MATERNAL-FETAL TRANSPORT OF NEUROTOXINS USING PET IMAGING

使用 PET 成像进行神经毒素的母体-胎儿转运

• 批准号: 7716461
• 负责人: Onofre DeJesus
• 金额: $ 4.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-23 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716461
• 关键词: Animals; Applications Grants; Breeding; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Dopamine Receptor; Fetus; Funding; Future; Goals; Grant; Image; Institution; Invasive; Macaca mulatta; Mothers; Neurotoxins; Patient currently pregnant; Perinatal Exposure; Positron-Emission Tomography; Research; Research Personnel; Resources; Risk Assessment; Science; Services; Source; Techniques; Tracer; United States National Institutes of Health; Work; base; fetal; in vivo; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To assess in vivo maternal-fetal transport of putative neurotoxins using PET imaging. We used PET-CT imaging to study maternal-fetal transport of materials in one preliminary study involving a pregnant rhesus macaque of the WNPRC breeding colony. The goal of this study was to assess the in vivo transport from the mother to the fetus of a dopamine receptor tracer. We observed rapid transport and specific uptake and retention of the tracer in the fetal striatum, which is rich with dopamine receptors. This study demonstrates the feasibility of this non-invasive technique. We plan future work pending the funding of a grant proposal submitted to the NIH. We aim to assess fetal uptake of environmental neurotoxins in order to make science-based risk assessment of neurotoxin exposure in utero. This research used Animal Services.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用PET成像评估推定神经毒素的体内母胎转运。 我们在一项涉及WNPRC繁殖群怀孕恒河猴的初步研究中使用PET-CT成像来研究材料的母胎运输。本研究的目的是评估多巴胺受体示踪剂从母体到胎儿的体内转运。我们观察到快速运输和特定的摄取和保留的示踪剂在胎儿纹状体，这是丰富的多巴胺受体。这项研究证明了这种非侵入性技术的可行性。我们计划未来的工作，等待提交给美国国立卫生研究院的拨款建议的资金。我们的目的是评估胎儿摄取的环境神经毒素，以使科学为基础的风险评估神经毒素暴露在子宫内。这项研究使用动物服务。