ANIMAL CORE

动物核心

• 批准号: 7714587
• 负责人: JORGE Pablo FIGUEROA
• 金额: $ 25.48万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7714587
• 关键词: Acute; Adult; Anesthesia procedures; Animal Model; Animals; Autopsy; Betamethasone; Chronic; Condition; Data; Databases; Date/Time; Endocrinology; Ensure; Gays; Gender; Goals; In Vitro; Individual; Injection of therapeutic agent; Knowledge; Laboratory Research; Measurement; Measures; Messenger RNA; Modeling; Numbers; Operative Surgical Procedures; Patient currently pregnant; Perinatal; Physiologic Monitoring; Physiological; Physiology; Plasma; Pregnancy; Preparation; Protocols documentation; Publications; Randomized; Rate; Research; Research Personnel; Research Project Grants; Sample Size; Sampling; Sheep; Stress; Tissue Banks; Tissues; Universities; Work; base; day; experience; fetal; forest; in vivo; instrument; medical schools; protein expression; research study; success; time use

(1) Objective The Animal Core will provide the investigators with chronically instrumented pregnant and nonpregnant sheep and with non instrumented pregnant and nonpregnant animals. The specific goals of the Animal Core are: (a) to obtain time-dated pregnant animals at 75 days of gestation. These animals will be randomly assigned to receive either vehicle or betamethasone injections at 80 an 81 gays gestation, (b) to prepare chronically instrumented adult or fetal sheep for use in the different research projects, (c) to conduct necropsies and facilitate the collection of tissues for the in vitro studies described in the individual projects, (d) to facilitate the in vivo studies involving monitoring physiologic variables in fetal, pregnant and nonpregnant sheep under acute or chronic conditions.

(1)目的 动物中心将为研究者提供长期内固定的妊娠和非妊娠动物 绵羊和未使用仪器的妊娠和非妊娠动物。动物核心的具体目标是： (a)获得妊娠75天的妊娠动物。这些动物将被随机分配至 在妊娠80和81周时接受载体或倍他米松注射，（B）以长期准备 （c）进行尸检，并促进 为各个项目中所述的体外研究收集组织，（d）促进体内 涉及监测胎儿、妊娠和非妊娠绵羊在急性或慢性条件下生理变量的研究 条件