Early Detection of Pervasive Developmental Disorders

早期发现广泛性发育障碍

• 批准号: 8116217
• 负责人: Deborah A. Fein
• 金额: $ 20.78万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116217
• 关键词: 2 year old; Academy; Address; Adopted; Affect; Age; Algorithms; American; Autistic Disorder; Bypass; Characteristics; Child; Childhood; China; Clinical; Connecticut; Country; DSM-IV; Data; Data Set; Development; Developmental Diagnostic; Diagnosis; Diagnostic; Disease; Early Diagnosis; Early treatment; Egypt; Evaluation; Family; France; Funding; Germany; Goals; Growth; Guidelines; Health Personnel; Iceland; Intervention; Interview; Ireland; Japan; Measures; Meleagris gallopavo; Netherlands; Outcome; Parents; Pediatrics; Pervasive Development Disorder; Phenotype; Population; Population Characteristics; Population Heterogeneity; Process; Progress Reports; Property; Psychometrics; Puerto Rico; Questionnaires; Recommendation; Resources; Risk; Sampling; Scientist; Screening procedure; Siblings; Spain; Symptoms; Telephone; Testing; Toddler; Translations; Turkey bird; United States Indian Health Service; Universities; Visit; autism spectrum disorder; base; cohort; early childhood; follow-up; high risk; improved; instrument; pediatrician; public health relevance; social communication; tool; user-friendly

DESCRIPTION (provided by applicant): Early detection of Autism Spectrum Disorders (ASD) has come to be recognized as a crucial activity in promoting the best possible outcome for affected children. In our current NICHD-funded Early Detection (ED) study, for which this application is a competing continuation, we have developed an effective screening instrument, the Modified Checklist for Autism in Toddlers (M-CHAT), which is now widely used in the US, and is being studied in translation in other countries and cultures, including Japan, China, Spain, the Netherlands, France, Iceland, Ireland, Germany, Egypt, Puerto Rico and Turkey. It is being used by the Indian Health Service and is included in the American Academy of Pediatrics screening tool kit. In addition to studying the properties of this screening instrument, studying our current cohort of 16-30 month old children detected with the M-CHAT and diagnosed with ASD, has allowed us to address other questions of great theoretical and practical importance concerning early detection and development, including: characteristics of children with ASD screened from high risk vs. unselected samples, characteristics of younger siblings of children with ASD detected at age 1.5 to 2, early predictors of outcome, the application of DSM-IV symptoms to very young children, diagnostic stability through early childhood, validity of diagnostic instruments in 2-year-olds, growth parameters in early development and their relationships to outcome, and whether general developmental screening is sufficient to detect ASD. The overarching goal of this continuation is to validate a final shortened revision of the M-CHAT. This final version will be (a) brief and user-friendly, (b) easy for pediatricians to score in their offices, (c) valid for diverse populations of children, (d) valid for younger siblings, who are at high risk, and (e) ready to be recommended for universal pediatric use in the US, as well as in multiple translations in other countries. Disseminating a finalized, valid screener for early detection of ASD, which is parent- and pediatrician-friendly, will allow a large number of children to have earlier access to intervention and optimize their developmental outcomes. PUBLIC HEALTH RELEVANCE: The goal of this project is to validate a final shortened revision of the M-CHAT, a screener for autism in toddlers. This final version will be (a) brief and user-friendly, (b) easy for pediatricians to score in their offices, (c) valid for diverse populations of children, (d) valid for younger siblings, who are at high risk, and (e) ready to be recommended for universal pediatric use in the US, as well as in multiple translations in other countries. Disseminating a finalized, valid screener for early detection of ASD, which is parent- and pediatrician-friendly, will allow a large number of children to have earlier access to intervention and optimize their developmental outcomes.

描述（由申请人提供）：自闭症谱系障碍（ASD）的早期检测已被公认为促进受影响儿童最佳结果的关键活动。在我们目前的NICHD资助的早期检测（艾德）研究中，本申请是一个竞争性的延续，我们开发了一种有效的筛查工具，幼儿自闭症改良清单（M-CHAT），目前在美国广泛使用，并正在其他国家和文化中进行翻译研究，包括日本，中国，西班牙，荷兰，法国，冰岛，爱尔兰，德国，埃及，波多黎各和土耳其。它被印度卫生服务局使用，并被纳入美国儿科学会筛查工具包。除了研究这种筛查工具的特性外，研究我们当前使用M-CHAT检测并诊断患有ASD的16-30个月大儿童队列，使我们能够解决有关早期检测和发展的其他具有重要理论和实践意义的问题，包括：从高风险与低风险样本中筛选的ASD儿童的特征，在1.5至2岁时检测到的ASD儿童的弟弟妹妹的特征，结果的早期预测因素，DSM-IV症状在幼儿中的应用，早期儿童诊断的稳定性，2岁儿童诊断工具的有效性，早期发育的生长参数及其与结果的关系，以及一般发育筛查是否足以检测ASD。该延续的总体目标是确认M-CHAT的最终缩短版本。最终版本将（a）简明易用，（B）便于儿科医生在其办公室进行评分，（c）适用于不同儿童人群，（d）适用于高风险的弟弟妹妹，（e）准备推荐在美国普及儿科使用，以及在其他国家进行多种翻译。传播一个最终确定的、有效的、对父母和儿科医生友好的ASD早期检测筛查工具，将使大量儿童能够更早地获得干预，并优化他们的发育结果。公共卫生相关性：该项目的目标是验证M-CHAT的最终缩短版本，M-CHAT是幼儿自闭症筛查工具。最终版本将（a）简明易用，（B）便于儿科医生在其办公室进行评分，（c）适用于不同儿童人群，（d）适用于高风险的弟弟妹妹，（e）准备推荐在美国普及儿科使用，以及在其他国家进行多种翻译。传播一个最终确定的、有效的、对父母和儿科医生友好的ASD早期检测筛查工具，将使大量儿童能够更早地获得干预，并优化他们的发育结果。