BARTONELLA MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是利用SIV/猕猴模型系统来确定SIV感染、免疫低下的猕猴中巴尔通体感染的发病机制，并评价SIV/猕猴系统作为BA的潜在模型。感染SIV的动物，在免疫缺陷的不同阶段，将被皮内接种亨氏杆菌、杆状杆菌或昆塔纳杆菌，并监测菌血症的发病、持续时间、免疫反应和临床结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to utilize the SIV/macaque model system to determine the pathogenesis of Bartonella infection in SIV-infected, immunocompromised macaques, and evaluate the SIV/macaque system as a potential model for BA. SIV-infected animals, at various stages of immunodeficiency, will be inoculated intradermally with B. henselae, B. bacilliformis, or B. quintana organisms, and monitored for onset, duration, immune response, and clinical outcome of bacteremia.