Neuroimaging Core (Page 433)

神经影像学核心的总体目标是为HNRC和合作研究者提供 1）使用广泛的技术在体内检测HIV相关脑损伤，包括 结构、功能、代谢、磁化率和弥散加权MRI以及正电子发射 断层扫描（PET）; 2）尸检MR成像，用于阐明引起 这种损害; 3）这些成像的认知后果和神经医学相关性的调查 效果;和4）鉴定治疗成功的潜在生物标志物。在本资助期内， 核心已经支持了30多个项目，例如，结果将可检测的CSF HIV 基线时的病毒载量，随着时间的推移，白色物质损伤增加;结构、扩散和 白色物质损伤的组织病理学证据;白色物质束扩散率降低与 认知障碍;以及HIV相关的晶状体区脑血流量减少。培训和 为31人提供了咨询，从而为艾滋病毒研究招募了新的调查人员， 扩大神经成像技术在国家和国际环境中的使用。额外 合作推进了我们的目标，以扩大有效的神经成像方法的范围， 用于艾滋病研究。在建议的续期期间，我们的目标是：a）提供资源、咨询，以及 神经成像技术援助; B）获取和分析体内和死后图像，以支持 临床解剖工作和试点研究; c）为开发改进的 用于艾滋病毒的图像采集和分析方法;以及d）教育研究界， 为神经艾滋病研究提供了新的成像方法。扩张的核心包括血管和PET 淀粉样蛋白成像，以推进对老龄化艾滋病毒人群的研究。此外，通过地方、国家和 国际合作，核心将强调方法验证和跨成像的数据集成 用于HIV的方式，可能导致更好地理解HIV对CNS影响的方法 感染这一核心将通过与联合国人权事务高级专员办事处密切合作， 神经行为学、神经医学、神经病毒学和神经生物学核心。这些广泛的功能 确保对HNRC相关研究的最新支持，与跨学科研究紧密结合， HNRC调查小组，并参与国家和国际神经影像学界。

The overall goal of the Neuroimaging Core is to provide the HNRC and collaborative investigators with resources for: 1) in vivo detection of HlV-related brain injury using a broad array of techniques, including structural, functional, metabolic, susceptibility and diffusion weighted MRI, and positron emission tomography (PET); 2) post-mortem MR imaging for elucidation of pathological mechanisms that give rise to this damage; 3) investigations of the cognitive consequences and neuromedical correlates of these imaging effects; and 4) identification of potential biomarkers for treatment success. In the current funding period, the Core has supported more than 30 projects, resulting in, for example, findings linking detectable CSF HIV viral load at baseline with increases in white matter damage over time; integration of structural, diffusion and histopathological evidence of white matter damage; correlation of reduced white matter tract diffusivity with cognitive impairment; and HIV-associated reductions in cerebral blood flow in lenticular regions. Training and consultation were provided for 31 individuals, resulting in recruiting new investigators to the study of HIV and expanding the use of neuroimaging techniques in national and international settings. Additional collaborations have advanced our goals to expand the range of valid neuroimaging methods available for use in HIV research. Our aims in the proposed renewal period are to: a) provide resources, consultation, and technical assistance for neuroimaging; b) acquire and analyze in vivo and postmortem images to support clinico-anatomic work and pilot studies; c) contribute data and expertise for the development of improved image acquisition and analytic methods for use in HIV; and d) educate research communities regarding promising new imaging approaches for neuroAIDS research. The expanded Core includes vascular and PET amyloid imaging, to advance the study of an aging HIV population. Furthermore, through local, national, and international collaborations, the Core will emphasize method validation and data integration across imaging modalities for use in HIV, approaches that may lead to a better understanding of the CNS effects of HIV infection. This Core will enhance HNRC transdisciplinary aims through close collaboration with the Neurobehavioral, Neuromedical, Neurovirology, and Neurobiology Cores. These broad-ranging functions ensure state of the art support for HNRC-associated studies, close integration with the interdisciplinary HNRC investigative team, and participation in national and international neuroimaging communities.