BARTONELLA MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN

艾滋病机会性病原体的巴尔通体模型

• 批准号: 7715578
• 负责人: JANE E KOEHLER
• 金额: $ 16.9万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715578
• 关键词: Animals; Bacteremia; Bartonella; Bartonella Infections; Biological Models; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Immune response; Immunocompromised Host; Immunologic Deficiency Syndromes; Institution; Macaca; Modeling; Monitor; Organism; Outcome; Pathogenesis; Research; Research Personnel; Resources; Source; Staging; System; United States National Institutes of Health; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Utilize the SIV/macaque model system to determine the pathogenesis of Bartonella infection in SIV-infected, immunocompromised macaques, and evaluate the SIV/macaque system as a potential model for BA. SIV-infected animals, at various stages of immunodeficiency, will be inoculated intradermally with B. henselae, B. bacilliformis, or B. quintana organisms, and monitored for onset, duration, immune response, and clinical outcome of bacteremia.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：利用SIV/猕猴模型系统研究SIV感染、免疫低下的猕猴巴尔通体感染的发病机制，并评价SIV/猕猴系统作为BA的潜在模型。感染SIV的动物，在免疫缺陷的不同阶段，将被皮内接种亨氏杆菌、杆状杆菌或昆塔纳杆菌，并监测菌血症的发病、持续时间、免疫反应和临床结果。