ShEEP Request for a multi-array electrochemiluminescence biomarker assay reader

ShEEP 请求多阵列电化学发光生物标志物测定读取器

• 批准号: 9796660
• 负责人: Tammy Angaline Butterick
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796660
• 关键词: Alzheimer' s Disease; Antibodies; Award; Biological; Biological Assay; Biological Markers; Canis familiaris; Cardiovascular Diseases; Cardiovascular system; Cells; Charge; Collection; Computer software; Computers; Coupled; Couples; Data; Data Analyses; Databases; Department of Defense; Detection; Development; Devices; Diagnosis; Diagnostic Procedure; Dimensions; Disease; Electricity; Electrodes; Ensure; Equipment; Family suidae; Feces; Foundations; Funding; Gulf War; Health; Health Care Research; Healthcare; Healthcare Systems; Human; Human Resources; Immunoassay; Immunology; Label; Left; Light; Lung diseases; Malignant Neoplasms; Manufacturer Name; Maryland; Measurement; Measures; Metabolic Diseases; Minor; Modeling; Mus; Nerve Degeneration; Neurosciences; Obesity; Operating System; Oryctolagus cuniculus; Output; Peptides; Plasma; Privatization; Proteins; Provider; Pulmonology; Rattus; Reaction; Reader; Reporting; Research; Research Personnel; Resolution; Running; Sampling; Serum; Sheep; Side; Signal Pathway; Signal Transduction; Spottings; System; Technology; Tissues; Toxicology; Tube; United States; United States National Institutes of Health; Urine; Veterans; Weight; Whole Blood; base; biomarker discovery; biomarker identification; charge coupled device camera; chemical reaction; chemokine; cytokine; design; education research; experience; experimental study; instrument; lens; nonhuman primate; oncology; programs; service providers; targeted treatment

We are requesting the purchase of a multi-array electrochemiluminescence biomarker assay reader (MSD- MESO SECTOR S 600), manufactured by Meso Scale Discovery (MSD; Rockville, Maryland, USA). This system that provides highly sensitive measurements of molecules in biological samples from mouse, rat, porcine, rabbit, canine, non-human primate, and human, including but not limited to whole blood, serum, plasma, urine, feces, cell or tissue lysates. Biomarkers are assayed in a multiplex format. The underlying technology couples electrochemiluminescent technology and immunobioassay arrays for highly sensitive detection of proteins or peptides for the identification of biomarkers. The requested device will support 6 Major Users with VA funding (I01 BX004146, I01 BX003282, I01 BX003004, I01 BX 003687, I01 BX000760, IK2 BX003838, IK2 CX001095, VA CSP 588, VA NCI NAVIGATE). Identified major users are listed in Key Personnel. In addition to the VA projects supported by the requested equipment, Major and Minor Users benefitting from the acquisition are funded by NIH Awards (R01 DK054921, R01 DK100281, R01 NS108686, R01 NS092093, R01 NS086074, NIH “All Of Us” Program), Department of Defense awards (DOD CA150262, W81XWH), private foundation (Alzheimer’s Association AARGD-17-50549) and 5 awards administered by the Center for Veterans Research & Education (CVRE), our VA-affiliated nonprofit.

我们请求购买多阵列电化学发光生物标志物测定读取器（MSD- MESO SECTOR S 600)，由 Meso Scale Discovery（MSD；美国马里兰州罗克维尔）制造。这个系统 提供对小鼠、大鼠、猪、兔、 犬科动物、非人灵长类动物和人类，包括但不限于全血、血清、血浆、尿液、粪便、 细胞或组织裂解物。生物标志物以多重形式进行测定。底层技术结合在一起 电化学发光技术和免疫生物测定阵列，用于高灵敏度检测蛋白质或 用于鉴定生物标志物的肽。 所请求的设备将通过 VA 资金支持 6 个主要用户（I01 BX004146、I01 BX003282、I01 BX003004、 I01 BX 003687、I01 BX000760、IK2 BX003838、IK2 CX001095、VA CSP 588、VA NCI NAVIGATE）。已鉴定 主要用户列在关键人员中。 除了所需设备支持的 VA 项目外，主要和次要用户还受益于 此次收购由 NIH 奖项资助（R01 DK054921、R01 DK100281、R01 NS108686、R01 NS092093、 R01 NS086074，NIH“我们所有人”计划），国防部奖（DOD CA150262，W81XWH），私人 基金会（阿尔茨海默病协会 AARGD-17-50549）和退伍军人中心管理的 5 个奖项 研究与教育 (CVRE)，我们的 VA 附属非营利组织。