ShEEP Request for Comprehensive Lab Animal Monitoring System (CLAMS) / Oxy CLAMS

ShEEP 请求综合实验动物监测系统 (CLAMS) / Oxy CLAMS

• 批准号: 9795636
• 负责人: H. Kirk Hammond
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795636
• 关键词: Address; Aerobic; American; Amputation; Animals; Behavioral; Biochemical; Bioenergetics; Biological; Blindness; Calorimetry; Carbon Dioxide; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Circadian Rhythms; Color; Computer software; Data; Data Collection; Data Files; Data Quality; Data Set; Detection; Diabetes Mellitus; Disease; Eating; Elements; End stage renal failure; Exercise; Food; Food Access; Gastroenterology; Goals; Graph; Head; Health; Healthcare Systems; Kidney Diseases; Laboratory Animals; Light; Lung; Magnetism; Measurement; Medical; Metabolic; Metabolic Diseases; Monitor; Names; Nephrology; Neurology; Neuropathy; Neurosciences; Organ; Organism; Oxygen; Paper; Pathologic; Patients; Pharmacologic Substance; Population; Publishing; Research; Research Personnel; Resistance; Risk; Rodent; Running; Sampling; Scheme; Scientist; Sheep; Side; Sleep; Statistical Data Interpretation; System; Temperature; Testing; Time; Travel; Urology; Veterans; Water consumption; Work; base; burden of illness; cost efficient; data sharing; disorder prevention; effective therapy; feeding; instrument; interest; metabolic abnormality assessment; novel; novel therapeutics; patient population; preclinical study; programs; screening; software systems; virtual

The Comprehensive Laboratory Animal Monitoring System (CLAMS) is used in many pre-clinical studies. This non-invasive metabolic monitoring system is of particular interest to researchers concerned with metabolic problems, because the relationship between inspired oxygen and expired carbon dioxide sets the biochemical limit of the organism. The requested system is equipped with 16 rodent stations, generally enough to perform two side-by-side group measurements for statistical analyses that also negates temporal variability. The system also has several secondary functions such as; 1) food and water intakes, 2) three coordinates activity, 3) automated food access, 4) sleep detection, 5) running wheels, and 6) temperature and light control. All these features would make this system a necessary part of our goal to produce high quality data in a time and cost efficient manner. The functionality of this system will allow a large and prolific group of VA San Diego Healthcare System (VASDHS) cardiovascular investigators (Drs. Hammond, Roth, and Patel) as well as our colleagues in the nephrology department (Drs. Vallon and Rajasekaran) and in neuroscience (Tuszynski, Risbrough, and Head) the opportunity to expand their experimental capabilities dramatically.

综合实验动物监测系统(CLAMS)在许多临床前应用 学习。这种非侵入性的代谢监测系统引起了研究人员的特别兴趣 关注代谢问题，因为吸氧量和呼气量之间的关系 二氧化碳设定了生物体的生化极限。所要求的系统配备了16个 啮齿动物站，通常足以进行两个并排的群体测量以进行统计 也否定了时间变异性的分析。该系统还具有几个辅助功能 例如：1)食物和水摄入量，2)三协调活动，3)自动食物获取，4)睡眠 检测，5)转轮，6)温度和灯光控制。所有这些功能将使这一点 该系统是我们以及时和经济高效的方式产生高质量数据的目标的必要组成部分。 该系统的功能将允许一个庞大而多产的VA San Diego Healthcare小组 系统(VASDHS)心血管研究人员(哈蒙德、罗斯和帕特尔博士)以及我们的 肾内科(Vallon和Rajasekaran博士)和神经科学的同事 (图辛斯基、里斯布罗和海德)有机会扩大他们的实验能力 戏剧性的。