A comprehensive analysis of the role of the Alcohol Dehydrogenase gene cluster in alcohol-related disorders and esophageal cancer through deep resequencing

通过深度重测序全面分析酒精脱氢酶基因簇在酒精相关疾病和食管癌中的作用

• 批准号: nhmrc : 1060663
• 负责人: Dr Allan Mcrae
• 金额: $ 40.36万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/comprehensive-analysis-role-deep-resequencing/454843
• 关键词: comprehensive; analysis; role; Alcohol; Dehydrogenase

Excessive alcohol consumption remains a major public health concern in Australia where the burden of mental health disorders is dominated by substance-use disorders. Alcohol dehydrogenases (ADHs) are essential in the breakdown of alcohol in the body and we seek to resequence seven ADH genes with the aim to comprehensively catalogue and identify sequence variants that contribute to risk for consuming excessive quantities of alcohol, alcoholism and esophageal squamous cell carcinoma.

在澳大利亚，过度饮酒仍然是一个主要的公共卫生问题，精神健康障碍的负担主要是药物使用障碍。酒精脱氢酶（ADHS）对于体内酒精的分解至关重要，我们寻求对七个ADHS基因进行重新测序，旨在全面编目和识别导致过量饮酒、酗酒和食道鳞状细胞癌风险的序列变体。