Rod Cone Interactions in Mesopic Vision

中间视觉中的杆锥体相互作用

• 批准号: 8053768
• 负责人: Dingcai Cao
• 金额: $ 7.41万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8053768
• 关键词: Age related macular degeneration; Amacrine Cells; Area; Blindness; Cells; Color Visions; Complex; Diabetic Retinopathy; Disease Management; Early Diagnosis; Eye diseases; Gap Junctions; Goals; Human; Lead; Light; Lighting; Measurement; Measures; Mediating; Methodology; Methods; Monitor; Neural Pathways; Outcome; Pathway interactions; Physiological; Primates; Psychophysiology; Reporting; Research; Retina; Retinal; Retinal Cone; Retinal Ganglion Cells; Retinitis Pigmentosa; Role; Signal Transduction; Stimulus; Vertebrate Photoreceptors; Vision; Work; base; ganglion cell; improved; in vivo; neuromechanism; new technology; novel; public health relevance; relating to nervous system; research study; response; retinal rods

DESCRIPTION (provided by applicant): Mesopic vision, a combination of rod and cone vision in modest but not low lighting situations, is a fundamental but challenging research area. It is fundamental because the interactions between rod and cone signals alter several aspects of visual function, such as color vision and temporal vision. It is challenging because traditional methodology has failed to yield a clear understanding of its complex role in human vision. The proposed research will use a novel four-primary photostimulator that independently controls rod and cone excitations. The study will combine psychophysical and physiological methodologies to investigate the neural mechanisms that mediate mesopic vision. Psychophysical experiments will be conducted to assess rod-cone interactions in color vision and temporal vision at mesopic light levels. Physiological experiments will be conducted to measure rod and cone inputs to ganglion cells in primates under mesopic illuminations. The goal is to determine retinal pathways that contribute to mesopic vision. The outcome of this work can provide a framework for developing new methods for early detection and monitoring of retinal eye diseases that cause blindness, including age-related macular degeneration, diabetic retinopathy, rod-cone dystrophies and retinitis pigmentosa. PUBLIC HEALTH RELEVANCE: At mesopic light levels, both rod and cone photoreceptors are active. This proposed research will use a novel technology to independently control rod and cone stimulations to investigate how signals arising from rods and cones interact to alter vision. From this, we will better understand the neural mechanisms mediating rod-cone interactions in mesopic vision, which could lead to developing new technologies to improve disease management through early detection and monitoring of retinal eye diseases that lead to blindness, including age-related macular degeneration, diabetic retinopathy, rod-cone dystrophies and retinitis pigmentosa.

描述（由申请人提供）：中间视觉是在适度但不低的照明情况下杆状视觉和锥状视觉的组合，是一个基本但具有挑战性的研究领域。这是很重要的，因为视杆细胞和视锥细胞信号之间的相互作用会改变视觉功能的多个方面，例如色觉和时间视觉。这是具有挑战性的，因为传统方法无法清楚地理解其在人类视觉中的复杂作用。拟议的研究将使用一种新型的四基色光刺激器，可以独立控制视杆和视锥的激发。该研究将结合心理物理学和生理学方法来研究介导中间视觉的神经机制。将进行心理物理学实验，以评估中视光水平下色觉和时间视觉中视杆细胞与视锥细胞的相互作用。将进行生理实验来测量中间视觉照明下灵长类动物神经节细胞的视杆细胞和视锥细胞输入。目标是确定有助于中间视觉的视网膜通路。这项工作的成果可以为开发新方法提供一个框架，用于早期检测和监测导致失明的视网膜眼部疾病，包括年龄相关性黄斑变性、糖尿病性视网膜病变、视杆细胞营养不良和色素性视网膜炎。 公共健康相关性：在中间光水平下，视杆细胞和视锥细胞光感受器均处于活动状态。这项拟议的研究将使用一种新技术来独立控制视杆细胞和视锥细胞刺激，以研究视杆细胞和视锥细胞产生的信号如何相互作用以改变视力。由此，我们将更好地了解中间视觉中介导视杆细胞与视锥细胞相互作用的神经机制，这可能会导致开发新技术，通过早期检测和监测导致失明的视网膜眼部疾病（包括年龄相关性黄斑变性、糖尿病性视网膜病变、视杆细胞营养不良和色素性视网膜炎）来改善疾病管理。