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Device to mechanically interrogate tissue and skin across research environments

在研究环境中机械询问组织和皮肤的设备

基本信息

批准号：
8515408
负责人：
Qi Wang
金额：
$ 16.78万
依托单位：
COLUMBIA UNIV NEW YORK MORNINGSIDE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-15 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8515408
关键词：
Animal Experimentation Animal Model Animals Applied Research Area Biopsy Clinic Clinical Clinical Research Collagen Computer software Contusions Decubitus ulcer Development Devices Diagnosis Diagnostic Disease Edema Elastomers Engineering Environment Health Services Research Healthcare Home visitation House Call Human Image Isometric Exercise Isotonic Exercise Limb structure Lower Extremity Lymphatic Manuals Measurement Measures Mechanics Methods Microscopic Modeling Necrosis Output Palpation Pathology Pattern Performance Positioning Attribute Property Rattus Readiness Relative (related person)Reporting Research Research Personnel Skin Skin Tissue Staging Techniques Technology Testing Tissues Translational Research Vascular Diseases Venous Work base clinical application cost design diabetic in vivo innovation instrument iterative design meetings response soft tissue success tissue phantom tool usability wound

项目摘要

DESCRIPTION (provided by applicant): Device to mechanically interrogate tissue and skin across research environments Relative changes in the tissue's response to mechanical deformation have been used for centuries to diagnose and classify diseases and often serve as surrogates for assessment of disease stage or progression. Pathological conditions such as arterial, venous, diabetic, lymphatic and collagen vascular disease are manifested in macroscopic and microscopic structural changes in the skin and soft tissues. Many devices have been designed to measure and describe the mechanical properties of skin in vivo and some devices have attained success in certain research environments. However, a remaining need exists for a device that is compatible with both lab-based and clinically-based research. Current device have not been proven useful for both types of research environments. In this project, we will develop a low-cost, portable technology, the mechanical interrogation of tissue and skin device (MITS), to quickly and accurately quantify the mechanical properties of the tissue and skin within a variety of healthcare research settings. Because skin and tissue research spans a wide range of clinical conditions, in this project we must focus on a few examples in order to develop MITS for versatile and wide ranging applications. Specifically, we will 1) Engineer the MITS hardware and software for multiple research applications and environments, 2) Model and optimize MITS performance using tissue phantoms, 3) Optimize MITS for use in animal (wound) and human (pressure ulcer and edematous limb) research utilizing an iterative design approach. The novelty of the MITS device is its small form factor, small area of interrogation, high bandwidth, and its readiness to utilize variable excitation patterns. While this project is focused on developing a versatile research instrument, the simplicity and small form factor of the MITS can form the basis for the development of a clinical diagnostic device. Since a design objective includes utility in a variety of clinical research environments, one can envision later development work to focus on clinical applications. The potential of having a clinical tool based upon the same technical principles of a research instrument would streamline the translation of research findings into clinical applications.

描述（由申请人提供）：用于在研究环境中机械询问组织和皮肤的器械几个世纪以来，组织对机械变形的反应的相对变化一直用于诊断和分类疾病，并且通常用作评估疾病阶段或进展的替代物。病理状况如动脉、静脉、糖尿病、淋巴和胶原血管疾病表现为皮肤和软组织的宏观和微观结构变化。许多设备已被设计用于测量和描述皮肤在体内的机械性能，并且一些设备在某些研究环境中取得了成功。然而，仍然需要一种与实验室和临床研究兼容的设备。目前的设备尚未被证明对这两种类型的研究环境都有用。在这个项目中，我们将开发一种低成本，便携式技术，组织和皮肤设备（MITS）的机械询问，以快速，准确地量化各种医疗保健研究环境中的组织和皮肤的机械特性。由于皮肤和组织研究涵盖了广泛的临床条件，在这个项目中，我们必须集中在几个例子，以开发MITS的多功能和广泛的应用。具体而言，我们将1）针对多种研究应用和环境设计MITS硬件和软件，2）使用组织模型建模和优化MITS性能，3）使用迭代设计方法优化MITS用于动物（伤口）和人类（压疮和水肿肢体）研究。MITS装置的新奇在于其小形状因子、小询问面积、高带宽以及其易于利用可变激励模式。虽然该项目的重点是开发一种多功能的研究仪器，但MITS的简单性和小尺寸可以为临床诊断设备的开发奠定基础。由于设计目标包括在各种临床研究环境中的实用性，因此可以设想后期开发工作将重点放在临床应用上。具有基于研究仪器的相同技术原理的临床工具的潜力将简化将研究结果转化为临床应用的过程。