SPECIES-SPECIFICITY OF HIV-1 AND SIV IN OVERCOMING RESTRICTION BY TETHERIN/BST2

HIV-1 和 SIV 克服 Tetherin/BST2 限制的物种特异性

• 批准号: 7958383
• 负责人: David T Evans
• 金额: $ 20.61万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958383
• 关键词: Accounting; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HIV-1; Human; Institution; Macaca mulatta; New England; Primates; Proteins; Research; Research Personnel; Resources; SIV; Source; Species Specificity; United States National Institutes of Health; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study identified the gene product of SIV that opposes tetherin in rhesus macaques and defined the differences between human and rhesus tetherin that account for species-specific restriction of HIV-1 and SIV.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究鉴定了恒河猴中对抗 tetherin 的 SIV 基因产物，并明确了人类和恒河猴 tetherin 之间的差异，这些差异解释了 HIV-1 和 SIV 的物种特异性限制。