健康调查的一部分。我们还拥有可用的相关数据，使我们能够定义CKD和CVD，这是关注的主要结果。这包括所有研究对象都可以使用的血清肌酐测量值，使我们能够估计肾小球滤过率（EGFR），该肾脏过滤率（EGFR）通过肾脏疾病（MDRD）方程中的饮食修饰估算。我们将CKD定义为每1.73 meter2的EGFR小于60 ml/min，与当前指南一致。我们还拥有有关经过验证的医师诊断为CVD的数据，包括冠状动脉疾病和中风。我们将使用标准的流行病学技术，包括针对年龄，性别，种族种族，教育，体重指数和其他混杂因素调整的多变量逻辑回归模型，其中包括使用标准的流行病学回归模型，包括使用标准的流行病学回归模型，包括多变量的逻辑回归模型，其中包括多变量的逻辑回归模型，包括多变量的逻辑回归模型。我们的研究提供了一个独特且具有成本效益的机会，可以评估血清PFC与CVD和CKD之间在阿巴拉契亚州的大型社区人群中（这是指定的健康差异人群）中的独立关联。我们研究的数据将提高对PFC对人类健康影响的理解。当前研究的结果还将指导对同一队列人群的未来后续研究计划。 公共卫生相关性：在> 98％的S成年人的血液中可检测到全氟烷基化学物质（PFC）。我们将研究血液PFC与肾脏疾病与心血管疾病之间的关联。如果我们找到一种关联，则间接表明减少PFC可能在预防这些疾病中起作用。