Mechanisms associated with flares and remission in colitis
Mechanisms associated with flares and remission in colitis
批准号:
10623214
负责人:
SERGIO A. LIRA
金额:
$73.42万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-05-01 至 2026-05-31
关键词:
AffectAnimalsAntigensAutoimmune DiseasesBacteriaBeveragesBindingBiologyCD4 Positive T LymphocytesCandyCecumCellsChemicalsCherry - dietaryChildCitrobacter rodentiumClinicalColitisColonConsumptionCosmeticsCoupledDairyingDataDendritic CellsDeveloping CountriesDevelopmentDietDiet HabitsDiseaseDisease remissionEnvironmental Risk FactorEtiologyExposure toFlareFoodFood Coloring AgentsGenerationsGenesGeneticGenetic studyHaptensHormonesHumanHydration statusImmuneImmune responseImmune systemIn VitroIncidenceIncubatedIndividualInfectionInflammatoryInflammatory Bowel DiseasesInjectionsIntestinesLifeLinkMedicineModern MedicineMusMyeloid CellsNaphtholsPharmaceutical PreparationsPreventionProductionPropertyProteinsRegulatory T-LymphocyteResearch Project GrantsRoleSignal PathwayT-LymphocyteTestingTissuesWild Type MouseWorkcytokinedietaryexperimental studygut inflammationinterestinterleukin-23microbiotaresponsesoft drink
中文摘要
总结
英文摘要
Summary
Inflammatory bowel diseases (IBD) affect millions of individuals worldwide and its incidence is increasing. Both
genetic and environmental factors appear to play a role in IBD development. Genetic studies in humans have
linked the interleukin-23 (IL-23) signaling pathway with IBD, but the environmental factors contributing to disease,
have remained elusive. The rising incidence of worldwide IBD has been associated with westernization of dietary
habits in developing countries, however there is little scientific evidence to support causality. In this application
we will examine the role of a particular group of dietary additives, namely food colorants, to development of
colitis. We have now discovered that the food colorant Red 40, also known as Allura Red AC, promotes colitis
in mice that conditionally express low levels of IL-23 (referred to as R23FR mice), but not in wild type mice. Red
40 is the most abundant food colorant in the world, with annual production exceeding 2.3 million kg. It is widely
used in as red colorant in soft drinks, cherry flavored products, candy, dairy, drugs, and cosmetics. Of interest,
the Red 40-containing beverages, Kool-Aid and the hydrating solution Pedialyte Cherry can also cause colitis in
R23FR mice. Red 40-induced colitis in R23FR mice requires the microbiota and CD4+ T cells. Based on these
and other results presented here, we formulate a central hypothesis that the Red 40 or its metabolites haptenize
bacterial or endogenous proteins to generate tolerance in wild type mice, or colitis in mice in which IL-23
expression is dysregulated. We will study in this proposal the mechanisms involved in generation and prevention
of these responses. Specifically, we will define: 1) if Red 40 and its metabolite ANSA are haptens; 2) how Red
40 induces tolerance in control mice; and 3) if Red 40 or ANSA-specific T cells are generated in R23FR mice
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DOI:
10.1111/imm.13337
发表时间:
2021-08
期刊:
Immunology
影响因子:
6.4
作者:
[Whiteside SK, Grant FM, Gyori DS, Conti AG, Imianowski CJ, Kuo P, Nasrallah R, Sadiyah F, Lira SA, Tacke F, Eil RL, Burton OT, Dooley J, Liston A, Okkenhaug K, Yang J, Roychoudhuri R]
通讯作者:
Roychoudhuri R
Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of Epidermal Growth Factor Receptor-Dependent Serrated Polyps in Mouse Cecum.
