University of Kansas Training Grant in Nephrology

描述（由申请人提供）：该计划认识到对高技能医学博士的持续需求。和博士研究人员解决慢性肾脏疾病的迅速发展对我们国家的冲击，旨在通过每年容纳两名博士后研究员进行肾脏研究方法和项目的强化培训来解决这一需求，国际公认的和NIH资助的导师在高度综合的跨学科环境中工作。研究培训持续2-3年。医学博士研究培训与一年的临床培训相结合，在临床医生导师的指导下，他们使用定量推理和实验室方法来解决肾脏疾病造成的医疗问题，以确保获得肾脏病委员会认证的资格。目前的研究领域包括人类肾脏疾病的分子遗传学和发病机制，最新的受体和信号转导生物化学，肾脏发育生物学，代谢性骨病的分子决定因素，肾脏疾病和高血压的临床决策分析和结果研究，上皮转运和代谢。成功完成奖学金后，学员将准备接受医学和/或基础科学学术部门或研究所的职位，在那里他们可以从事独立的研究事业。 公共卫生相关性：在美国，肾脏疾病每年在医疗保健支出中占1000亿美元以上。由于致力于寻找解决方案的训练有素的临床医生和基础科学家人数不足，目前在预防或减轻这一巨大问题方面几乎没有采取任何措施。这项研究培训计划是解决患有各种肾脏疾病的公民的医疗保健需求的重要一步。

DESCRIPTION (provided by applicant): This program recognizes the continuing need for highly skilled M.D. and Ph.D. researchers to address the burgeoning onslaught of chronic renal diseases descending on our Nation and is designed to address that need by accommodating two post-doctoral fellows each year for intensive training in renal research methods and projects with internationally recognized and NIH-funded mentors working in a highly integrated interdisciplinary environment. Research training lasts 2-3 years. For M.D. trainees, research training is interfaced with a year of clinical training, under the guidance of master clinician preceptors who use quantitative reasoning and laboratory methods to solve medical problems created by renal disease, to insure eligibility for Nephrology Board certification. Current researc areas include the molecular genetics and pathogenesis of human renal diseases, state-of-the-art receptor and signal transduction biochemistry, the biology of kidney developmental, molecular determinants of metabolic bone disease, clinical decision analysis and outcomes research for kidney diseases and hypertension, and epithelial transport and metabolism. Upon successful completion of the fellowship, the trainees will be prepared to accept positions in academic departments or institutes of medicine and/or basic science where they can pursue independent research careers. PUBLIC HEALTH RELEVANCE: Diseases of the kidney account for over 100 billion dollars in health care expenditure each year in the USA. Little is being done currently to prevent or mitigate this enormous problem owing to insufficient numbers of highly trained clinician and basic scientists committed to finding solutions. This research training program is an important step for addressing the health care needs of citizens with a broad array of kidney diseases.