STRUCTURAL STUDY OF FCRY, AN AVIAN IGY TRANSCYTOSIS RECEPTOR
禽类IGY转细胞受体FCRY的结构研究
基本信息
- 批准号:8362373
- 负责人:
- 金额:$ 0.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-03-01 至 2012-02-29
- 项目状态:已结题
- 来源:
- 关键词:BindingBirdsBloodFamilyFundingGrantIgYImmunoglobulin GMammalsMembraneMothersNational Center for Research ResourcesNeonatalPhospholipase A2Principal InvestigatorRadiationResearchResearch InfrastructureResourcesSmall IntestinesSourceUnited States National Institutes of HealthYolk Sacacquired immunitycosthuman diseaseimprovedneonatal Fc receptorreceptorstructural biologytranscytosis
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
For mammals, acquired immunity is achieved by transferring IgG from mother to young through a receptor called FcRn, which binds IgG at acidic pH in the neonatal small intestine and releases it at basic pH into blood. FcRY is an avian functional equivalent of FcRn, but belongs to a different structural family which includes phospholipase A2 receptor. FcRY binds IgY, the avian counterpart of IgG, and transfers it across yolk sac membranes. It has been shown that the ectodomain of FcRY has a large conformational change between acidic and basic pH which corresponds to the binding and the releasing of IgY. However, the structural details of this conformational change are unclear. Here we propose to use SAXS to investigate the conformational change of FcRY and its binding with IgY. This could improve our current understanding of the mechanisms of acquired immunity and also the strategies against avian- associated human diseases.
这个子项目是许多利用资源的研究子项目之一
由NIH/NCRR资助的中心拨款提供。子项目的主要支持
而子项目的主要调查员可能是由其他来源提供的,
包括其它NIH来源。 列出的子项目总成本可能
代表子项目使用的中心基础设施的估计数量,
而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。
对于哺乳动物,获得性免疫是通过将IgG从母亲通过称为FcRn的受体转移到年轻人来实现的,该受体在新生儿小肠中的酸性pH下结合IgG并在碱性pH下将其释放到血液中。FcRY是FcRn的禽类功能等同物,但属于包括磷脂酶A2受体的不同结构家族。FcRY结合IgG的禽类对应物IgY,并将其转移穿过卵黄囊膜。已经表明,FcRY的胞外域在酸性和碱性pH之间具有大的构象变化,其对应于IgY的结合和释放。然而,这种构象变化的结构细节尚不清楚。在这里,我们建议使用SAXS来研究FcRY的构象变化及其与IgY的结合。这可以提高我们目前对获得性免疫机制的理解,也可以提高我们对禽类相关疾病的防治策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Yongqun He其他文献
Yongqun He的其他文献
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{{ truncateString('Yongqun He', 18)}}的其他基金
VIOLIN 2.0: Vaccine Information and Ontology LInked kNowledgebase
VIOLIN 2.0:疫苗信息和本体链接知识库
- 批准号:
10687095 - 财政年份:2022
- 资助金额:
$ 0.08万 - 项目类别:
VIOLIN 2.0: Vaccine Information and Ontology LInked kNowledgebase
VIOLIN 2.0:疫苗信息和本体链接知识库
- 批准号:
10506013 - 财政年份:2022
- 资助金额:
$ 0.08万 - 项目类别:
Ontology-supported Integrative Analysis and Visualization of Vaccine-induced Pathways and Networks
本体支持的疫苗诱导途径和网络的综合分析和可视化
- 批准号:
9810625 - 财政年份:2019
- 资助金额:
$ 0.08万 - 项目类别:
Ontology-based Information Network to Support Vaccine Research
基于本体的信息网络支持疫苗研究
- 批准号:
8311060 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
Ontology-based Information Network to Support Vaccine Research
基于本体的信息网络支持疫苗研究
- 批准号:
7935464 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
Ontology-based Information Network to Support Vaccine Research
基于本体的信息网络支持疫苗研究
- 批准号:
7735790 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
Development and Evaluation of a Dual-Antigen Nasal Brucella Vaccine
双抗原鼻布鲁氏菌疫苗的开发与评价
- 批准号:
7531644 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
Ontology-based Information Network to Support Vaccine Research
基于本体的信息网络支持疫苗研究
- 批准号:
8120230 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
Development and Evaluation of a Dual-Antigen Nasal Brucella Vaccine
双抗原鼻布鲁氏菌疫苗的开发与评价
- 批准号:
7896765 - 财政年份:2009
- 资助金额:
$ 0.08万 - 项目类别:
GENE EXPRESSION IN BRUCELLA-INFECTED MACROPHAGES
布鲁氏菌感染的巨噬细胞中的基因表达
- 批准号:
7193233 - 财政年份:2004
- 资助金额:
$ 0.08万 - 项目类别:
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