The Influence of Gender on Symptom Characteristics During Acute Coronary Syndrome

性别对急性冠脉综合征症状特征的影响

• 批准号: 8660751
• 负责人: HOLLI A DEVON
• 金额: $ 9.99万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-28 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8660751
• 关键词: Accident and Emergency department; Address; Admission activity; Age; American; Back Pain; Biological Markers; Cardiovascular system; Caring; Characteristics; Clinical; Cluster Analysis; Comorbidity; Data; Data Collection; Diagnosis; Diagnostic tests; Distress; Dyspepsia; Evaluation; Event; Gender; Health; Health Care Seeking Behavior; Heart Diseases; Heart failure; Hospitals; Illinois; Incidence; Inflammation; Interleukin-18; Interleukin-6; Life; Longitudinal Studies; Measures; Medical Records; Medical center; Methods; Myocardial Infarction; Myocardial Ischemia; Nausea; Oregon; Outcome; Participant; Patients; Pattern; Predictive Value; Procedures; Prospective Studies; Recording of previous events; Recruitment Activity; Reporting; Research; Risk; Risk Factors; Sampling; Sensitivity and Specificity; Severities; Sex Characteristics; Shortness of Breath; Specificity; Stratification; Stroke; Symptoms; Testing; Triage; Tumor Necrosis Factor-alpha; Unstable angina; Variant; Visit; Woman; abstracting; acute coronary syndrome; care seeking; clinically significant; design; experience; functional status; men; mortality; novel strategies; prospective

Abstract More than 1.4 million Americans are expected to experience an episode of acute coronary syndromes (ACS) in 2010. Evaluation of the symptoms of ACS is important since symptoms determine when, or if, patients seek care. Recent studies have identified gender differences in symptoms of ACS, however retrospective designs, abstraction of symptoms from medical records, and variations in assessment forms make it difficult to determine the clinical significance of gender differences or if gender specific health messages are warranted. Therefore, the aims of this prospective study are to: 1) evaluate for gender differences in the occurrence, severity, and distress of 13 ACS symptoms after adjusting for age, diagnosis, comorbidities, and functional status, 2) establish the sensitivity, specificity, and predictive value of symptoms as an indicator of ACS for women and men, 3) explore symptom clusters including characteristics of gender, age, diagnosis, comorbidities, and functional status, and 4) determine if there are gender differences in the longitudinal (30 days and 6 months) outcomes of functional status, major cardiovascular events, hospital admissions, emergency department visits, and mortality. An exploratory aim is to determine if a relationship exists between selected biomarkers and symptoms of ACS for women and men. A novel approach, in which symptoms are recorded in the emergency department as they are occurring, will be used. The sample will be comprised of 630 patients admitted to the emergency department with symptoms suggestive of ACS: 522 patients with confirmed ACS and 108 patients ruled out for ACS. Participants will be recruited from four medical centers in Illinois and Oregon. The 13-item ACS Symptom Checklist will be completed on presentation to the emergency department. Comorbidities, activity status, and patient variables will be measured when the patient is stable. Pilot data indicate that the procedures are feasible and safe. Analysis of covariance will be used to test the hypothesis that there are gender differences in symptoms. Symptom clusters will be examined using agglomerative cluster analysis, and patient outcomes will be evaluated using linear mixed methods. Findings will aid in establishing the clinical significance of ACS symptoms.

摘要

项目成果

A Systematic Review of the Effects of Body Temperature on Outcome After Adult Traumatic Brain Injury.

• DOI: 10.1097/jnn.0000000000000142
• 发表时间: 2015-08
• 期刊: The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
• 作者: Madden LK;DeVon HA
• 通讯作者: DeVon HA

Takotsubo cardiomyopathy: an acute and reversible cardiomyopathy mimicking acute myocardial infarction.

Takotsubo 心肌病：一种类似于急性心肌梗塞的急性可逆性心肌病。

• 发表时间: 2008
• 期刊: Cardiovascular journal of Africa
• 影响因子: 0.7
• 作者: Middlemost,Shirley;Mabin,Thomas
• 通讯作者: Mabin,Thomas

Impact of comorbidities by age on symptom presentation for suspected acute coronary syndromes in the emergency department.

• DOI: 10.1177/1474515117693891
• 发表时间: 2017-08
• 期刊: European journal of cardiovascular nursing
• 影响因子: 2.9
• 作者: Burke LA;Rosenfeld AG;Daya MR;Vuckovic KM;Zegre-Hemsey JK;Felix Diaz M;Tosta Daiube Santos J;Mirzaei S;DeVon HA
• 通讯作者: DeVon HA

Cardiac symptoms in women and men.

女性和男性的心脏症状。

• DOI: 10.1001/jamainternmed.2013.9779
• 发表时间: 2013
• 期刊: JAMA internal medicine
• 影响因子: 39
• 作者: DeVon,HolliA;Rosenfeld,Anne;Daya,Mohamud
• 通讯作者: Daya,Mohamud

20 things you didn't know about women and heart disease.

关于女性和心脏病你不知道的 20 件事。

• DOI: 10.1097/jcn.0000000000000129
• 发表时间: 2014
• 期刊: The Journal of cardiovascular nursing
• 作者: DeVon,HolliA;Noureddine,Samar
• 通讯作者: Noureddine,Samar