Device to mechanically interrogate tissue and skin across research environments

在研究环境中机械询问组织和皮肤的设备

• 批准号: 8681920
• 负责人: Qi Wang
• 金额: $ 14.84万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8681920
• 关键词: Device; mechanically; interrogate; tissue; skin

Device to mechanically interrogate tissue and skin across research environments Relative changes in the tissue's response to mechanical deformation have been used for centuries to diagnose and classify diseases and often serve as surrogates for assessment of disease stage or progression. Pathological conditions such as arterial, venous, diabetic, lymphatic and collagen vascular disease are manifested in macroscopic and microscopic structural changes in the skin and soft tissues. Many devices have been designed to measure and describe the mechanical properties of skin in vivo and some devices have attained success in certain research environments. However, a remaining need exists for a device that is compatible with both lab-based and clinically-based research. Current device have not been proven useful for both types of research environments. In this project, we will develop a low-cost, portable technology, the mechanical interrogation of tissue and skin device (MITS), to quickly and accurately quantify the mechanical properties of the tissue and skin within a variety of healthcare research settings. Because skin and tissue research spans a wide range of clinical conditions, in this project we must focus on a few examples in order to develop MITS for versatile and wide ranging applications. Specifically, we will 1) Engineer the MITS hardware and software for multiple research applications and environments, 2) Model and optimize MITS performance using tissue phantoms, 3) Optimize MITS for use in animal (wound) and human (pressure ulcer and edematous limb) research utilizing an iterative design approach. The novelty of the MITS device is its small form factor, small area of interrogation, high bandwidth, and its readiness to utilize variable excitation patterns. While this project is focused on developing a versatile research instrument, the simplicity and small form factor of the MITS can form the basis for the development of a clinical diagnostic device. Since a design objective includes utility in a variety of clinical research environments, one can envision later development work to focus on clinical applications. The potential of having a clinical tool based upon the same technical principles of a research instrument would streamline the translation of research findings into clinical applications.

在研究环境中机械询问组织和皮肤的器械 几个世纪以来，组织对机械变形的反应的相对变化一直被用来诊断 并且对疾病进行分类，并且通常用作评估疾病阶段或进展的替代物。 病理状况，如动脉、静脉、糖尿病、淋巴和胶原血管疾病， 表现为皮肤和软组织的宏观和微观结构变化。许多器件具有 被设计用于测量和描述体内皮肤的机械特性， 在某些研究环境中取得了成功。然而，仍然需要一种 与基于实验室和临床的研究兼容。目前的设备还没有被证明是有用的， 这两种研究环境。 在这个项目中，我们将开发一种低成本，便携式技术，组织的机械询问， 皮肤装置（MITS），以快速和准确地量化组织和皮肤内的机械特性。 各种医疗保健研究环境。由于皮肤和组织研究涉及广泛的临床领域， 条件下，在这个项目中，我们必须集中在几个例子，以发展MITS的多功能和广泛的 范围应用。具体来说，我们将1）设计MITS硬件和软件，用于多项研究 应用程序和环境，2）使用组织模型建模和优化MITS性能，3）优化 MITS用于动物（伤口）和人类（压疮和水肿肢体）研究，采用迭代 设计方法MITS设备的新奇在于其小形状因子、小询问面积、高性能、低成本、高可靠性和高可靠性。 带宽，以及其利用可变激励模式的准备程度。虽然这个项目的重点是发展 作为一种多功能的研究仪器，MITS的简单性和小外形因素可以构成 开发临床诊断设备。由于设计目标包括在各种临床应用中的实用性， 研究环境中，可以设想以后的开发工作，以专注于临床应用。的 具有基于研究仪器的相同技术原理的临床工具的潜力将 简化将研究成果转化为临床应用的程序。