Multicenter AIDS Cohort Study

描述(由申请人提供)： 多中心艾滋病队列研究(MACS)的芝加哥部分由感染艾滋病毒或有感染风险的男性的代表性样本组成。我们正处于研究的第三个十年，三个临床站点分别位于霍华德·布朗健康中心、西北大学艾滋病毒/艾滋病诊所和库克县医院的核心中心。从参与者那里收集的数据和标本已经并将继续提供关于宿主和环境因素在艾滋病毒疾病中的作用的详细信息。在下一个供资周期(2009年至2014年)，我们将通过标准化和详细的数据以及每6个月收集一次样本，支持对高效抗逆转录病毒疗法(HAART)时代艾滋病毒感染和艾滋病毒相关疾病的自然和治疗史的研究，以确定暴露和风险因素的特征。我们将支持正在进行的互委会范围内的研究项目，并启动新的项目，这些项目包括：促进艾滋病毒-1传播的行为；对HAART的反应、影响和预测因素，包括非法药物使用的影响；老龄化对艾滋病毒、艾滋病毒治疗和对艾滋病毒治疗的反应的影响；宿主环境；宿主遗传学与艾滋病毒和其他暴露之间的相互作用；以及老龄化、HAART和/或艾滋病毒感染对终末器官疾病、癌症(艾滋病相关和非相关)对感染者长期生存的影响。我们将通过科学领导、制定和实施互委会的总体科学议程、保留和维护队列以及开发使用新技术在互委会范围内进行宿主遗传学研究的最先进设施，为实现每个目标做出贡献。

DESCRIPTION (provided by applicant): The Chicago component of the Multicenter AIDS Cohort Study (MACS) is composed of a representative sample of men infected with HIV or at risk for such infection. We are in the third decade of research with three clinical sites located at the Howard Brown Health Center, the Northwestern University HIV/AIDS Clinic and the CORE Center of Cook County Hospital. The collected data and specimens from the participants have provided and will continue to provide detailed information about the role of host and environmental factors in HIV disease. During the next funding cycle (2009 to 2014), we will support studies of the natural and treated history of HIV infection and HIV-associated disease in the era of highly active antiretroviral therapy (HAART) through standardized and detailed data and specimen collection at 6-month intervals to characterize exposures and risk factors. We will support ongoing MACS-wide research projects and initiate new projects on: behaviors enhancing transmission of HIV-1; the responses, effects, and predictors of response to HAART including the impact of illicit drug use; the effects of aging on the clinical course of HIV, HIV therapy, and response to HIV therapy; the host environment interaction between host genetics and HIV and other exposures; and the impact of aging, HAART and/or HIV infection on end-organ disease, cancer (both AIDS-related and non-related) upon long-term survival of infected men. We will contribute to each of the aims through scientific leadership, development and implementation of the overall MACS scientific agenda, retention and maintenance of the cohort and development of a state of the art facility using novel technology to conduct MACS-wide investigations of host genetics.