Virology

病毒学

基本信息

批准号：
8340212
负责人：
NANCY JOAN RAAB-TRAUB
金额：
$ 17.79万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-05-23 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8340212
关键词：
AIDS related cancer AIDS-Related Lymphoma Accounting Acquired Immunodeficiency Syndrome Affect Alphavirus Animal Model Antiviral Agents Apoptosis Area Binding Biochemical Biological Models Cancer Center Cancer Etiology Cell Communication Cell Cycle Progression Cell physiology Central Nervous System Lymphoma Clinical Collaborations Complex DNA Damage Deubiquitination Developing Countries Development Dimerization Double-Stranded RNA Electrons Event Extramural Activities Faculty Funding Future Gene Delivery Genes Goals Grant Growth HIV Seropositivity Head Hepatitis C virus Herpesviridae Human Human Herpesvirus 4 Human Herpesvirus 8 Human Papillomavirus Human papilloma virus infection Imagery Immune response Immune system Immunity Immunocompromised Host Immunology Immunosuppression In Vitro Inflammation Institutes Intention Interferon Activation Interferons Kaposi Sarcoma Knowledge Link Location Malignant - descriptor Malignant Neoplasms Membrane Proteins MicroRNAs Microscopic Mind Modeling Modern Medicine Molecular Mus Mutation NF-kappa B National Cancer Institute Natural Immunity Nuclear Translocation Nucleic Acids Oncogene Proteins Oncogenic Viruses Oral Outcome Pathogenesis Pathology Pathway interactions Peripheral Phosphotransferases Population Process Program Research Project Grants Property Protein Kinase Protein p53 Proteins Proteomics Recruitment Activity Regulation Regulatory Pathway Research Research Peer Review Research Personnel Research Project Grants Resource Sharing Role SV40 T Antigens Sampling Signal Pathway Signal Transduction Simplexvirus Source Specimen System Technology Testing Therapeutic Toll-like receptors Transgenic Mice Ubiquitin Ubiquitination Vaccination Vaccines Viral Viral Cancer Viral Pathogenesis Viral Proteins Viral Vector Virus Virus Diseases Virus-Cell Membrane Interaction Xenograft procedure acquired immunity base cancer therapy cancer type cell growth cell transformation cervical and anal cancer cost gene therapy global health improved inhibitor/antagonist member mortality mouse model next generation novel novel vaccines pathogen prevent programs response sensor success therapy development translational study tumor tumorigenesis ubiquitin ligase vaccine development vector virology

项目摘要

Virology The goals of the Virology Program are to continue to identify the mechanisms through which human tumor viruses induce cancer and to use these findings to develop translational studies that target these processes. The major programmatic areas are Immunity, Pathogenesis, Vims:Cell Interactions, and AIDS-associated Cancers: A.) The Immunity group has focused on the development of effective new vaccines for viral infection and cancer, viral vectors for gene delivery, and the identification of the effects of viral infection on innate immunity and inflammation. Alphavimses and corona viruses have powerful effects on innate immunity and their mechanisms to impair this response are under study. Additionally, the effects of EBV and KSHV on interferon regulatory factors and toll-like receptors are under study. B.) The Pathogenesis group analyzes human tumor specimens to identify the viral effects on cell growth and expression and have developed transgenic mice to model the malignancies associated with these viruses. C.) The VimsiCell Interaction's studies have revealed effects of EBV and KSHV on the ubiquitin pathway including the identification of virally encoded deubiquitinases, and have analyzed viral activation of the PI3kinase/Akt/pcatenin and NFKB pathways. D.) The study of AIDS-associated virally induced cancers is expanding and three NCI supplemental grants for the study of AIDS-associated cancers have been recently funded. Experimental translational studies have been initiated to treat AIDS-associated lymphomas and characterize oral HPV infection. Three of the investigators that study human herpesvimses are funded through a Virology Program Project grant with projects that are based on newly developed technologies that are available through the Lineberger Cancer Center shared resources, including the Proteomics Core and Next Generation Sequencing. New members of the Program study viral infections in humanized mouse models, HCV, and human papilloma virus (HPV). The etiologic contributions of the human tumor viruses, EBV, KSH'V, HCV, and HPV will be further analyzed through the study of clinical samples, in vitro transformation systems, and animal models. The future plans for the Program include recruitment of additional investigators in virally-associated cancers and the expansion of specific anti-viral and immuno-therapies for these cancers with specific focus on experimental therapeutics for AIDS malignancies.

病毒学病毒学计划的目标是继续确定人类肿瘤病毒诱导癌症的机制，并使用这些发现来开发针对这些过程的转化研究。主要的程序化区域是免疫，发病机理，VIM：细胞相互作用和与艾滋病相关的癌症：A。）免疫组集中于开发有效的病毒感染和癌症的有效新疫苗，用于基因递送的病毒载体，以及病毒感染对先天免疫和炎症的影响。 Alphavimses和Corona病毒对先天免疫具有强大的影响及其损害这种反应的机制。此外，EBV和研究干扰素调节因子和Toll样受体的KSHV正在研究中。 B.）发病机构分析人类肿瘤标本，以鉴定病毒对细胞生长和表达的影响，并开发了转基因小鼠，以模拟与这些病毒相关的恶性肿瘤。 C.）Vimsicell相互作用的研究揭示了EBV和KSHV对泛素途径的影响，包括鉴定病毒编码的去泛素酶，并分析了PI3Kinase/akt/pcatenin和nfkb途径的病毒激活。 D.）最近对与艾滋病相关的病毒诱导癌症的研究正在扩大，最近已经资助了三项用于研究艾滋病相关癌症的NCI补充补助。已经开始了实验转化研究，以治疗与艾滋病相关的淋巴瘤并表征口服HPV感染。研究人疱疹的三名研究人员是通过病毒学计划项目赠款资助的，该项目基于新开发的技术，这些技术可通过Lineberger Cancer Center共享资源，包括蛋白质组学核心和下一步生成测序。该程序的新成员研究了人源性小鼠模型，HCV和人乳头瘤病毒（HPV）中的病毒感染。通过研究临床样品，体外转化系统和动物模型，将进一步分析人类肿瘤病毒，EBV，KSH'V，HCV和HPV的病因贡献。该计划的未来计划包括招募其他病毒相关癌症的研究者以及这些癌症的特定抗病毒和免疫治疗的扩展，特别关注艾滋病恶性肿瘤的实验疗法。