Multicenter AIDS Cohort Study

多中心艾滋病队列研究

• 批准号: 7926213
• 负责人: John P Phair
• 金额: $ 3.39万
• 依托单位: HOWARD BROWN HEALTH CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926213
• 关键词: AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Address; Adverse effects; Affect; Age; Aging; Arts; Behavior; Behavioral; Biological; Cardiovascular Diseases; Chicago; Chronic; Clinic; Clinical; Cohort Studies; Combined Modality Therapy; Competence; County Hospitals; Data; Development; Diabetes Mellitus; Disease; Disease Progression; Drug usage; Environment; Environmental Risk Factor; Evaluation; Exposure to; Funding; Genetic; HIV; HIV Infections; HIV therapy; HIV-1; Health; Highly Active Antiretroviral Therapy; Illicit Drugs; Immune; Immunologics; Incidence; Individual; Infection; Inflammation; Instruction; Investigation; Kidney Diseases; Leadership; Lipodystrophy; Liver diseases; Long-Term Effects; Maintenance; Malignant Neoplasms; Neoplasms; Neurocognitive; Organ; Outcome; Participant; Persons; Recording of previous events; Research; Research Project Grants; Resistance; Risk; Risk Factors; Role; Sampling; Specimen; Universities; age effect; antiretroviral therapy; clinical research site; cohort; cooking; design; insight; men; new technology; physical process; psychologic; response; sample collection; transmission process; vaccine development

The Chicago component of the Multicenter AIDS Cohort Study (MACS) is composed of a representative sample of men infected with HIV or at risk for such infection. We are in the third decade of research with three clinical sites located at the Howard Brown Health Center, the Northwestern University HIV/AIDS Clinic and the CORE Center of Cook County Hospital. The collected data and specimens from the participants have provided and will continue to provide detailed information about the role of host and environmental factors in HIV disease. During the next funding cycle (2009 to 2014), we will support studies of the natural and treated history of HIV infection and HIV-associated disease in the era of highly active antiretroviral therapy (HAART) through standardized and detailed data and specimen collection at 6-month intervals to characterize exposures and risk factors. We will support ongoing MACS-wide research projects and initiate new projects on: behaviors enhancing transmission of HIV-1; the responses, effects, and predictors of response to HAART including the impact of illicit drug use; the effects of aging on the clinical course of HIV, HIV therapy, and response to HIV therapy; the host environment interaction between host genetics and HIV and other exposures; and the impact of aging, HAART and/or HIV infection on end-organ disease, cancer (both AIDS-related and non-related) upon long-term survival of infected men. We will contribute to each of the aims through scientific leadership, development and implementation of the overall MACS scientific agenda, retention and maintenance of the cohort and development of a state of the art facility using novel technology to conduct MACS-wide investigations of host genetics. RELEVANCE (See instructions): The study will address transmission of HIV, the impact of HAART, its adverse effects and the interaction of therapy and aging upon the long-term survival of individuals with chronic inflammation due to HIV infection. Results will provide direction to efforts designed to reduce behaviors that enhance transmission and insights into the management of HIV-infected persons. Immunologic, virologic and genetic evaluation of men resistant to acquisition of HIV infection or demonstrating long-term non- or slow progression will aid in the development of a vaccine.

多中心艾滋病队列研究（MACS）的芝加哥部分由代表性的 感染艾滋病毒或有感染风险的男性样本。我们正处于研究的第三个十年， 位于霍华德布朗健康中心、西北大学艾滋病毒/艾滋病诊所的三个临床站点 和库克县医院的核心中心从参与者那里收集的数据和标本 已经提供并将继续提供关于东道国和环境的作用的详细信息， 艾滋病的因素。在下一个资助周期（2009至2014年），我们会资助自然环境的研究， 并在高活性抗逆转录病毒时代治疗过HIV感染史和HIV相关疾病 通过标准化和详细的数据和样本收集，每隔6个月进行一次HAART治疗， 描述暴露和风险因素。我们将支持正在进行的MACS范围内的研究项目，并启动 新项目：行为增强艾滋病毒-1的传播;的反应，影响和预测因素， 对高效抗逆转录病毒疗法的反应，包括非法药物使用的影响;衰老对艾滋病毒临床过程的影响， HIV治疗和对HIV治疗的反应;宿主遗传学和HIV之间的宿主环境相互作用 以及衰老、HAART和/或艾滋病毒感染对终末器官疾病、癌症 (both艾滋病相关和非相关）对受感染男性长期生存的影响。我们将为每一个 通过科学的领导，发展和实施整体MACS科学的目标 议程，保留和维护队列，并使用新的 技术进行MACS范围内的宿主遗传学调查。 相关性（参见说明）： 这项研究将探讨艾滋病毒的传播、高效抗逆转录病毒疗法的影响、其不良影响以及 治疗和衰老对HIV感染所致慢性炎症患者长期生存的影响。 研究结果将为旨在减少增强传播和见解的行为的努力提供方向 艾滋病毒感染者的管理。男性的免疫学、病毒学和遗传学评价 对艾滋病毒感染具有抵抗力或表现出长期无进展或进展缓慢将有助于 研制疫苗。