Arizona Neurological Emergencies Treatment Trials Network

亚利桑那州神经紧急情况治疗试验网络

• 批准号: 7807901
• 负责人: KURT R DENNINGHOFF
• 金额: $ 19.41万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7807901
• 关键词: Accident and Emergency department; Acute; Address; Area; Arizona; Clinical; Clinical Research; Clinical Trials; Community Hospitals; Computer Architectures; Contracts; Data; Data Coordinating Center; Development; Effectiveness; Elements; Emergency Care; Emergency Medicine; Emergency Situation; Emergency treatment; Enrollment; Ensure; Environment; Future; Health; Hispanics; Hospitals; Human Resources; Individual; Injury; Institutes; Interdisciplinary Study; Intervention; Intervention Trial; Intramuscular; Intravenous; Latino; Lorazepam; Michigan; Midazolam; Minority; Modeling; Monitor; Monitoring Clinical Trials; Native Americans; Neurological emergencies; Neurologist; Neurology; Neurosurgeon; Notification; Operative Surgical Procedures; Outcome; Outcome Assessment; Participant; Patient Care; Patients; Phase; Physicians; Population Characteristics; Progesterone; Provider; Quality of Care; Recruitment Activity; Research; Research Ethics Committees; Research Infrastructure; Research Personnel; Resources; Rural; Rural Hospitals; Scientist; Screening procedure; Services; Site; Societies; Status Epilepticus; Stroke; Structure; System; Telemedicine; Testing; Therapeutic; Thinking; Time; TimeLine; Training; Training and Education; Traumatic Brain Injury; Underrepresented Minority; Underserved Population; United States; United States National Institutes of Health; Universities; Urban Hospitals; demographics; design; electronic data; experience; human subject protection; innovation; member; metropolitan; nervous system disorder; neurosurgery; novel strategies; organizational structure; pediatric trauma; programs; response; tool; trauma centers; treatment trial; volunteer

DESCRIPTION (provided by applicant): Emergencies caused by acute neurological disorders and injuries are common and the health burden of these conditions to patients and society is well documented. The outcome of many neurological disorders is often determined within the first minutes after onset and intervention in the emergency department or even prior to emergency department arrival may be necessary to provide meaningful benefit. The optimal treatments for these conditions are not well described, in part because the clinical research in the United States has not conducted many intervention trials targeting the earliest phases of treatment. Another obstacle facing investigators is the ability to enroll a sufficient number of volunteers to obtain statistical significance in testing the intervention. To overcome these challenges, the National Institutes of Neurological Disease and Strokes (NINDS) endeavors to create a wide network of major and community hospitals, referred to as the "hub and spoke" model. This model seeks to capture a wide socio-demographic profile including minority and underserved individuals, while obviating protracted timelines implicit in clinical trials. NINDS has selected the Department of Emergency Medicine at the University of Michigan as the Clinical Coordinating Center, and a data coordinating site will be identified. Our team will contribute significantly to this network by incorporating three major hospitals from Arizona's two metropolitan areas and four rural hospitals. The hub and spoke design of the Arizona Neurological Emergencies Treatment Trials Network (AzNETT) will be enhanced by incorporating rural hospitals already included in the University of Arizona's Telemedicine Program. Through this growing infrastructure, we will be able to investigate the effectiveness of new therapies in a broader range of service environments, while striving to augment the quality of patient care. The key elements of this structure will include an interdisciplinary team of emergency physicians, neurologists, neurosurgeons, coordinators, program managers and information technologists with specific expertise in the conduct of emergent clinical trials. Team members in both the hub and spoke sites have demonstrated a long term commitment to advancing the national research infrastructure as it relates to the interdisciplinary study of emergent illness.

描述（由申请人提供）：由急性神经系统疾病和损伤引起的紧急情况是常见的，这些疾病对患者和社会的健康负担是有充分记录的。许多神经系统疾病的预后通常在发病后的头几分钟内确定，在急诊科甚至在急诊科到达之前进行干预可能是必要的，以提供有意义的益处。对这些疾病的最佳治疗方法没有很好地描述，部分原因是美国的临床研究没有针对治疗的早期阶段进行许多干预试验。研究人员面临的另一个障碍是能否招募足够数量的志愿者来获得干预试验的统计显著性。为了克服这些挑战，国家神经疾病和中风研究所（NINDS）努力建立一个由大型医院和社区医院组成的广泛网络，被称为“中心和辐条”模式。该模型旨在捕捉广泛的社会人口特征，包括少数民族和服务不足的个体，同时避免临床试验中隐含的拖延时间。NINDS已选择密歇根大学急诊医学系作为临床协调中心，并将确定一个数据协调地点。我们的团队将通过整合亚利桑那州两个大都市地区的三家主要医院和四家农村医院，为这一网络作出重大贡献。亚利桑那神经急症治疗试验网络（AzNETT）的中心和辐形设计将通过整合已经纳入亚利桑那大学远程医疗计划的农村医院而得到加强。通过这种不断发展的基础设施，我们将能够在更广泛的服务环境中研究新疗法的有效性，同时努力提高患者护理的质量。这一结构的关键要素将包括一个由急诊医生、神经科医生、神经外科医生、协调员、项目经理和信息技术专家组成的跨学科团队，他们在开展紧急临床试验方面具有特定的专业知识。中心和辐条站点的团队成员都表现出对推进国家研究基础设施的长期承诺，因为它与紧急疾病的跨学科研究有关。