Integrating Prenatal Care to Reduce HIV/STDs Among Teens: A Translational Study

整合产前护理以减少青少年艾滋病毒/性病：一项转化研究

• 批准号: 8066158
• 负责人: Jonathan N. Tobin
• 金额: $ 19.59万
• 依托单位: CLINICAL DIRECTORS NETWORK, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-17 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8066158
• 关键词: AIDS prevention; Academic Medical Centers; Acquired Immunodeficiency Syndrome; Adolescent; Affect; Age; Alcohols; Area; Assertiveness; Behavior; Behavioral; Biological; Birth; Breast Feeding; Build-it; Caring; Characteristics; Child; Childbirth; Cities; Clinical; Clinical Research; Clinical Services; Clinics and Hospitals; Communication; Communities; Community Health Centers; Controlled Environment; Development; Ecosystem; Effectiveness; Effectiveness of Interventions; Elements; Evaluation; Evidence based program; Family; Family Relationship; First Pregnancy Trimester; Gestational Age; HIV; HIV Infections; Health; Health Personnel; High Risk Woman; Hypertension; Incidence; Individual; Institution; Intervention; Intervention Trial; Knowledge; Latina; Leadership; Learning; Low Birth Weight Infant; Measurement; Measures; Mediation; Mental Depression; Mental disorders; Modeling; Motivation; National Institute of Mental Health; New York; New York City; Nurse Midwives; Outcome; Parenting behavior; Patients; Peer Group; Perinatal; Physician Assistants; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Premature Labor; Prenatal care; Prevention Research; Prevention program; Preventive Intervention; Probability; Process; Program Effectiveness; Provider; Public Health; Randomized; Readiness; Reducing diet; Reimbursement Mechanisms; Relative (related person); Reporting; Reproductive Health; Research; Research Personnel; Resources; Risk; Risk Assessment; Risk Behaviors; Risk Reduction; Schedule; Services; Sexuality; Sexually Transmitted Diseases; Site; Social Environment; Structure; System; Systems Theory; Teenagers; Testing; Time; Tobacco; Training; Translating; Translations; United States; Universities; Woman; Work; aged; base; beneficiary; clinical practice; condoms; design; disorder prevention; disorder risk; effective intervention; efficacy trial; flexibility; group intervention; health disparity; high risk; high risk sexual behavior; improved; innovation; meetings; member; metropolitan; peer; practice-based research network; pregnant teen; prenatal; prevent; programs; prospective; psychosocial; satisfaction; self esteem; sex risk; skills; standard of care; success; translational study; transmission process; uptake

DESCRIPTION (provided by applicant): The long-term objective of this study is to reduce risk for HIV and other sexually transmitted diseases (STDs) during and after pregnancy among adolescents and young women (aged 14-19) receiving prenatal care in 14 Community Health Centers (CHCs) serving predominantly Black and Latina communities in the New York City Metropolitan area. We will evaluate an innovative model of group prenatal care that integrates HIV prevention (CenteringPregnancy Plus, CP+) and has already yielded favorable biological and behavioral outcomes in a large NIMH-sponsored randomized controlled efficacy trial. Specific aims are to: (1) Translate an efficacious HIV prevention intervention to 14 CHCs; (2) Test the effectiveness of this intervention by (a) examining behavioral and biological outcomes via prospective measurement throughout the prenatal period and up to one year postpartum (N=1400), and (b) identifying potential mechanisms of the effects of group prenatal care, using Bronfenbrenner's Ecological Systems Theory as a guiding framework; and (3) Conduct a rigorous process evaluation to identify factors that influence the uptake, fidelity, and sustainability of this intervention. Using a clustered randomized controlled design, CHCs will be randomly assigned to group care or individual standard of care. We hypothesize that CP+ will be effectively translated to CHCs, and that it will result in significant reductions in HIV-related risk behaviors, significantly lower rates of STDs and repeat pregnancies, as well as improvements in perinatal outcomes. While extensive resources have been devoted to efficacy trials, fewer resources have been devoted to identify the effectiveness of programs implemented in "real world" settings, such as CHCs, where one in ten women - including many at highest risk for HIV/STDs -- receive prenatal care. The proposed research is responsive to the PA-01-123, seeking to support multi-site collaborative intervention trials. This represents an important advance in interdisciplinary HIV prevention research for adolescent women: integrating a theoretically-driven and empirically-validated program for HIV/STD prevention into prenatal care is a promising way to provide sustainable care and disease prevention in a culturally-tailored setting. These underserved patients and the clinicians who care for them represent the ideal beneficiaries of translating clinical research into clinical practice for the reduction of risk and transmission of HIV and other STDs, as well as the elimination of health disparities.

