Enzymology and Molecular Biology of Carbonyl Metabolism XV

羰基代谢的酶学和分子生物学 XV

• 批准号: 7916092
• 负责人: HENRY WEINER
• 金额: $ 3.07万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2010-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916092
• 关键词: Alcohol Oxidoreductases; Alcohol dehydrogenase; Collaborations; Drug Metabolic Detoxication; Enzymatic Biochemistry; Enzymes; Event; Family; Fright; Funding; Future; Gene Expression Regulation; International; Journals; Kentucky; Laboratories; Manuscripts; Metabolic Biotransformation; Metabolism; Molecular Biology; Oral; Pharmaceutical Preparations; Physiological; Positioning Attribute; Postdoctoral Fellow; Publications; Qualifying; Reaction; Research Support; Role; Scientist; Secure; Senior Scientist; Students; Xenobiotic Metabolism; aldehyde dehydrogenases; drug metabolism; enzyme mechanism; meetings; posters; public health relevance

DESCRIPTION (provided by applicant): The purpose of this R13 proposal is a requests funds for graduate and post doctoral students to attend an international meeting called Enzymology and Molecular Biology of Carbonyl Metabolism. This will be the fifteenth meeting the applicant has organized and it will be held in Lexington, Kentucky July 6-10, 2010. The three enzyme families discussed at the meeting are alcohol dehydrogenase, aldehyde dehydrogenase and carbonyl reductase. The topics range from the physiological role of the enzymes to their involvement in cellular events. Enzyme mechanism and gene regulation are discussed as well as the role of the enzymes in drug metabolism and detoxification reactions. Graduate and post doctoral students have always attended the meeting, as has an occasional undergraduate student, where they present posters while senior scientists are invited to make oral presentations. All are invited to submit a manuscript for publication in a special edition of a journal. No funds are requested to support senior scientist as each of them have to pay their own way. Because of the difficulty in securing research support it is feared that many laboratories will not be able to send qualified students to the meeting as they have in the past. Typically 25 students have attended the meeting along with 50-60 senior scientists. If stipends are available students will be able to attend this meeting where students and senior scientists interact freely and, in the past, formed many collaborations and secured future post doctoral positions. PUBLIC HEALTH RELEVANCE: The "Carbonyl" meeting is the only meeting devoted to this topic and most of the major scientists investigating the physiological and enzymological importance of carbonyl metabolism attend the meeting. The enzymes are involved in biotransformations, drug and xenobiotic metabolism. The purpose of the proposal is to obtain funds to support graduate and post doctoral student participation at this international meeting.

描述（由申请人提供）：本R13提案的目的是为研究生和博士后学生申请资金，以参加一个名为羰基代谢酶学和分子生物学的国际会议。这将是申请人组织的第十五次会议，会议将于2010年7月6日至10日在肯塔基州的列克星敦举行。会上讨论的三个酶家族是醇脱氢酶、醛脱氢酶和羰基还原酶。主题范围从酶的生理作用到它们参与细胞活动。酶机制和基因调控以及酶在药物代谢和解毒反应中的作用进行了讨论。研究生和博士后学生总是参加会议，偶尔也会有本科生参加，他们在那里展示海报，而资深科学家则被邀请做口头报告。所有人都被邀请提交一份手稿，以便在一份期刊的特刊上发表。没有要求为支持高级科学家提供资金，因为他们每个人都必须支付自己的费用。由于难以获得研究支持，人们担心许多实验室将无法像过去那样派遣合格的学生参加会议。通常有25名学生沿着50-60名资深科学家参加会议。如果助学金是可用的学生将能够参加这次会议，学生和资深科学家自由互动，并在过去，形成了许多合作，并确保未来的博士后职位。 公共卫生关系：“羰基”会议是专门讨论这一主题的唯一会议，大多数研究羰基代谢的生理学和酶学重要性的主要科学家都参加了会议。这些酶参与生物转化、药物和异生物质代谢。该提案的目的是获得资金，以支持研究生和博士后学生参加这次国际会议。

项目成果

Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.

• DOI: 10.1016/j.cbi.2011.02.016
• 发表时间: 2011-05-30
• 期刊: CHEMICO-BIOLOGICAL INTERACTIONS
• 影响因子: 5.1
• 作者: Brocker, Chad;Cantore, Miriam;Failli, Paola;Vasiliou, Vasilis
• 通讯作者: Vasiliou, Vasilis

Inactivation of porcine kidney betaine aldehyde dehydrogenase by hydrogen peroxide.

过氧化氢灭活猪肾甜菜碱醛脱氢酶。

• DOI: 10.1016/j.cbi.2011.01.030
• 发表时间: 2011
• 期刊: Chemico-biological interactions
• 影响因子: 5.1
• 作者: Rosas-Rodriguez,JesusA;Valenzuela-Soto,ElisaM
• 通讯作者: Valenzuela-Soto,ElisaM

Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol.

• DOI: 10.1016/j.cbi.2010.12.017
• 发表时间: 2011-05-30
• 期刊: CHEMICO-BIOLOGICAL INTERACTIONS
• 影响因子: 5.1
• 作者: Endo, Satoshi;Matsunaga, Toshiyuki;Ohta, Chisato;Soda, Midori;Kanamori, Ayano;Kitade, Yukio;Ohno, Satoshi;Tajima, Kazuo;El-Kabbani, Ossama;Nara, Akira
• 通讯作者: Nara, Akira

Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.

人羰基还原酶 1 和 3 还原 S-亚硝基谷胱甘肽的研究。

• DOI: 10.1016/j.cbi.2011.01.016
• 发表时间: 2011
• 期刊: Chemico-biological interactions
• 影响因子: 5.1
• 作者: Staab,ClaudiaA;Hartmanova,Tereza;El-Hawari,Yasser;Ebert,Bettina;Kisiela,Michael;Wsol,Vladimir;Martin,Hans-Jorg;Maser,Edmund
• 通讯作者: Maser,Edmund

Steroid degradation and two steroid-inducible enzymes in the marine bacterium H5.

• DOI: 10.1016/j.cbi.2011.01.027
• 发表时间: 2011-05
• 期刊: Chemico-biological interactions
• 影响因子: 5.1
• 作者: Y. Sang;G. Xiong;E. Maser