MATERNAL-FETAL TRANSPORT OF NEUROTOXINS USING PET IMAGING

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：使用 PET 成像评估假定神经毒素的母体-胎儿体内转运。 在一项涉及 WNPRC 繁殖群的怀孕恒河猴的初步研究中，我们使用 PET-CT 成像来研究母胎物质传输。本研究的目的是评估多巴胺受体示踪剂从母亲到胎儿的体内转运。观察到快速转运，并观察到示踪剂在富含多巴胺受体的胎儿纹状体中的特异性摄取和保留。这项研究证明了这种非侵入性技术的可行性。在等待向美国国立卫生研究院提交的拨款提案的资助之前，计划的未来工作将评估胎儿对环境神经毒素的吸收，以便对子宫内神经毒素暴露进行基于科学的风险评估。这项研究使用了动物服务。 NIH 的申请正在等待中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To assess in vivo maternal-fetal transport of putative neurotoxins using PET imaging. We used PET-CT imaging to study maternal-fetal transport of materials in one preliminary study involving a pregnant rhesus macaque of the WNPRC breeding colony. The goal of this study was to assess the in vivo transport from the mother to the fetus of a dopamine receptor tracer. Rapid transport was observed and specific uptake and retention of the tracer in the fetal striatum, which is rich with dopamine receptors, was seen. This study demonstrates the feasibility of this non-invasive technique. Future work planned, pending the funding of a grant proposal submitted to the NIH, will assess fetal uptake of environmental neurotoxins in order to make science-based risk assessment of neurotoxin exposure in utero. This research used Animal Services. An NIH application is pending.