2010 Chemotactic Cytokines Gordon Research Conference

描述（由申请人提供）：自将趋化因子定义为功能和生物化学上不同的蛋白质家族以来已有20年。在这段时间里，该家族已经从少数成员扩大到目前的情况，已经确定了近50种趋化因子。在这期间的几年里，在表征趋化因子的结构、鉴定其受体以及揭示其参与的复杂生物学方面取得了很大进展。作为这些研究的结果，现在清楚的是，趋化因子及其受体在“免疫”组织器官发生以及先天性和适应性免疫应答的协调中是关键的参与者。因此，趋化因子生物学现在支持广泛的生物学专业。重要的是，“翻译”研究提供了无可争议的证据，证明趋化因子及其受体在一系列突出的病理学中的重要性。因此，基本上所有的免疫和炎性病理在其核心都具有某种趋化因子或趋化因子受体表达或应答的功能障碍。此外，2种趋化因子受体（CCR5和CXCR4）已被证明通过其作为病毒进入的共受体的能力在HIV发病机制中发挥重要作用。最后，趋化因子及其受体在癌症和癌症转移中的作用的细节为肿瘤发生的复杂过程的编排提供了重要的见解。重要的是，这些以病理学为重点的研究突出了趋化因子及其受体作为突出的治疗靶点，并且在该领域超过10年的工作现在反映在许多被批准用于临床使用的趋化因子受体阻滞剂中。因此，在“趋化性细胞因子”戈登会议上，将探索趋化因子及其受体的复杂多样的生物学，并将其与对这些分子调控的最新理解相结合。此外，我们将研究最近的治疗进展，并将提供最新的临床进展，趋化因子为基础的治疗。我们希望这将是一个前瞻性的会议，有机会深入分析我们的领域将在未来的发展方向。重要的是，这可能是2008年至2012年期间唯一一次以趋化因子为重点的国际会议，因此对该领域具有根本的重要性。血细胞在全身的运动是我们抵抗感染和修复受伤组织的关键，这种运动是由称为趋化因子的专门分子控制的。此外，现在已知趋化因子对于许多疾病如自身免疫性疾病、HIV感染和癌症的发展是重要的。本申请中要求的资金将用于部分支持国际会议，在该会议上，趋化因子研究领域的国际领导人将聚集在一起分享他们的数据和经验。

DESCRIPTION (provided by applicant): It is 20 years since the definition of chemokines as a functionally and biochemically distinct family of proteins. In this time the family has expanded from a small number of members to the current situation where almost 50 chemokines have been identified. In the intervening years much progress has been made in characterizing the structure of chemokines, identifying their receptors and the unraveling the complex biologies in which they participate. As a result of these studies it is now clear that chemokines and their receptors are pivotal players in the orchestration of 'immune' tissue organogenesis as well as of the innate and adaptive immune responses. Thus chemokine biology now underpins a broad range of biological specialties. Importantly, 'translational' studies have provided incontrovertible evidence of the importance of chemokines and their receptors in a range of prominent pathologies. Thus essentially all immune and inflammatory pathologies have, at their heart, a dysfunction of some sort in either chemokine or chemokine receptor expression or responses. In addition, 2 chemokine receptors (CCR5 and CXCR4) have been shown to play profound roles in HIV pathogenesis through their ability to act as co-receptors for viral entry. Finally, details of the roles for chemokines and their receptors in cancer and cancer metastasis have provided important insights into the orchestration of the complex processes of tumorigenesis. Importantly, these pathology-focused studies have highlighted chemokines and their receptors as prominent therapeutic targets and over 10 years of work in this area is now being reflected in a number of chemokine receptor blockers being approved for clinical use. At the 'Chemotactic Cytokines' Gordon Conference will therefore explore the complex and diverse biologies of chemokines and their receptors and will integrate this with an up-to-date understanding of the regulation of these molecules. In addition we will examine recent therapeutic developments and will provide updates on the clinical progress of chemokine- based therapeutics. We hope that this will be a forward looking conference with opportunities for in depth analysis of where our field will be heading in the future. Importantly, this is likely to be the only international Chemokine-focused conference between 2008 and 2012 and is thus of fundamental importance to the field. The movement of blood cells throughout the body is key to our ability to fight infection and to repair wounded tissues and this movement is controlled by specialized molecules called chemokines. In addition chemokines are now known to be important for the development of many diseases such as autoimmune diseases, HIV infection and cancer. The funding requested in this application will be used in part-support of an international meeting at which the international leaders in the chemokine research field will come together to share their data and experiences.