Molecular and spatial characterization of drug resistance in human ovarian cancer

卵巢癌是西方女性中最致命的妇科癌症。虽然最初对化疗有反应，但耐药性通常在几个月内发展。我们之前在最常见的卵巢癌中记录了新的耐药机制，在这项研究中，我们将绘制它们在患者体内的分布。我们还将研究卵巢癌对一类新的重要抗癌药物PARP抑制剂的耐药机制。

Ovarian cancer is the most deadly gynecologic cancer in Western women. Although initially responsive to chemotherapy, drug resistance commonly evolves in a matter of months. We previously documented novel mechanisms of drug resistance in the most common form of ovarian cancer and in this study we will map their distribution within patients. We will also investigate mechanisms of resistance to a new important class of anti-cancer drugs in ovarian cancer, the PARP inhibitors.