白细胞介素 1 β 和基质金属肽酶 3 有助于小鼠盲肠中表皮生长因子受体依赖性锯齿状息肉的形成。
DOI:
10.1053/j.gastro.2019.08.025
发表时间:
2019
期刊:
Gastroenterology
影响因子:
29.4
作者:
[He,Zhengxiang, Chen,Lili, Chen,Grace, Smaldini,Paola, Bongers,Gerold, Catalan-Dibene,Jovani, Furtado,GlauciaC, Lira,SergioA]
通讯作者:
Lira,SergioA
DOI:
10.1016/j.cyto.2018.08.009
发表时间:
2018-11
期刊:
Cytokine
影响因子:
3.8
作者:
[He Z, Chen L, Furtado GC, Lira SA]
通讯作者:
Lira SA
DOI:
10.1016/j.cmet.2021.04.015
发表时间:
2021-07-06
期刊:
Cell metabolism
影响因子:
29
作者:
[He Z, Chen L, Catalan-Dibene J, Bongers G, Faith JJ, Suebsuwong C, DeVita RJ, Shen Z, Fox JG, Lafaille JJ, Furtado GC, Lira SA]
通讯作者:
Lira SA
DOI:
10.1038/mi.2015.102
发表时间:
2016-05
期刊:
Mucosal immunology
影响因子:
8
作者:
[]
通讯作者:
Mechanisms associated with diet-induced colitis
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批准号:9886336
-
项目类别:
-
资助金额:$58.89万
-
财政年份:2020
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with diet-induced colitis
-
批准号:10093034
-
项目类别:
-
资助金额:$58.89万
-
财政年份:2020
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with diet-induced colitis
-
批准号:10553265
-
项目类别:
-
资助金额:$58.89万
-
财政年份:2020
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with diet-induced colitis
-
批准号:10339359
-
项目类别:
-
资助金额:$58.89万
-
财政年份:2020
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with flares and remission in colitis
-
批准号:9922284
-
项目类别:
-
资助金额:$38.14万
-
财政年份:2017
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with flares and remission in colitis
-
批准号:10438874
-
项目类别:
-
资助金额:$70.11万
-
财政年份:2017
-
负责人:SERGIO A. LIRA
-
依托单位:
Mechanisms associated with flares and remission in colitis
-
批准号:10297538
-
项目类别:
-
资助金额:$71.94万
-
财政年份:2017
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:8519092
-
项目类别:
-
资助金额:$33.06万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:8706828
-
项目类别:
-
资助金额:$34.12万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:8319298
-
项目类别:
-
资助金额:$35.17万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:8883405
-
项目类别:
-
资助金额:$35.17万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:9982797
-
项目类别:
-
资助金额:$40.26万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:8160339
-
项目类别:
-
资助金额:$35.17万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:9104512
-
项目类别:
-
资助金额:$40.26万
-
财政年份:2011
-
负责人:SERGIO A. LIRA
-
依托单位:
Molecular pathogenesis of intestinal serrated polyps
-
批准号:9336799
-
项目类别:
-
资助金额:$40.26万
-
财政年份:2011
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负责人:SERGIO A. LIRA
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依托单位:
2010 Chemotactic Cytokines Gordon Research Conference
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批准号:7896906
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项目类别:
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资助金额:$0.3万
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财政年份:2010
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负责人:SERGIO A. LIRA
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依托单位:
The role of chemokines in experimental thyroiditis
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批准号:7998757
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项目类别:
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资助金额:$0.77万
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财政年份:2010
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负责人:SERGIO A. LIRA
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依托单位:
Epithelial TLR signaling and IgA production
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批准号:7700340
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项目类别:
-
资助金额:$25.43万
-
财政年份:2009
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负责人:SERGIO A. LIRA
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依托单位:
Epithelial TLR signaling and IgA production
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批准号:7866496
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项目类别:
-
资助金额:$20.98万
-
财政年份:2009
-
负责人:SERGIO A. LIRA
-
依托单位:
2008 Chemotactic Cytokines Gordon Research Conference
-
批准号:7539465
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项目类别:
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资助金额:$0.3万
-
财政年份:2008
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负责人:SERGIO A. LIRA
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依托单位:
海外基金