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Multicenter AIDS Cohort Study

多中心艾滋病队列研究

基本信息

批准号：
8138167
负责人：
John P Phair
金额：
$ 598.5万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-20 至 2012-09-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8138167
关键词：
Accounting Acquired Immunodeficiency Syndrome Affect African American Aging American Arts Behavior Behavioral Biological Biological Markers Cardiovascular Diseases Chicago Clinic Clinical Cohort Studies Combined Modality Therapy Competence County Hospitals Data Development Diabetes Mellitus Disease Disease Progression Drug usage Environment Environmental Risk Factor Exposure to Funding Genetic Genotype Goals HIV HIV-1 Health Highly Active Antiretroviral Therapy Hispanics Illicit Drugs Immune Immune system Immunologics Incidence Infection Investigation Kidney Diseases Leadership Learning Lipodystrophy Liver diseases Long-Term Effects Maintenance Malignant Neoplasms Neoplasms Neurocognitive Organ Outcome Participant Pathogenesis Persons Recording of previous events Research Research Project Grants Resistance Risk Risk Factors Role Sampling Specimen Universities Virus Virus Diseases Woman age effect age group antiretroviral therapy clinical research site cohort cooking design high throughput technology men men who have sex with men new technology physical process prospective psychologic response sample collection transmission process virus pathogenesis

项目摘要

DESCRIPTION (provided by applicant): The Chicago component of the Multicenter AIDS Cohort Study (MACS) is composed of a representative sample of men infected with HIV or at risk for such infection. We are in the third decade of research with three clinical sites located at the Howard Brown Health Center, the Northwestern University HIV/AIDS Clinic and the CORE Center of Cook County Hospital. The collected data and specimens from the participants have provided and will continue to provide detailed information about the role of host and environmental factors in HIV disease. During the next funding cycle (2009 to 2014), we will support studies of the natural and treated history of HIV infection and HIV-associated disease in the era of highly active antiretroviral therapy (HAART) through standardized and detailed data and specimen collection at 6-month intervals to characterize exposures and risk factors. We will support ongoing MACS-wide research projects and initiate new projects on: behaviors enhancing transmission of HIV-1; the responses, effects, and predictors of response to HAART including the impact of illicit drug use; the effects of aging on the clinical course of HIV, HIV therapy, and response to HIV therapy; the host environment interaction between host genetics and HIV and other exposures; and the impact of aging, HAART and/or HIV infection on end-organ disease, cancer (both AIDS-related and non-related) upon long-term survival of infected men. We will contribute to each of the aims through scientific leadership, development and implementation of the overall MACS scientific agenda, retention and maintenance of the cohort and development of a state of the art facility using novel technology to conduct MACS-wide investigations of host genetics.

描述（由申请人提供）：