Mobile technology and online tools to track adherence in chronic illness patients

描述（由申请人提供）：在美国，目前每四个年轻人中就有一个患有慢性疾病，使年轻人能够掌握自己的医疗保健至关重要。研究表明，从儿科护理成功过渡到以成人为重点的卫生保健系统的一个关键组成部分是对治疗方案的适当管理[10]。不幸的是，患有慢性疾病的青少年患者的治疗依从性低得令人失望，所有患者中有50-70%的患者的治疗依从性较差。对依从性研究的回顾表明，随着疾病和治疗相关知识的增加，治疗不依从性的风险降低，提供行为管理成分可优化依从性[8-10]。第二阶段SBIR项目的目标是继续研究和开发在线医疗监测系统（OMMS），这是一个综合的在线和移动技术基础设施，专门用于(a)通过互动和基于游戏的教育材料提高青少年的疾病和治疗相关知识；(b)通过移动和基于网络的交付方式定制任务提示，支持对治疗方案的依从性；(c)通过真实世界的数据收集和同步反馈循环促进医患沟通。在第二阶段，我们将以第一阶段的反馈为基础，最终确定功能齐全的产品，并进行实地测试，检查OMMS提高患有各种慢性疾病的青少年治疗依从性的程度。该二期项目将实现三个具体目标：1)全面开发OMMS产品；2)对患有慢性疾病的青少年进行OMMS益处的实地测试；3)完成OMMS并为大规模商业化做好准备。据我们所知，OMMS将是第一个将教育、依从性跟踪和患者-提供者沟通工具集成到一个综合、简化的软件包中的技术产品。我们期望OMMS能够有效地为患有慢性疾病的青年提供必要的信息和急需的支持，帮助他们成功地协商治疗方案，并过渡到自我管理的医疗保健。

DESCRIPTION (provided by applicant): With one out of every four youth in the United States currently living with a chronic illness, it is critically important to empower youth to take ownersip of their own healthcare. Research suggests that a key component of a successful transition from pediatric care into adult-focused health care systems is proper management of treatment regimens [1]. Unfortunately, treatment adherence among adolescents with chronic illness is disappointingly low, with poor adherence found in 50-70% of all patients [2]. Reviews of adherence studies indicate the risk of treatment nonadherence declines with greater disease- and treatment-related knowledge and that providing a behavioral management component optimizes adherence [8-10]. The goal of this Phase II SBIR project is to continue the research and development of the Online Medical Monitoring System (OMMS), an integrated online and mobile technology infrastructure specifically designed to (a) enhance youths' disease- and treatment-related knowledge through interactive and game-based educational materials; (b) support adherence to the treatment regimen through customized task prompts via mobile and web-based delivery; and (c) promote patient-provider communication through real-world data collection and synchronized feedback loops. During Phase II, we will build on Phase I feedback to finalize the fully functioning product and conduct a field test examining the degree to which the OMMS enhances treatment adherence outcomes among adolescents with a variety of chronic illnesses. This Phase II project will accomplish three specific aims: 1) fully develop the OMMS product; 2) conduct a field test of the benefits of the OMMS with adolescents with chronic illness; and 3) finalize the OMMS and ready for broad scale commercialization. To our knowledge, the OMMS will be the first technology product that integrates educational, adherence tracking, and patient-provider communication tools into one comprehensive, streamlined package. We expect the OMMS to effectively provide essential information and much needed support to youth with chronic illness to help them successfully negotiate their treatment regimen and transition into self-managed healthcare.