Adult to Adult Living Donor Liver Transplantation

成人对成人活体供肝移植

• 批准号: 8015774
• 负责人: ROBERT A FISHER
• 金额: $ 1.93万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8015774
• 关键词: Adult; Ancillary Study; Award; Chairperson; Characteristics; Child; Childhood; Clinical Trials; Cohort Studies; Collection; Data; Data Collection; Development; Division of Cancer Epidemiology and Genetics; Donor person; Enrollment; Evaluation; Genes; Genomics; Health; Hepatectomy; Hepatic; Hepatitis C virus; Hospitals; Immune Tolerance; Immunosuppression; Infant; Length; Life; Liver; Living Donor Liver Transplantation; Living Donors; Medical; National Cancer Institute; Natural regeneration; Organ; Outcome; Patients; Peer Review; Phase; Primary carcinoma of the liver cells; Protocols documentation; Publications; Quality Control; Quality of life; Recurrence; Research; Risk; Sampling; System; Testing; Transplantation; Treatment Protocols; Universities; Virginia; cohort; experience; improved; liver function; liver transplantation; medical schools; novel strategies; patient population; prevent; programs; progression marker; prospective; psychologic; public health relevance; repository; sample collection; volunteer

DESCRIPTION (provided by applicant): Living donor liver transplantation (LDLT) was conceived as a way to increase the availability of donated organs, and was initiated in infants and children more than 2 decades ago. The Hume-Lee Liver transplant program and its directors have actively enrolled adult living liver donors and their adult liver recipients contributing significantly to all eight research aims of the adult to adult living donor liver transplant study (A2ALL) 1U01DK062531-01, awarded to Virginia Commonwealth University (VCU) on 09/17/2002. Over seven years and three phases of study in A2ALL, VCU has contributed 11% (198 of 1750 patients) of the total study patient population and 10% (108 of 1049 patients) of the prospective cohort era study patient population. VCU leads the way in Hepatocellular Carcinoma (HCC) data and sample repository collection for HCC in liver transplantation. On 03/28/2006,1R01DK069859-01A1, Genes Related to HCC progression in living donors (LD) and deceased donors (DD) transplant (GR2HCC) was awarded to the VCU liver program director and chairman of the A2ALL HCC subcommittee. The GR2HCC is nested in 6 of the 9 patient enrolling transplant centers of A2ALL utilizing the DCC of A2ALL for data collection and analysis and the Division of Cancer Epidemiology and Genetics of the National Cancer Institutes (NCI) for gene array quality control. Completion of the 3 specific aims in the very productive GR2HCC (more than 10 peer reviewed full length publication and 1/3 to 1/2 study patient enrollment) will be enhanced with the new Transplant Center recruitment. Finally, ancillary studies accompanying the main trial will improve the patient and sample repository for HCC and will increase the quality and quantities of long term living donor outcomes and quality of life study by augmenting donor patient controls with adult living liver donors of VCU liver transplant program pediatric recipients.

描述（由申请人提供）：活体肝移植（LDLT）被认为是增加捐献器官可用性的一种方法，20多年前开始在婴儿和儿童中使用。Hume-Lee肝移植项目及其负责人积极招募成人活体肝供体及其成人肝受体，为2002年9月17日授予弗吉尼亚联邦大学（VCU）的成人间活体肝移植研究（A2 ALL）1U 01 DK 062531 -01的所有八个研究目标做出了重大贡献。在A2 ALL的7年3期研究中，VCU占总研究患者人群的11%（198/1750例患者），占前瞻性队列研究患者人群的10%（108/1049例患者）。VCU在肝细胞癌（HCC）数据和肝移植中HCC的样本库收集方面处于领先地位。2006年3月28日，1 R 01 DK 069859 - 01 A1，与活体供体（LD）和已故供体（DD）移植（GR 2 HCC）中HCC进展相关的基因被授予VCU肝脏项目主任和A2 ALL HCC小组委员会主席。GR 2 HCC被嵌套在A2 ALL的9个患者登记移植中心中的6个中，利用A2 ALL的DCC进行数据收集和分析，并由美国国家癌症研究所（NCI）的癌症流行病学和遗传学部门进行基因阵列质量控制。在非常富有成效的GR 2 HCC中完成3个具体目标（超过10篇同行评审的完整出版物和1/3至1/2的研究患者入组）将通过新的移植中心招募得到加强。最后，伴随主试验的辅助研究将改善HCC的患者和样本储存库，并通过增加VCU肝移植计划儿科受者的成人活体肝供体的供体患者对照，提高长期活体供体结局和生活质量研究的质量和数量。