Molecular and spatial characterization of drug resistance in human ovarian cancer

人类卵巢癌耐药性的分子和空间特征

• 批准号: nhmrc : GNT1161198
• 金额: $ 113.77万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-spatial-characterization-ovarian-cancer/1379161
• 关键词: Molecular; spatial; characterization; drug; resistance

Ovarian cancer is the most deadly gynecologic cancer in Western women. Although initially responsive to chemotherapy, drug resistance commonly evolves in a matter of months. We previously documented novel mechanisms of drug resistance in the most common form of ovarian cancer and in this study we will map their distribution within patients. We will also investigate mechanisms of resistance to a new important class of anti-cancer drugs in ovarian cancer, the PARP inhibitors.

卵巢癌是西方女性最致命的妇科癌症。虽然最初对化疗有反应，但耐药性通常在几个月内就会产生。我们以前记录了最常见的卵巢癌耐药的新机制，在这项研究中，我们将绘制它们在患者中的分布。我们还将研究卵巢癌中一类新的重要抗癌药物PARP抑制剂的耐药机制。