2010 Chemotactic Cytokines Gordon Research Conference

描述(申请人提供)：20年前，趋化因子被定义为一种功能和生化上截然不同的蛋白质家族。在这段时间里，该家族已经从少数成员扩大到目前的情况，已经确定了近50种趋化因子。在这中间的几年里，在描述趋化因子的结构、识别它们的受体以及解开它们参与的复杂生物学方面取得了很大进展。这些研究的结果表明，趋化因子及其受体在“免疫”组织器官发生以及先天和适应性免疫反应的协调中起着关键作用。因此，趋化因子生物学现在支撑着一系列广泛的生物学专业。重要的是，“转化性”研究为趋化因子及其受体在一系列重要病理中的重要性提供了无可争辩的证据。因此，从本质上讲，所有免疫和炎症性疾病的心脏在趋化因子或趋化因子受体的表达或反应方面都存在某种功能障碍。此外，两种趋化因子受体(CCR5和CXCR4)通过作为病毒进入的辅助受体在HIV的发病机制中发挥着深远的作用。最后，关于趋化因子及其受体在癌症和癌症转移中的作用的细节，为协调复杂的肿瘤发生过程提供了重要的见解。重要的是，这些以病理学为重点的研究突出了趋化因子及其受体作为重要的治疗靶点，这一领域10多年的工作现在反映在一些趋化因子受体阻滞剂被批准用于临床。因此，在“趋化细胞因子”上，戈登会议将探索趋化因子及其受体的复杂和多样化的生物学，并将其与对这些分子的调节的最新理解相结合。此外，我们将审查最新的治疗发展，并将提供基于趋化因子的治疗的临床进展的最新情况。我们希望，这将是一次前瞻性会议，有机会深入分析我们的实地今后的发展方向。重要的是，这可能是2008至2012年间唯一一次以趋化因子为重点的国际会议，因此对该领域具有根本性的重要性。血细胞在全身的运动是我们抵抗感染和修复受伤组织能力的关键，这种运动由称为趋化因子的特殊分子控制。此外，现在已知趋化因子在许多疾病的发展中起重要作用，如自身免疫性疾病、艾滋病毒感染和癌症。申请中申请的资金将部分用于支持一次国际会议，趋化因子研究领域的国际领导人将在会上齐聚一堂，分享他们的数据和经验。

DESCRIPTION (provided by applicant): It is 20 years since the definition of chemokines as a functionally and biochemically distinct family of proteins. In this time the family has expanded from a small number of members to the current situation where almost 50 chemokines have been identified. In the intervening years much progress has been made in characterizing the structure of chemokines, identifying their receptors and the unraveling the complex biologies in which they participate. As a result of these studies it is now clear that chemokines and their receptors are pivotal players in the orchestration of 'immune' tissue organogenesis as well as of the innate and adaptive immune responses. Thus chemokine biology now underpins a broad range of biological specialties. Importantly, 'translational' studies have provided incontrovertible evidence of the importance of chemokines and their receptors in a range of prominent pathologies. Thus essentially all immune and inflammatory pathologies have, at their heart, a dysfunction of some sort in either chemokine or chemokine receptor expression or responses. In addition, 2 chemokine receptors (CCR5 and CXCR4) have been shown to play profound roles in HIV pathogenesis through their ability to act as co-receptors for viral entry. Finally, details of the roles for chemokines and their receptors in cancer and cancer metastasis have provided important insights into the orchestration of the complex processes of tumorigenesis. Importantly, these pathology-focused studies have highlighted chemokines and their receptors as prominent therapeutic targets and over 10 years of work in this area is now being reflected in a number of chemokine receptor blockers being approved for clinical use. At the 'Chemotactic Cytokines' Gordon Conference will therefore explore the complex and diverse biologies of chemokines and their receptors and will integrate this with an up-to-date understanding of the regulation of these molecules. In addition we will examine recent therapeutic developments and will provide updates on the clinical progress of chemokine- based therapeutics. We hope that this will be a forward looking conference with opportunities for in depth analysis of where our field will be heading in the future. Importantly, this is likely to be the only international Chemokine-focused conference between 2008 and 2012 and is thus of fundamental importance to the field. The movement of blood cells throughout the body is key to our ability to fight infection and to repair wounded tissues and this movement is controlled by specialized molecules called chemokines. In addition chemokines are now known to be important for the development of many diseases such as autoimmune diseases, HIV infection and cancer. The funding requested in this application will be used in part-support of an international meeting at which the international leaders in the chemokine research field will come together to share their data and experiences.