Ontology-based Information Network to Support Vaccine Research

基于本体的信息网络支持疫苗研究

• 批准号: 8120230
• 负责人: Yongqun He
• 金额: $ 26.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8120230
• 关键词: Algorithms; Attenuated Live Virus Vaccine; Automated Annotation; Bacterial Genes; Brucella; Brucella Vaccine; Clinical Trials; Collaborations; Communicable Diseases; Communities; Consensus; Controlled Vocabulary; Data; Databases; Development; Dictionary; Ensure; Escherichia coli; Escherichia coli Vaccines; Foundations; Genome; Genomics; Goals; Immune; Immune response; Immune system; Immunity; Informatics; Information Networks; Information Retrieval; Journals; Laboratories; Literature; MeSH Thesaurus; Methodology; Methods; Modeling; National Center for Integrative Biomedical Informatics; Natural Language Processing; Online Systems; Ontology; Organism; Paper; Preparation; Process; Proteins; Publications; Publishing; Research; Research Personnel; Retrieval; Scientist; Semantics; Smallpox Vaccine; Staging; Standardization; Structure; Subunit Vaccines; System; Testing; Training; Vaccine Research; Vaccines; base; biomedical ontology; computer based Semantic Analysis; data integration; editorial; gene function; genome-wide; interest; journal article; knowledge base; microorganism; novel; novel vaccines; pathogen; programs; repository; research study; statistics; text searching; user-friendly; vaccine candidate; vaccine development; vaccine evaluation; web interface

DESCRIPTION (provided by applicant): Since the introduction of Edward Jenner's smallpox vaccine in 1796, vaccines have proven invaluable for their ability to stimulate the immune system and to confer protection against pathogenic organisms. Progress in modern vaccine research has been accompanied by a dramatic increase in the number of vaccine-related papers in the published literature. It has become increasingly challenging to identify and annotate vaccine data from this large and diverse literature which no one scientist or team can fully master. Although vaccine databases exist that emphasize commercialized vaccines, no public central repository is available to store research data concerning commercial vaccines, vaccines in clinical trials, or vaccine candidates in early stages of development, in a fashion that render such data available for advanced analyses. To fill this need, we have developed VIOLIN (http://www.violinet.org), a web-based database system for annotation, storage, and analysis of published vaccine data. An ontology represents consensus-based controlled vocabularies of terms and relations, with associated definitions which are logically formulated in such a way as to promote automated reasoning. A bottleneck of vaccine research and further VIOLIN development is the lack of a vaccine ontology, which in turn makes a significant obstacle for vaccine data standardization, retrieval, integration, and advanced analysis and prediction. Our goal is to develop the community-based Vaccine Ontology (VO) and apply it to efficient vaccine literature mining and analysis of protective immune mechanisms. We will focus on two model pathogens: Escherichia coli and Brucella species. This project contains three specific aims: (1) develop a community-based Vaccine Ontology (VO), and apply it to establish a vaccine knowledgebase and to promote vaccine data integration and query through Semantic Web. The VO development will be achieved through collaboration with vaccine researchers, the Infectious Disease Ontology (IDO) Initiative, and the National Center for Biomedical Ontology (NCBO); (2) develop a VO-based natural language processing (NLP) system and apply it for more efficient retrieval of Brucella and E. coli vaccine information, automated annotation of journal articles with VO terms, and VO improvement. This task will be achieved by collaboration with the National Center for Integrative Biomedical Informatics (NCIBI). (3) analyze and predict vaccine targets and protective immune networks attributable to the interactions between host and vaccine. This will be achieved mainly by VO-based literature mining and a novel genome- and literature-based statistical methodology. This project will be implemented by a strong collaborative team and supported from a large user community. The Vaccine Ontology and its applications to literature mining and for studying protective immunity against Brucella spp. and E. coli will lay a strong foundation for further advanced informatics research on vaccines against infectious diseases in the post-genomics and information era.

描述（由申请人提供）：自1796年爱德华·詹纳（Edward Jenner）的天花疫苗问世以来，疫苗已被证明具有刺激免疫系统和保护人体免受病原微生物侵害的能力。在现代疫苗研究取得进展的同时，已发表的文献中与疫苗有关的论文数量急剧增加。从这些庞大而多样的文献中识别和注释疫苗数据变得越来越具有挑战性，因为没有一个科学家或团队能够完全掌握这些数据。虽然存在强调商业化疫苗的疫苗数据库，但没有公共的中央储存库来储存有关商业化疫苗、临床试验疫苗或早期开发阶段候选疫苗的研究数据，从而使这些数据可用于高级分析。为了满足这一需求，我们开发了小提琴（http://www.violinet.org），这是一个基于web的数据库系统，用于注释、存储和分析已发布的疫苗数据。本体表示基于共识的术语和关系的受控词汇表，以及以促进自动推理的方式逻辑表述的相关定义。疫苗本体的缺乏是疫苗研究和进一步发展的瓶颈，这反过来又对疫苗数据的标准化、检索、集成以及高级分析和预测造成了重大障碍。我们的目标是开发基于社区的疫苗本体（VO），并将其应用于有效的疫苗文献挖掘和保护性免疫机制分析。我们将重点关注两种模式病原体：大肠杆菌和布鲁氏菌。本项目有三个具体目标：(1)开发基于社区的疫苗本体（Vaccine Ontology， VO），并应用其建立疫苗知识库，通过语义Web促进疫苗数据的整合和查询。VO的开发将通过与疫苗研究人员、传染病本体（IDO）倡议和国家生物医学本体中心（NCBO）的合作来实现；(2)开发基于VO的自然语言处理（NLP）系统，并将其应用于布鲁氏菌和大肠杆菌疫苗信息的更高效检索、带有VO术语的期刊文章的自动注释以及VO改进。这项任务将与国家综合生物医学信息学中心（NCIBI）合作完成。(3)分析和预测宿主与疫苗相互作用产生的疫苗靶点和保护性免疫网络。这将主要通过基于vo的文献挖掘和一种新的基于基因组和文献的统计方法来实现。该项目将由一个强大的协作团队实施，并得到大型用户社区的支持。疫苗本体及其在布鲁氏杆菌和大肠杆菌的保护性免疫研究和文献挖掘中的应用，将为后基因组学和信息时代进一步深入开展传染病疫苗信息学研究奠定坚实的基础。