CELLULAR HOMOLOGS IN A NEW SIMIAN HERPESVIRUS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 艾滋病相关的卡波西肉瘤（KS）是主要的艾滋病相关的恶性肿瘤。 据信，逆转录病毒HIV和疱疹病毒卡波西肉瘤相关疱疹病毒（KSHV）之间的相互作用导致疾病发病。 KSHV感染和KSHV相关的恶性肿瘤是新出现的疾病，在地中海和撒哈拉以南非洲流行，但正在蔓延到美国和欧洲。 据信，与KSHV样疱疹病毒（RV1 rhadinovirus，RFHVMn）相关的SRV-2相关的腹膜后纤维瘤病（RF）是理解逆转录病毒和疱疹病毒在诱导肿瘤发生中的相互作用的独特动物模型。 了解这种动物模型中的病毒传播和肿瘤发生将提供有关人类和猕猴疾病的独特信息，这是开发KS治疗方法的必要先决条件。 在这个项目中，我们建议建立猕猴RFHV和密切相关的猕猴RV2鼻状病毒的感染周期的基线参数。 为了确定这些病毒是否在腹膜后纤维瘤病（RF）的发展中发挥作用，我们将描述它们的感染周期以及SRV-2和其他免疫抑制剂对这些周期的干扰。 我们将研究病毒的传播和宿主对感染的反应。 研究人群将包括RFHV或RV2鼻状病毒活动性、潜伏性或实验性感染的猕猴。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS-related Kaposi's sarcoma (KS) is the major AIDS-related malignancy. It is believed that an interaction between the retrovirus, HIV, and the herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), results in disease pathogenesis. KSHV-infection and KSHV-related malignancies are newly emerging diseases which are prevalent in the Mediterranean and Sub-Saharan Africa but are spreading into the U.S. and Europe. It is believed that SRV-2 related retroperitoneal fibromatosis (RF) which is associated with the KSHV-like herpesvirus, RV1 rhadinovirus, RFHVMn, is a unique animal model for understanding the interactions of retroviruses and herpesviruses in the induction of tumorigenesis. Understanding virus transmission and tumor initiation in this animal model would provide unique information concerning both the human and macaque diseases which is an essential prerequisite to developing treatments for KS. In this project, we propose to establish the baseline parameters of the infectious cycle of the macaque RFHV and the closely related macaque RV2 rhadinoviruses. To determine if these viruses play a role in the development of retroperitoneal fibromatosis (RF) we will characterize their infectious cycles and the perturbation of these cycles by SRV-2 and other immunosuppressive agents. We will study virus transmission and the host response to infection. Study populations will include macaques with either active, latent or experimental infections with RFHV or RV2 rhadinovirus.