NMDA RECEPTOR AS THERAPEUTIC TARGET FOR PARKINSON?S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是获得体内证据表明，在帕金森病的动物模型，6-OH-多巴胺损伤的大鼠中，阻断含NR 2D的NMDA受体对帕金森病运动症状具有有益作用。这个项目的工作最近刚刚开始。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to obtain in vivo proof that blockade of NR2D-containing NMDA receptors has beneficial actions on parkinsonian motor symptoms in an animal model of Parkinson's disease, the 6-OH-dopamine-lesioned rat. Work on this project just recently started.