STRUCTURAL NEUROIMAGING CORE

结构神经影像核心

• 批准号: 8171126
• 负责人: TERRY L. JERNIGAN
• 金额: $ 0.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171126
• 关键词: Autopsy; Brain; Brain imaging; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Consultations; Data; Development; Diffusion; Disease; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Generations; Grant; HIV encephalitis; Image; Image Analysis; Institution; Laboratories; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Measurable; Mentorship; Methods; Modality; Monitor; Nature; Participant; Pilot Projects; Population; Research; Research Infrastructure; Research Personnel; Resources; Source; Structure; Students; Techniques; Training; Training Programs; United States National Institutes of Health; Work; brain morphology; brain tissue; in vivo; method development; neuroimaging; programs; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this Core are: 1) To assist in characterizing study participants, by providing information about gross brain morphology, with a particular emphasis on neuroanatomical abnormalities present late in the capabilities to studies requiring detailed regional neuroanatomic characterization; 3) To support, with consultation; 3) To support, with consultation and generation of sMRI data for pilot studies, new research initiatives employing neuroimaging techniques, such as MR Spectroscopy (MRS), MR diffusion imaging, and functional MRI (fMRI); 4) To provide a liaison between HNRC investigators and two associated neuroimaging programs: (a) the Brain Image Analysis Laboratory (BIAL), a (REAP), a multi-investigator core infrastructure and training program focusing on applications of fMRI in dementing disorders (T. Jernigan, P.I.); 5) To provide mentorship, consultation, and training in neuroimaging to students and junior investigators affiliated with the HNRC. The Core will support ongoing work investigating the nature and regional distribution of HIV-related brain abnormalities measurable in vivo (with sMRI data), as well as new work aimed at developing more sensitive and more efficient means of monitoring HIV-related CNS dysfunction with other neuroimaging modalities (e.g., fMRI, MR Spectroscopy, etc.). The Core will also focus on new method development targeting the specific abnormalities present in this population, including the development of: more fully automated image-analytic methods for assessment of brain structure from MRI volumes; maps of the distribution of brain tissue anomalies associated with CDC-C3 status and ultimately, with autopsy-verified HIV encephalitis (HIVE); and more sophisticated methods for characterizing prevalent MRI abnormalities in cerebral white matter.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本核心的主要目的是：1）通过提供关于大体脑形态的信息，特别强调在需要详细的区域神经解剖学表征的研究能力后期出现的神经解剖学异常，协助表征研究参与者; 3）通过咨询提供支持; 3）通过咨询和生成用于试点研究的sMRI数据，支持采用神经成像技术的新研究计划，例如MR光谱（MRS），MR扩散成像和功能MRI（fMRI）; 4）为HNRC研究者和两个相关的神经影像学项目提供联系：（a）脑图像分析实验室（BIAL），（a）REAP，一个多研究者核心基础设施和培训项目，专注于功能磁共振成像在痴呆症中的应用（T. Jernigan，P.I.）; 5)为HNRC的学生和初级研究人员提供神经影像学方面的指导、咨询和培训。该核心将支持正在进行的调查体内可测量的HIV相关脑异常的性质和区域分布的工作（使用sMRI数据），以及旨在开发更敏感和更有效的方法来监测HIV相关CNS功能障碍的新工作，这些方法与其他神经成像方式（例如，fMRI、MR光谱学等）。该核心还将侧重于针对这一人群中存在的特定异常开发新方法，包括开发：更全自动的图像分析方法，用于从MRI体积评估大脑结构;与CDC-C3状态相关的脑组织异常分布图，最终与尸检证实的艾滋病毒脑炎（HIVE）相关;以及更复杂的方法来表征大脑白色物质中普遍存在的MRI异常。