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Reading and the Right Fusiform

阅读和右纺锤形

基本信息

批准号：
8514950
负责人：
Julie A Fiez
金额：
$ 27.8万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2016-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Years of interdisciplinary research have significantly advanced our understanding of optimal methods for reading instruction, orthographic and phonological variables that interact with word identification, and the neural substrates that support reading. However, core theoretical issues remain unresolved. For instance, a specific region in the left fusiform cortex, termed the Visual Word Form Area (VWFA), has been strongly implicated in orthographic processing. Overall, the current findings suggest the region is a core - perhaps even obligatory -- part of the pathway by which the perceptual analysis of written words ultimately provides fluent access to representations of phonology and meaning. In this proposal, we consider an alternative possibility: namely, that the right fusiform cortex can provide an alternative route through which print can gain access to the language system. We will test this hypothesis by examining the effect of cultural (Aim 1), individual (Aim 2), and orthographic (Aim 3) differences on the magnitude, time course, and functional connectivity of the right and left fusiform cortex. We will relate fusiform activity to measures of reading skill, and to behavioral markers for different types of orthographic analysis. The results should inform the theoretical debate about the VWFA, and they may lead to new approaches for the treatment of acquired and developmental reading disorders. PUBLIC HEALTH RELEVANCE: The overarching goal of the proposed research is to determine whether the right fusiform can provide an alternative route into the language system, a possibility that is raised by our findings with native Chinese speakers. The answer will shed light on the ongoing debate about the nature of the Visual Word Form Area (VWFA) and the impact of perceptual analysis upon phonological coding during reading. Longer term, the answer may also have important clinical implications: if the right fusiform can support reading independently from the left fusiform (i.e., VWFA), then it may be possible to design new approaches to the treatment of individuals with acquired or developmental dysfunction of the VWFA.

描述（由申请人提供）：多年的跨学科研究极大地增进了我们对阅读教学的最佳方法、与单词识别相互作用的拼写和语音变量以及支持阅读的神经基质的理解。然而，核心理论问题仍未得到解决。例如，左侧梭状皮质中的一个特定区域，称为视觉词形区域（VWFA），与拼写处理密切相关。总体而言，目前的研究结果表明，该区域是对书面文字的感知分析最终提供对音系和意义表示的流畅访问的途径的核心（甚至可能是强制性的）部分。在这个提议中，我们考虑了另一种可能性：即，右侧梭状皮层可以提供另一种途径，通过该途径印刷可以访问语言系统。我们将通过检查文化（目标 1）、个体（目标 2）和拼写（目标 3）差异对左右梭状皮层的大小、时间进程和功能连接的影响来检验这一假设。我们将把梭形活动与阅读技能的测量以及不同类型的拼写分析的行为标记联系起来。研究结果将为有关 VWFA 的理论争论提供信息，并且可能会带来治疗获得性和发育性阅读障碍的新方法。公共健康相关性：拟议研究的总体目标是确定正确的梭形是否可以提供进入语言系统的替代途径，我们对中文母语者的研究结果提出了这种可能性。答案将揭示有关视觉词形区域（VWFA）的性质以及阅读过程中感知分析对语音编码的影响的持续争论。从长远来看，这个答案也可能具有重要的临床意义：如果右侧梭形能够支持独立于左侧梭形（即VWFA）的阅读，那么就有可能设计出新的方法来治疗患有VWFA获得性或发育性功能障碍的个体。