描述（由申请人提供）：本研究的长期目标是降低在14个社区卫生中心（CHCs）接受产前护理的青少年和年轻妇女（14-19岁）在怀孕期间和之后感染艾滋病毒和其他性传播疾病（std）的风险，这些中心主要服务于纽约市大都市区的黑人和拉丁裔社区。我们将评估一种整合HIV预防的创新群体产前护理模式（CenteringPregnancy Plus, CP+），该模式已经在nimh赞助的一项大型随机对照疗效试验中产生了良好的生物学和行为学结果。具体目标是：(1)将有效的艾滋病毒预防干预措施转化为14个CHCs；(2)以Bronfenbrenner的生态系统理论为指导框架，通过(a)在整个产前期和产后一年（N=1400）的前瞻性测量来检查行为和生物学结果，以及(b)确定群体产前护理效果的潜在机制，来测试这种干预的有效性；(3)进行严格的过程评估，以确定影响该干预措施的吸收、保真度和可持续性的因素。采用聚类随机对照设计，CHCs将被随机分配到群体护理或个人标准护理。我们假设CP+将有效地转化为CHCs，并且它将导致hiv相关风险行为的显著减少，性病和重复妊娠的发生率显著降低，以及围产期结局的改善。虽然大量的资源用于疗效试验，但很少有资源用于确定在“现实世界”环境中实施的方案的有效性，例如CHCs，其中十分之一的妇女-包括许多艾滋病毒/性病风险最高的妇女-接受产前护理。拟议的研究响应PA-01-123，寻求支持多站点协作干预试验。这代表了青少年妇女跨学科艾滋病毒预防研究的重要进展：将理论驱动和经验验证的艾滋病毒/性病预防计划整合到产前护理中，是在文化定制环境中提供可持续护理和疾病预防的有希望的方法。这些得不到充分服务的病人和照顾他们的临床医生是将临床研究转化为临床实践以减少艾滋病毒和其他性传播疾病的风险和传播以及消除健康差距的理想受益者。

项目成果

Associations between intimate partner violence profiles and mental health among low-income, urban pregnant adolescents.

低收入城市怀孕青少年亲密伴侣暴力概况与心理健康之间的关联。

• DOI: 10.1186/s12884-019-2256-0
• 发表时间: 2019
• 期刊: BMC pregnancy and childbirth
• 影响因子: 3.1
• 作者: Thomas,JordanL;Lewis,JessicaB;Martinez,Isabel;Cunningham,ShaynaD;Siddique,Moiuri;Tobin,JonathanN;Ickovics,JeannetteR
• 通讯作者: Ickovics,JeannetteR

Intergenerational Consequences: Women's Experiences of Discrimination in Pregnancy Predict Infant Social-Emotional Development at 6 Months and 1 Year.

代际后果：女性在怀孕期间遭受歧视的经历可预测婴儿 6 个月和 1 岁时的社会情感发展。

• DOI: 10.1097/dbp.0000000000000529
• 发表时间: 2018
• 期刊: Journal of developmental and behavioral pediatrics : JDBP
• 作者: Rosenthal,Lisa;Earnshaw,ValerieA;Moore,JoanM;Ferguson,DarrahN;Lewis,TenéT;Reid,AlleciaE;Lewis,JessicaB;Stasko,EmilyC;Tobin,JonathanN;Ickovics,JeannetteR
• 通讯作者: Ickovics,JeannetteR