Deciphering the function of Mce proteins from Mycobacterium tuberculosis

描述(申请人提供)：结核病(TB)仍然是世界范围内的一个主要健康问题。结核分枝杆菌是人类结核病的病原体，它使用蛋白质和其他被称为“毒力因子”的化合物来破坏人类的宿主防御系统，并在感染期间破坏和入侵人类宿主细胞。这个项目的主要目标是研究结核分枝杆菌在宿主感染中成功感染所必需的蛋白质家族。因此，这项研究可以深入了解结核分枝杆菌在人类感染过程中所涉及的机制。更好地了解这一过程将有助于制定控制这种疾病的新战略，包括设计有效的疫苗。公共卫生相关性：结核病(TB)仍然是世界范围内的一个主要健康问题。结核分枝杆菌是人类结核病的病原体，它使用蛋白质和其他被称为“毒力因子”的化合物来破坏人类的宿主防御系统，并在感染期间破坏和入侵人类宿主细胞。这个项目的主要目标是研究结核分枝杆菌在宿主感染中成功感染所必需的蛋白质家族。因此，这项研究可以深入了解结核分枝杆菌在人类感染过程中所涉及的机制。更好地了解这一过程将有助于制定控制这种疾病的新战略，包括设计有效的疫苗。

DESCRIPTION (provided by applicant): Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine. PUBLIC HEALTH RELEVANCE: Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.