Postpartum Depressive Symptoms: A Search for a Biologic Marker

产后抑郁症状：寻找生物标记

• 批准号: 7776975
• 负责人: LINDSEY GARFIELD
• 金额: $ 3.8万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-16 至 2011-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7776975
• 关键词: 21 year old; Accounting; Affect; Age; Aggressive behavior; Anxiety; Behavior; Biological; Biological Factors; Biological Markers; Brain; Breast Feeding; Cardiovascular Diseases; Caring; Cessation of life; Child; Clinical; Clinical Research; Conflict (Psychology); Data; Detection; Diagnosis; Diagnostic; Diagnostic Procedure; Early Diagnosis; Emotions; Enrollment; Environment; Epidemiologic Studies; Epidemiology; Equilibrium; Face; Failure; Foundations; Funding; Genetic; Goals; Growth and Development function; Health; Health behavior; Hormones; Hydrocortisone; Illinois; Immune system; Infant; Infant Care; Infanticide; Knowledge; Lactation; Link; Literature; Logistic Regressions; Major Depressive Disorder; Maternal Behavior; Measures; Mediation; Mediator of activation protein; Medical; Mental Depression; Modeling; Mothers; Murder; National Institute of Nursing Research; Neonatal Intensive Care Units; Neurosecretory Systems; Nurses; Outcome; Oxytocin; Pain; Parenting behavior; Physiological; Physiological Processes; Posterior Pituitary Gland; Postpartum Depression; Postpartum Period; Procedures; Process; Quality of life; Questionnaires; Regulation; Reporting; Research; Research Personnel; Research Proposals; Research Training; Risk; Role; Rosemary; Shock; Signs and Symptoms; Specimen; Stress; Stressful Event; Suicide; Touch sensation; United Kingdom; United States; United States National Institutes of Health; Universities; Very Low Birth Weight Infant; Weight; Woman; acute stress; adverse outcome; base; biopsychosocial; career; depressive symptoms; design; experience; hypothalamic-pituitary-adrenal axis; innovation; instrument; killings; paraventricular nucleus; physiologic model; programs; psychologic; psychosocial; research study; response; salivary assay; skills; social; stressor

DESCRIPTION (provided by applicant): This research proposal is an opportunity for me to achieve my short and long-term objectives. Currently, I am in my second year of the doctoral program at the University of Illinois and my long-term objectives include furthering my research skills to lay the foundation for my career as a nurse researcher and educator. The primary aim of my dissertation research proposal is to examine the relationships among neuroendocrine mechanisms (oxytocin and cortisol) and a physiological process (post part urn depressive symptoms) in women with very low birth weight infants who are cared for in the Neonatal Intensive Care Unit. Postpartum depressive symptoms affect 10-50% of mothers and causing mothers and infants adverse outcomes. Contributing factors (such as biologic and psychologic factors, health behaviors, and stress) affect postpartum depressive symptoms through the mediation of neuroendocrine mechanisms (cortisol and oxytocin). Cortisol is the hormone that is released during stressful events and has conflicting results on its relationship with depression. Another neuroendocrine mechanism that initiates mothering behavior is oxytocin, which is released during labor, breastfeeding, and touch. Oxytocin is inhibited by emotion, anxiety, and pain. Oxytocin has never been examined with postpartum depression and this is a gap in our current knowledge of this condition. Cortisol and oxytocin are balancing hormones and will be measured from the same specimens. Many researchers (including myself) speculate that oxytocin and cortisol will have a relationship with postpartum depressive symptoms. My study will be part of a primary study conducted by Diane Holditch-Davis, R01 NR009418, and funded by the National Institutes of Health. My study will use an exploratory cross sectional design with multiple and possible logistic regression to examine the aim stated above. Instruments and procedures for this research include salivary assays (for oxytocin and cortisol), the Center for Epidemiologic Studies Depression Scale (for postpartum depressive symptoms), Parental Stressor Scales (for stress), and questionnaires to assess biologic and psychologic factors and health behaviors. Data will be collected at enrollment into the primary study. The knowledge gained from this proposed research will further describe social and biological relationships with postpartum depressive symptoms. Once these relationships are established, a potential biologic marker (for example, oxytocin and cortisol) can be used as a diagnostic procedure for postnatal depression. This will benefit up to 50% of mothers with this condition that are not currently diagnosed.

描述(申请人提供)：这份研究计划是我实现短期和长期目标的机会。目前，我在伊利诺伊大学攻读博士课程的第二年，我的长期目标包括进一步提高我的研究技能，为我作为护士研究员和教育工作者的职业生涯奠定基础。我的论文研究提案的主要目的是研究在新生儿重症监护病房接受护理的极低出生体重儿的神经内分泌机制(催产素和皮质醇)与生理过程(部分骨盆抑郁症状)之间的关系。产后抑郁症状影响10-50%的母亲，并造成母婴不良结局。促成因素(如生物和心理因素、健康行为和压力)通过神经内分泌机制(皮质醇和催产素)影响产后抑郁症状。皮质醇是一种在压力事件中释放的荷尔蒙，在它与抑郁症的关系上有相互矛盾的结果。另一种启动母爱行为的神经内分泌机制是催产素，它在分娩、哺乳和触摸过程中释放。催产素受到情绪、焦虑和疼痛的抑制。催产素从来没有在产后抑郁症中被检测过，这是我们目前对这种情况的了解的一个空白。皮质醇和催产素是平衡荷尔蒙，将从相同的样本中进行测量。许多研究人员(包括我自己)推测，催产素和皮质醇将与产后抑郁症状有关。我的研究将是Diane Holditch-Davis进行的主要研究的一部分，R01 NR009418，由美国国立卫生研究院资助。我的研究将使用探索性横断面设计和多重可能的Logistic回归来检验上述目的。这项研究的工具和程序包括唾液分析(催产素和皮质醇)、流行病学研究中心抑郁量表(产后抑郁症状)、父母压力源量表(压力)，以及评估生物和心理因素和健康行为的问卷。数据将在注册进入初级研究时收集。从这项拟议的研究中获得的知识将进一步描述产后抑郁症状与社会和生物学的关系。一旦建立了这些关系，一个潜在的生物标记物(例如催产素和皮质醇)就可以用作产后抑郁症的诊断程序。这将使目前未确诊的高达50%的患有这种疾病的母亲受益。

项目成果

Depressive symptoms in the second trimester relate to low oxytocin levels in African-American women: a pilot study.

• DOI: 10.1007/s00737-014-0437-4
• 发表时间: 2015-02
• 期刊: ARCHIVES OF WOMENS MENTAL HEALTH
• 影响因子: 4.5
• 作者: Garfield, Lindsey;Giurgescu, Carmen;Carter, C. Sue;Holditch-Davis, Diane;McFarlin, Barbara L.;Schwertz, Dorie;Seng, Julia S.;White-Traut, Rosemary
• 通讯作者: White-Traut, Rosemary