Assessing Workplace Phthalate Exposures Among Massage Therapy Students

评估按摩治疗学生的工作场所邻苯二甲酸盐暴露情况

• 批准号: 7916455
• 负责人: Victoria M Pak
• 金额: $ 4.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916455
• 关键词: Age; Animals; Anus; Area; Biological; Biological Markers; Biological Monitoring; Board Certification; Body mass index; Breathing; Chemical Exposure; Chemicals; Cream; Cross-Sectional Studies; Cryptorchidism; Data Analyses; Dermal; Development; Dibutyl Phthalate; Dose; Engineering; Environmental air flow; Exposure to; Female; Female of child bearing age; Fetus; Frequencies; General Population; Goals; Guidelines; Handwashing; Health; Hormones; Human; Individual; Infant; Infertility; Intervention; Knowledge; Lead; Linear Regressions; Lotion; Malignant neoplasm of testis; Massage; Measurement; Measures; Occupational; Occupational Exposure; Occupational Groups; Oils; Patient Self-Report; Persons; Philadelphia; Plastics; Policies; Population; Public Health; Questionnaires; Regression Analysis; Repression; Reproductive Health; Research; Risk; Route; Schools; Self Care; Skin; Smoking; Source; Students; Techniques; Texture; Therapeutic; Time; Tissues; Urine; Work; Workplace; absorption; air sampling; base; consumer product; diethylphthalate; exhaust; fetal; flexibility; male; men; monobutyl phthalate; penis; phthalates; prenatal; reproductive development; research study; resilience; response; shift work; statistics; urinary

DESCRIPTION (provided by applicant): Phthalates exposures are ubiquitous in the general population due to their widespread usage in many consumer products. Higher prenatal levels of exposure to phthalates are associated with an increased risk for adverse male fetal reproductive development. Massage therapists are a potential occupational group at risk for phthalate exposure as a result of their high exposure to numerous products containing these chemicals. A better understanding of the source and extent of phthalate exposure from products used in the worksetting is needed, and guidelines for interventions (i.e. phthalate-free products) may be necessary to reduce exposures and protect this expanding worker population. The overarching goal of this research study is to explore the extent of phthalate exposure related to skincare products such as lotions, oils, and creams used in therapeutic massage. This work will be conducted in partnership with two large therapeutic massage schools in the Philadelphia area, one of which has a phthalate-free policy. The specific aims for the proposed study are:1) To determine the extent of occupational exposure of massage therapist students to phthalates in the work setting; 2)To determine the levels of the urinary biomarkers MEP and MBP, the main metabolites of Diethyl Phthalate (DEP) and Dibutyl Phthalate (DBP) in massage therapist students, while controlling for personal product usage, age, body mass index (BMI), and smoking; 3) To compare the urinary biomarker levels of MEP and MBP and personal DEP and DBP air samples collected across the work shift among massage therapist students who use phthalate-free alternatives with massage therapist students who do not acknowledge using phthalate-free products; 4)To explore the relationship between self- reported engineering controls (local exhaust ventilation, open windows) and work practices (frequency of hand washing, amount of product usage) to urinary biomarker levels of MEP and MBP among users of phthalate-containing skincare products. This cross-sectional study involves administering a questionnaire and obtaining pre-and post-shift urine as well as cross-shift air samples in the workplace among the two massage schools. Data analysis will involve descriptive statistics, spearman coefficient correlations, and stepwise multiple linear regression analysis. This knowledge will be useful for understanding further the sources and extent of exposures among massage therapists and can inform the development of public health guidelines to reduce occupational levels of exposure to substances that have the potential to be harmful to reproductive health.

描述（由申请人提供）：由于邻苯二甲酸酯广泛用于许多消费品中，因此其暴露在普通人群中普遍存在。产前邻苯二甲酸酯暴露水平较高与男性胎儿生殖发育不良风险增加相关。按摩治疗师是一个潜在的职业群体在邻苯二甲酸酯暴露的风险，因为他们高暴露于含有这些化学品的许多产品。需要更好地了解工作环境中使用的产品中邻苯二甲酸酯暴露的来源和程度，可能需要制定干预指南（即无邻苯二甲酸酯产品）以减少暴露并保护这一不断扩大的工人群体。本研究的总体目标是探索与治疗按摩中使用的护肤产品（如乳液、油和面霜）相关的邻苯二甲酸酯暴露程度。这项工作将与费城地区的两所大型治疗按摩学校合作进行，其中一所学校有无邻苯二甲酸酯政策。本研究的具体目的是：1）确定按摩治疗师学生在工作环境中邻苯二甲酸酯的职业暴露程度; 2）确定按摩治疗师学生尿生物标志物MEP和MBP的水平，MEP和MBP是邻苯二甲酸二乙酯（DEP）和邻苯二甲酸二丁酯（DBP）的主要代谢物，同时控制个人产品使用，年龄，体重指数（BMI）和吸烟; 3）比较使用不含邻苯二甲酸酯替代品的按摩治疗师学生与不承认使用不含邻苯二甲酸酯产品的按摩治疗师学生之间在轮班期间收集的MEP和MBP以及个人DEP和DBP空气样本的尿液生物标志物水平; 4）探索自我报告的工程控制（局部排气通风、打开窗户）和工作实践（洗手频率、产品使用量）与含邻苯二甲酸酯的护肤产品的使用者中MEP和MBP的尿生物标志物水平之间的关系。这项横断面研究涉及管理的问卷调查，并获得前和后转移的尿液以及交叉转移的空气样本在工作场所之间的两个按摩学校。资料分析包括描述性统计、斯皮尔曼相关系数及逐步多元线性回归分析。这方面的知识将有助于进一步了解按摩治疗师接触的来源和程度，并可为制定公共卫生准则提供信息，以减少接触可能对生殖健康有害的物质的职业水平。

项目成果

How to reduce DEHP in your NICU: a plan of simple steps to promote change.

如何减少 NICU 中的 DEHP：促进变革的简单步骤计划。

• DOI: 10.1891/0730-0832.25.6.447
• 发表时间: 2006
• 期刊: Neonatal network : NN
• 作者: Pak,VictoriaM;Briscoe,Valerie;McCauley,LindaA
• 通讯作者: McCauley,LindaA

Thiuram allergy--a potential dermal allergy among health care workers.

秋兰姆过敏——医护人员中潜在的皮肤过敏。

• DOI: 10.3928/08910162-20090401-08
• 发表时间: 2009
• 期刊: AAOHN journal : official journal of the American Association of Occupational Health Nurses
• 作者: Green-McKenzie,Judith;Pak,VictoriaM;Crawford,GlenH
• 通讯作者: Crawford,GlenH

Controversy: neonatal exposure to plasticizers in the NICU.

争议：新生儿重症监护室中的新生儿接触塑化剂。

• DOI: 10.1097/01.nmc.0000281965.45905.c0
• 发表时间: 2007
• 期刊: MCN. The American journal of maternal child nursing
• 作者: Pak,VictoriaM;Nailon,ReginaE;McCauley,LindaA
• 通讯作者: McCauley,LindaA