ASSEMBLY OF A PRE-POLARIZER BASED ON A NARROW-BORE MAGNET

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 JJ van der Klink博士和A Comment博士在洛桑的实验室中建造并演示了预偏振器。该设计在最近的两篇论文“用于溶解动态核极化的140千兆赫预偏振器”J Chem Phys 2008；128：241102和“通过溶解DNP产生超过100ml的高浓度超极化溶液”J Magn Reson中进行了描述。2008；194：152-5。这一RR长期以来一直对临床研究的13C核磁共振波谱和光谱成像的发展感兴趣。由于洛桑的预偏振器提供了大量的高度偏振材料，我们与洛桑团队建立了合作关系，在德克萨斯大学西南分校组装了一个偏振器。其目的是要有一个或多或少的交钥匙偏振器，用于活体研究。(梅里特博士设计的偏振器将用于偏振技术的研究，例如交叉偏振技术的开发。)这是一个推动生物医学项目，因为Comment博士的目的是在瑞士发展生物13C研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Drs. JJ van der Klink and A Comment have constructed and demonstrated pre-polarizers in their labs in Lausanne. The design is described in two recent papers, "A 140 GHz prepolarizer for dissolution dynamic nuclear polarization" J Chem Phys 2008; 128: 241102, and "Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP" J Magn Reson. 2008; 194: 152-5. This RR has a long-standing interest in the development of 13C NMR spectroscopy and spectroscopic imaging for clinical research. Since the Lausanne pre-polarizer offered high volumes of highly polarized materials, we established a collaboration with the Lausanne team to assemble a polarizer at UT Southwestern. The intent was to have a more-or-less turnkey polarizer available for in vivo studies. (The polarizer designed by Dr. Merritt will be used for research in the technology of polarization, such as the development of cross polarization techniques.) This is a Driving Biomedical Project because Dr. Comment's intent is to develop biological 13C studies in Switzerland.