Multicenter AIDS Cohort Study

多中心艾滋病队列研究(MACS)芝加哥部分由一名代表组成 感染艾滋病毒或有感染风险的男子样本。我们正处于研究的第三个十年 位于西北大学艾滋病毒/艾滋病诊所霍华德·布朗健康中心的三个临床站点 以及库克县医院的核心中心。从参与者那里收集的数据和标本 已经提供并将继续提供有关主机和环境的作用的详细信息 艾滋病的致病因素。在下一个资金周期(2009至2014)，我们将支持对自然资源的研究 以及在高效抗逆转录病毒时代的艾滋病毒感染和艾滋病毒相关疾病的治疗史 治疗(HAART)通过标准化和详细的数据和样本收集，每隔6个月 描述暴露和风险因素。我们将支持正在进行的Mac范围内的研究项目，并启动 新项目：促进HIV-1传播的行为；响应、影响和预测 对HAART的反应，包括非法药物使用的影响；老龄化对艾滋病毒临床病程的影响， HIV治疗和对HIV治疗的应答；宿主遗传学与HIV之间的宿主环境相互作用 以及老龄化、抗逆转录病毒治疗和/或艾滋病毒感染对终末器官疾病、癌症的影响 (艾滋病相关和非艾滋病相关)对受感染男子长期生存的影响。我们将为每一个人做出贡献 旨在通过科学的领导，发展和实施整体的科学的互委会 议程、队列的保留和维护以及使用NORICE开发最先进的设施 在Mac范围内对宿主遗传学进行研究的技术。 相关性(请参阅说明)： 这项研究将讨论艾滋病毒的传播、HAART的影响、其不利影响以及 治疗和老龄化对艾滋病毒感染引起的慢性炎症患者的长期生存有影响。 结果将为旨在减少增强传播和洞察力的行为的努力提供方向 对艾滋病毒感染者的管理。男性的免疫学、病毒学和遗传学评估 抵抗感染艾滋病毒或表现出长期无进展或缓慢进展将有助于 疫苗的研发。

The Chicago component of the Multicenter AIDS Cohort Study (MACS) is composed of a representative sample of men infected with HIV or at risk for such infection. We are in the third decade of research with three clinical sites located at the Howard Brown Health Center, the Northwestern University HIV/AIDS Clinic and the CORE Center of Cook County Hospital. The collected data and specimens from the participants have provided and will continue to provide detailed information about the role of host and environmental factors in HIV disease. During the next funding cycle (2009 to 2014), we will support studies of the natural and treated history of HIV infection and HIV-associated disease in the era of highly active antiretroviral therapy (HAART) through standardized and detailed data and specimen collection at 6-month intervals to characterize exposures and risk factors. We will support ongoing MACS-wide research projects and initiate new projects on: behaviors enhancing transmission of HIV-1; the responses, effects, and predictors of response to HAART including the impact of illicit drug use; the effects of aging on the clinical course of HIV, HIV therapy, and response to HIV therapy; the host environment interaction between host genetics and HIV and other exposures; and the impact of aging, HAART and/or HIV infection on end-organ disease, cancer (both AIDS-related and non-related) upon long-term survival of infected men. We will contribute to each of the aims through scientific leadership, development and implementation of the overall MACS scientific agenda, retention and maintenance of the cohort and development of a state of the art facility using novel technology to conduct MACS-wide investigations of host genetics. RELEVANCE (See instructions): The study will address transmission of HIV, the impact of HAART, its adverse effects and the interaction of therapy and aging upon the long-term survival of individuals with chronic inflammation due to HIV infection. Results will provide direction to efforts designed to reduce behaviors that enhance transmission and insights into the management of HIV-infected persons. Immunologic, virologic and genetic evaluation of men resistant to acquisition of HIV infection or demonstrating long-term non- or slow progression will aid in the development of a vaccine.