Chemotherapy Adherence Decision Making In Early Stage Breast Cancer

早期乳腺癌化疗依从性决策

• 批准号: 7918154
• 负责人: Jessica Wells
• 金额: $ 2.86万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7918154
• 关键词: Adherence; Adverse effects; African American; Age Factors; American Cancer Society; Behavior; Behavioral; Benefits and Risks; Breast Cancer Treatment; Cancer Etiology; Caring; Caucasians; Caucasoid Race; Cessation of life; Complex; Data Collection; Decision Making; Decision Modeling; Demographic Factors; Development; Diagnosis; Disease; Early Diagnosis; Early treatment; Epidemiologic Studies; Equipment and supply inventories; Goals; Health; Health Personnel; Health Services Accessibility; Healthy People 2010; Intervention; Intravenous; Knowledge; Literature; Localized Disease; Malignant Neoplasms; Malignant neoplasm of lung; Measures; Mental Depression; Mission; Modeling; National Institute of Nursing Research; Outcome; Patients; Physicians; Population; Population Study; Postdoctoral Fellow; Predisposition; Prevalence; Procedures; Process; Prospective Studies; Provider; Questionnaires; RQ2; Race; Recommendation; Religion and Spirituality; Research; Research Design; Research Project Grants; Review Literature; Role; Sampling; Science; Severity of illness; Social Interaction; Social support; Staging; Stressful Event; Survival Rate; Symptoms; Testing; Training; Treatment Protocols; Trust; United States; Woman; base; breast cancer diagnosis; chemotherapy; coping; demographics; design; ethnic difference; experience; health belief; health disparity; help-seeking behavior; interest; malignant breast neoplasm; mortality; programs; prospective; public health relevance; public health research; racial difference; research study; skills; sound; statistics; treatment adherence; treatment effect

DESCRIPTION (provided by applicant): This study seeks to describe the factors that influence the decision making of African American and Caucasian women with early stage breast cancer to adhere to recommended chemotherapy treatment. The diagnosis of breast cancer is a very stressful event, requiring the woman to make multiple decisions about her care. However, their decisions may or may not be consistent with the recommendations of the healthcare provider. Because of ethnic differences observed in the treatment and survival between Caucasian and African American women with breast cancer (2-4), the extent to which adherence rates and the variables that effect treatment decision making in both groups must be better understood. The specific aims of this study are: 1. to examine differences in adherence to chemotherapy between African-American and Caucasian women with early stage breast cancer in relation to socio-demographic factors, social interaction factors, cancer experience, breast cancer knowledge, and health beliefs; and 2. to explore relationships among socio-demographic factors, social interaction factors, cancer experience, breast cancer knowledge, and health beliefs as predictors of adherence to chemotherapy in African American and Caucasian women with early stage breast cancer. This prospective predictive study will use a sample of 120 women to identify significant predictors and ethnic differences of chemotherapy treatment decision making. A Demographics Measure, Trust in Physician Scale, Norbeck Social Support Questionnaire, the Pargment Religious Coping Scale, the Comprehensive Breast Cancer Related Knowledge Scale, Memorial Symptom Assessment Scale Short Form, the Powe Fatalism Inventory, Center for Epidemiologic Studies-Depression and the Champion Health Belief Model Scale will be used for data collection. The National Institute of Nursing Research is interested in research that identify the factors that influence decision making that results in behavioral changes that promote health and to define the behaviors that support adherence to treatment for complex diseases(5). This study is well aligned with NINR's mission as it seeks to accomplish my long term goal to build on the necessary research needed for patients in their decision making process in order to promote positive health outcomes and reduce health disparities seen in African American women with breast cancer. The relevance to public health of the research is to reduce health disparities seen in survival outcomes among African American women with breast cancer. An overarching goal of Healthy People 2010 is to eliminate health disparities, specifically racial differences seen in cancer survival. PUBLIC HEALTH RELEVANCE: Training goals: To acquire the knowledge and skills related to the study of decision making in women with breast cancer in order to conduct scientifically sound research. My research will focus on the factors that influence African American women with breast cancer to terminate their recommended treatment early; given this population study has a high mortality rate from breast cancer. This goal will be accomplished by developing relevant research question on the science of treatment adherence and the decision making process of women with breast cancer, based on a theoretical framework and the current body of literature, designing and implementing a research project, analyzing the results with appropriate statistical procedures ,and disseminating the findings in the scientific literature.

描述（由申请人提供）：本研究旨在描述影响患有早期乳腺癌的非裔美国人和白人女性坚持推荐的化疗治疗决策的因素。乳腺癌的诊断是一件非常有压力的事件，需要女性就她的护理做出多个决定。然而，他们的决定可能与医疗保健提供者的建议一致，也可能不一致。由于在白人和非裔美国乳腺癌女性的治疗和生存方面观察到种族差异 (2-4)，必须更好地了解两组的依从率和影响治疗决策的变量的程度。本研究的具体目的是： 1. 探讨非裔美国和白人早期乳腺癌女性在化疗依从性方面与社会人口因素、社会互动因素、癌症经历、乳腺癌知识和健康信念相关的差异； 2. 探讨社会人口因素、社会互动因素、癌症经历、乳腺癌知识和健康信念之间的关系，作为患有早期乳腺癌的非裔美国和白人女性坚持化疗的预测因素。这项前瞻性预测研究将使用 120 名女性样本来确定化疗治疗决策的显着预测因素和种族差异。人口统计量表、对医生的信任量表、诺贝克社会支持问卷、帕格门特宗教应对量表、综合乳腺癌相关知识量表、纪念症状评估量表简表、鲍威宿命论量表、流行病学研究中心抑郁症和冠军健康信念模型量表将用于数据收集。美国国家护理研究所感兴趣的研究是确定影响决策的因素，从而导致促进健康的行为改变，并确定支持坚持复杂疾病治疗的行为(5)。这项研究与 NINR 的使命非常一致，因为它旨在实现我的长期目标，即以患者决策过程中所需的必要研究为基础，以促进积极的健康结果并减少非裔美国乳腺癌女性的健康差异。该研究与公共卫生的相关性在于减少非裔美国乳腺癌女性生存结果的健康差异。 《2010 年健康人民》的首要目标是消除健康差异，特别是癌症存活率方面的种族差异。公共卫生相关性： 培训目标： 获得与乳腺癌女性决策研究相关的知识和技能，以便进行科学合理的研究。我的研究将集中于影响非裔美国乳腺癌女性尽早终止推荐治疗的因素；鉴于这项人口研究显示乳腺癌死亡率很高。这一目标将通过以下方式实现：基于理论框架和现有文献，开发关于乳腺癌女性治疗依从性和决策过程的科学相关研究问题，设计和实施研究项目，使用适当的统计程序分析结果，并在科学文献中传播研究结果。