ASSEMBLY OF A PRE-POLARIZER BASED ON A NARROW-BORE MAGNET

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 Drs. JJ货车der Klink和A Comment在他们位于洛桑的实验室中构建并演示了预偏振器。该设计在最近的两篇论文中进行了描述， “A 140 GHz prepolarizer for dissolution dynamic nuclear polarization”J Chem Phys 2008; 128：241102，和“Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP”J Magn Reson. 2008; 194：152-5. 该RR对13 C NMR光谱和光谱成像的临床研究发展有着长期的兴趣。 由于洛桑预偏振器提供了大量的高偏振材料，我们与洛桑团队建立了合作，在UT西南组装偏振器。 其目的是有一个或多或少交钥匙偏振器可用于体内研究。 (The Merritt博士设计的偏振器将用于偏振技术的研究，例如交叉偏振技术的开发。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Drs. JJ van der Klink and A Comment have constructed and demonstrated pre-polarizers in their labs in Lausanne. The design is described in two recent papers, "A 140 GHz prepolarizer for dissolution dynamic nuclear polarization" J Chem Phys 2008; 128: 241102, and "Producing over 100 ml of highly concentrated hyperpolarized solution by means of dissolution DNP" J Magn Reson. 2008; 194: 152-5. This RR has a long-standing interest in the development of 13C NMR spectroscopy and spectroscopic imaging for clinical research. Since the Lausanne pre-polarizer offered high volumes of highly polarized materials, we established a collaboration with the Lausanne team to assemble a polarizer at UT Southwestern. The intent was to have a more-or-less turnkey polarizer available for in vivo studies. (The polarizer designed by Dr. Merritt will be used for research in the technology of polarization, such as the development of cross polarization techniques.)