Deciphering the function of Mce proteins from Mycobacterium tuberculosis

解读结核分枝杆菌 Mce 蛋白的功能

• 批准号: 8308963
• 负责人: Fabiana Bigi
• 金额: $ 7.57万
• 依托单位: NATIONAL INSTITUTE OF AGRICULTURE TECH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308963
• 关键词: ATP-binding cassette transport; Actinomycetales; Bacteria; Biological Process; Carbon; Cells; Cholesterol; Collection; Complex; Data; Development; Faculty; Gene Expression; Genes; Genome; Genus Mycobacterium; Goals; Health; Host Defense; Human; Infection; Invaded; Investigation; Knowledge; Lipids; Membrane; Metabolism; Modeling; Mycobacterium smegmatis; Mycobacterium tuberculosis; Open Reading Frames; Operon; Organism; Physiological; Process; Protein Family; Proteins; RNA; Regulator Genes; Research; Role; Structural Genes; System; Technology; Training; Transmembrane Transport; Tuberculosis; Vaccines; Virulence; Virulence Factors; Work; base; design; disorder control; experience; insight; lipid metabolism; lipid transport; mouse model; mutant; mycobacterial; pathogenic bacteria; success; working group

DESCRIPTION (provided by applicant): Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine. PUBLIC HEALTH RELEVANCE: Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.

描述（由申请人提供）：结核病（TB）仍然是全球主要的健康问题。结核分枝杆菌是人类结核病的病原体，它使用蛋白质和其他称为“毒力因子”的化合物来破坏人类宿主的防御，并在感染过程中破坏和入侵人类宿主细胞。该项目的主要目标是研究M.结核病成功感染宿主。因此，本研究为深入了解M.人类的肺结核更好地了解这一过程将有助于制定控制这一疾病的新战略，包括设计有效的疫苗。公共卫生相关性：结核病（TB）仍然是世界范围内的主要健康问题。结核分枝杆菌是人类结核病的病原体，它使用蛋白质和其他称为“毒力因子”的化合物来破坏人类宿主的防御，并在感染过程中破坏和入侵人类宿主细胞。该项目的主要目标是研究M.结核病成功感染宿主。因此，本研究为深入了解M.人类的肺结核更好地了解这一过程将有助于制定控制这一疾病的新战略，包括设计有效的疫苗。

项目成果

Virulence factors of the Mycobacterium tuberculosis complex.

• DOI: 10.4161/viru.22329
• 发表时间: 2013-01-01
• 期刊: Virulence
• 影响因子: 5.2
• 作者: Forrellad MA;Klepp LI;Gioffré A;Sabio y García J;Morbidoni HR;de la Paz Santangelo M;Cataldi AA;Bigi F
• 通讯作者: Bigi F

Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis.

• DOI: 10.1016/j.tube.2013.12.005
• 发表时间: 2014-03
• 期刊: Tuberculosis (Edinburgh, Scotland)
• 作者: Forrellad MA;McNeil M;Santangelo Mde L;Blanco FC;García E;Klepp LI;Huff J;Niederweis M;Jackson M;Bigi F
• 通讯作者: Bigi F

Assessment of the immune responses induced in cattle after inoculation of a Mycobacterium bovis strain deleted in two mce2 genes.

• DOI: 10.1155/2012/258353
• 发表时间: 2012
• 期刊: Journal of biomedicine & biotechnology
• 作者: Blanco FC;Soria M;Gravisaco MJ;Bianco MV;Meikle V;Garbaccio S;Vagnoni L;Cataldi AA;Bigi F
• 通讯作者: Bigi F