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Virology

病毒学

基本信息

批准号：
8340212
负责人：
NANCY JOAN RAAB-TRAUB
金额：
$ 17.79万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-23 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8340212
关键词：
AIDS related cancer AIDS-Related Lymphoma Accounting Acquired Immunodeficiency Syndrome Affect Alphavirus Animal Model Antiviral Agents Apoptosis Area Binding Biochemical Biological Models Cancer Center Cancer Etiology Cell Communication Cell Cycle Progression Cell physiology Central Nervous System Lymphoma Clinical Collaborations Complex DNA Damage Deubiquitination Developing Countries Development Dimerization Double-Stranded RNA Electrons Event Extramural Activities Faculty Funding Future Gene Delivery Genes Goals Grant Growth HIV Seropositivity Head Hepatitis C virus Herpesviridae Human Human Herpesvirus 4 Human Herpesvirus 8 Human Papillomavirus Human papilloma virus infection Imagery Immune response Immune system Immunity Immunocompromised Host Immunology Immunosuppression In Vitro Inflammation Institutes Intention Interferon Activation Interferons Kaposi Sarcoma Knowledge Link Location Malignant - descriptor Malignant Neoplasms Membrane Proteins MicroRNAs Microscopic Mind Modeling Modern Medicine Molecular Mus Mutation NF-kappa B National Cancer Institute Natural Immunity Nuclear Translocation Nucleic Acids Oncogene Proteins Oncogenic Viruses Oral Outcome Pathogenesis Pathology Pathway interactions Peripheral Phosphotransferases Population Process Program Research Project Grants Property Protein Kinase Protein p53 Proteins Proteomics Recruitment Activity Regulation Regulatory Pathway Research Research Peer Review Research Personnel Research Project Grants Resource Sharing Role SV40 T Antigens Sampling Signal Pathway Signal Transduction Simplexvirus Source Specimen System Technology Testing Therapeutic Toll-like receptors Transgenic Mice Ubiquitin Ubiquitination Vaccination Vaccines Viral Viral Cancer Viral Pathogenesis Viral Proteins Viral Vector Virus Virus Diseases Virus-Cell Membrane Interaction Xenograft procedure acquired immunity base cancer therapy cancer type cell growth cell transformation cervical and anal cancer cost gene therapy global health improved inhibitor/antagonist member mortality mouse model next generation novel novel vaccines pathogen prevent programs response sensor success therapy development translational study tumor tumorigenesis ubiquitin ligase vaccine development vector virology

项目摘要

Virology The goals of the Virology Program are to continue to identify the mechanisms through which human tumor viruses induce cancer and to use these findings to develop translational studies that target these processes. The major programmatic areas are Immunity, Pathogenesis, Vims:Cell Interactions, and AIDS-associated Cancers: A.) The Immunity group has focused on the development of effective new vaccines for viral infection and cancer, viral vectors for gene delivery, and the identification of the effects of viral infection on innate immunity and inflammation. Alphavimses and corona viruses have powerful effects on innate immunity and their mechanisms to impair this response are under study. Additionally, the effects of EBV and KSHV on interferon regulatory factors and toll-like receptors are under study. B.) The Pathogenesis group analyzes human tumor specimens to identify the viral effects on cell growth and expression and have developed transgenic mice to model the malignancies associated with these viruses. C.) The VimsiCell Interaction's studies have revealed effects of EBV and KSHV on the ubiquitin pathway including the identification of virally encoded deubiquitinases, and have analyzed viral activation of the PI3kinase/Akt/pcatenin and NFKB pathways. D.) The study of AIDS-associated virally induced cancers is expanding and three NCI supplemental grants for the study of AIDS-associated cancers have been recently funded. Experimental translational studies have been initiated to treat AIDS-associated lymphomas and characterize oral HPV infection. Three of the investigators that study human herpesvimses are funded through a Virology Program Project grant with projects that are based on newly developed technologies that are available through the Lineberger Cancer Center shared resources, including the Proteomics Core and Next Generation Sequencing. New members of the Program study viral infections in humanized mouse models, HCV, and human papilloma virus (HPV). The etiologic contributions of the human tumor viruses, EBV, KSH'V, HCV, and HPV will be further analyzed through the study of clinical samples, in vitro transformation systems, and animal models. The future plans for the Program include recruitment of additional investigators in virally-associated cancers and the expansion of specific anti-viral and immuno-therapies for these cancers with specific focus on experimental therapeutics for AIDS malignancies.

病毒学病毒学计划的目标是继续确定人类肿瘤病毒诱发癌症的机制，并利用这些发现开展针对这些过程的转化研究。主要规划领域是免疫、发病机制、病毒：细胞相互作用和艾滋病相关癌症：A.) 免疫小组重点开发用于病毒感染和癌症的有效新疫苗、用于基因传递的病毒载体，以及鉴定病毒感染对先天免疫和炎症的影响。甲病毒和冠状病毒对先天免疫具有强大的影响，其损害这种反应的机制正在研究中。此外，EBV 和 KSHV对干扰素调节因子和Toll样受体的影响正在研究中。 B.) 发病机制小组分析了人类肿瘤标本，以确定病毒对细胞生长和表达的影响，并开发了转基因小鼠来模拟与这些病毒相关的恶性肿瘤。 C.) VimsiCell Interaction 的研究揭示了 EBV 和 KSHV 对泛素通路的影响，包括病毒编码的去泛素酶的鉴定，并分析了 PI3kinase/Akt/pcatenin 和 NFKB 通路的病毒激活。 D.) 艾滋病相关病毒诱发癌症的研究正在扩大，最近国家癌症研究所为艾滋病相关癌症研究提供了三项补充拨款。实验性转化研究已经启动，用于治疗艾滋病相关淋巴瘤并确定口腔 HPV 感染的特征。研究人类疱疹病毒的三名研究人员通过病毒学计划项目拨款获得资助，这些项目基于新开发的技术，可通过 Lineberger 癌症中心共享资源获得，包括蛋白质组学核心和下一步世代测序。该计划的新成员研究人源化小鼠模型、HCV 和人乳头瘤病毒 (HPV) 中的病毒感染。通过临床样本、体外转化系统和动物模型的研究，将进一步分析人类肿瘤病毒、EBV、KSH'V、HCV 和 HPV 的病原学贡献。该计划的未来计划包括招募更多病毒相关癌症的研究人员以及针对这些癌症的特定抗病毒和免疫疗法的扩展，特别关注艾滋病恶性肿瘤的实验疗法。