CELLULAR HOMOLOGS IN A NEW SIMIAN HERPESVIRUS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。艾滋病相关卡波西肉瘤（KS）是主要的艾滋病相关恶性肿瘤。人们认为逆转录病毒HIV和疱疹病毒卡波西氏肉瘤相关疱疹病毒（KSHV）之间的相互作用导致了疾病的发病机制。kshv感染和与kshv相关的恶性肿瘤是新出现的疾病，在地中海和撒哈拉以南非洲流行，但正在蔓延到美国和欧洲。我们认为SRV-2相关的腹膜后纤维瘤病（RF）与kshv样疱疹病毒（RFHVMn）相关，是了解逆转录病毒和疱疹病毒在诱导肿瘤发生中的相互作用的独特动物模型。了解病毒在该动物模型中的传播和肿瘤发生，将为人类和猕猴疾病提供独特的信息，这是开发KS治疗方法的必要前提。本项目拟建立猕猴RFHV感染周期的基线参数。为了确定该病毒是否在腹膜后纤维瘤病（RF）的发展中起作用，我们将描述其感染周期以及SRV-2和其他免疫抑制剂对这些周期的扰动。我们将研究病毒传播和宿主对感染的反应。研究人群将包括活跃、潜伏或实验性感染RFHV的猕猴。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. AIDS-related Kaposi's sarcoma (KS) is the major AIDS-related malignancy. It is believed that an interaction between the retrovirus, HIV, and the herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), results in disease pathogenesis. KSHV-infection and KSHV-related malignancies are newly emerging diseases which are prevalent in the Mediterranean and Sub-Saharan Africa but are spreading into the U.S. and Europe. It is believed that SRV-2 related retroperitoneal fibromatosis (RF) which is associated with the KSHV-like herpesvirus, RFHVMn, is a unique animal model for understanding the interactions of retroviruses and herpesviruses in the induction of tumorigenesis. Understanding virus transmission and tumor initiation in this animal model would provide unique information concerning both the human and macaque diseases which is an essential prerequisite to developing treatments for KS. In this project, we propose to establish the baseline parameters of the infectious cycle of the macaque RFHV. To determine if this virus plays a role in the development of retroperitoneal fibromatosis (RF) we will characterize its infectious cycles and the perturbation of these cycles by SRV-2 and other immunosuppressive agents. We will study virus transmission and the host response to infection. Study populations will include macaques with either active, latent or experimental infections with RFHV.