Sitagliptin therapy to improve outcomes after islet autotransplantation.

西他列汀治疗可改善胰岛自体移植后的结果。

• 批准号: 8325623
• 负责人: Melena D. Bellin
• 金额: $ 16.21万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8325623
• 关键词: Acute; Address; Adverse effects; Advisory Committees; Area; Autologous Transplantation; Award; Back; Beta Cell; Cell physiology; Characteristics; Childhood; Clinical; Clinical Research; Clinical Trials; Cohort Studies; Counseling; Data; Diabetes Mellitus; Diagnosis; Double-Blind Method; Endocrinology; Engraftment; Environment; Enzymes; Fibrosis; Foundations; Gender; Glucose; Goals; Harvest; Hospitalization; Immunology; Individual; Inflammation; Insulin; Insulin-Dependent Diabetes Mellitus; International; Intervention; Intravenous; Islets of Langerhans Transplantation; K-Series Research Career Programs; Knowledge; Manuscripts; Measures; Melena; Mentors; Metabolic; Minnesota; Modeling; Monitor; Mus; Narcotic Addiction; Narcotics; Office Visits; Operative Surgical Procedures; Oral; Outcome; Pain; Pancreatectomy; Pancreatitis; Patients; Peer Review; Placebos; Positioning Attribute; Procedures; Publications; Randomized; Randomized Clinical Trials; Research; Research Personnel; Research Project Grants; Series; Stimulus; Stress; Students; Testing; Time; Total Pancreatectomy; Training; Transplantation; Universities; allotransplant; analog; base; chronic pancreatitis; clinically significant; control trial; cost; diabetes risk; exenatide; experience; gastrointestinal; glucagon-like peptide 1; improved; incretin hormone; inhibitor/antagonist; insulin secretion; intravenous glucose tolerance test; islet; meetings; patient oriented research; pediatric department; prevent; professor; prognostic; programs; public health relevance; randomized placebo controlled trial; response; success; symposium

DESCRIPTION (provided by applicant): Melena Bellin, MD is an Assistant Professor in the Department of Pediatrics, Division of Pediatric Endocrinology, at the University of Minnesota (UM). In this position, she devotes 75% of her time to patient-oriented research in the field of islet transplantation. Specific goals during this career development award period will include: 1) improved knowledge in clinical trials management, immunology, and islet transplantation; 2) publication of 2 peer-reviewed manuscripts per year; 3) completion of a clinical trial as described below; and 4) submission of a R-series research grant in the last 2 years of this award. Dr. Bellin has had formal training in patient-oriented research as a student in the M.S. program in Clinical Research at UM. She has been a co-investigator in cohort studies and small non-randomized clinical trials in islet transplant. She will build upon this foundation during the career development award period through formal training in more specific areas related to her research, attendance at national and international conferences in her field, and by conducting a large randomized clinical trial. Under the guidance of Dr. Antoinette Moran, the project mentor, Dr. Bellin will conduct a randomized double-blinded controlled trial evaluating the effect of sitagliptin treatment following total pancreatectomy and islet autotransplant on insulin independence and islet function. This project will have two aims: 1) to determine if treatment with a DPP-4 inhibitor after total pancreatectomy and islet autotransplant increases the proportion of recipients achieving insulin independence, and 2) to evaluate whether preoperative tests of islet function correlate with islet yield. Although incretin-based therapies have been used in very small, non-randomized trials of islet allotransplantation, this will be the first large randomized study to investigate such a therapy in islet autotransplant. Research projects will be conducted under the guidance of a mentor and co-mentors experienced in the fields of diabetes and islet transplant research-- Dr. Antoinette Moran, Dr. Bernhard Hering, and Dr. David Sutherland. The extensive experience with islet transplants at UM makes this an ideal environment for this research focus. Overall scholarly progress will be monitored by regular meetings with an advisory committee. PUBLIC HEALTH RELEVANCE: Islet transplant is an emerging new treatment for chronic pancreatitis and type 1 diabetes mellitus. This project will explore patient characteristics and an intervention which may improve the success of islet transplant.

描述（由申请人提供）： Melena Bellin 医学博士是明尼苏达大学 (UM) 儿科内分泌科儿科助理教授。在这个职位上，她将 75% 的时间投入到胰岛移植领域以患者为导向的研究上。职业发展奖励期间的具体目标将包括：1）提高临床试验管理、免疫学和胰岛移植方面的知识； 2）每年发表2篇同行评审稿件； 3) 完成下述临床试验； 4) 在该奖项的最后两年内提交 R 系列研究资助。 贝林博士作为硕士学位的学生接受过以患者为导向的研究的正式培训。密歇根大学临床研究项目。她一直是胰岛移植队列研究和小型非随机临床试验的共同研究员。她将在职业发展奖励期间通过在与她的研究相关的更具体领域的正式培训、参加她所在领域的国内和国际会议以及进行大型随机临床试验来巩固这一基础。在项目导师Antoinette Moran博士的指导下，Bellin博士将进行一项随机双盲对照试验，评估全胰腺切除术和胰岛自体移植后西他列汀治疗对胰岛素独立性和胰岛功能的影响。该项目有两个目标：1) 确定全胰腺切除术和胰岛自体移植后使用 DPP-4 抑制剂治疗是否会增加受者实现胰岛素独立的比例，2) 评估术前胰岛功能测试是否与胰岛产量相关。尽管基于肠促胰素的疗法已用于胰岛同种异体移植的非常小型的非随机试验中，但这将是第一个在胰岛自体移植中研究此类疗法的大型随机研究。 研究项目将在糖尿病和胰岛移植研究领域经验丰富的导师和共同导师 Antoinette Moran 博士、Bernhard Hering 博士和 David Sutherland 博士的指导下进行。密歇根大学在胰岛移植方面的丰富经验使其成为该研究重点的理想环境。总体学术进展将通过与咨询委员会的定期会议进行监督。 公众健康相关性：胰岛移植是一种治疗慢性胰腺炎和 1 型糖尿病的新兴疗法。该项目将探讨患者特征和可能提高胰岛移植成功率的干预措施。