ShEEP Request for a multi-array electrochemiluminescence biomarker assay reader

ShEEP 请求多阵列电化学发光生物标志物测定读取器

• 批准号: 9796660
• 负责人: Tammy Angaline Butterick
• 金额: --
• 依托单位: MINNEAPOLIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796660
• 关键词: Alzheimer' s Disease; Antibodies; Award; Biological; Biological Assay; Biological Markers; Canis familiaris; Cardiovascular Diseases; Cardiovascular system; Cells; Charge; Collection; Computer software; Computers; Coupled; Couples; Data; Data Analyses; Databases; Department of Defense; Detection; Development; Devices; Diagnosis; Diagnostic Procedure; Dimensions; Disease; Electricity; Electrodes; Ensure; Equipment; Family suidae; Feces; Foundations; Funding; Gulf War; Health; Health Care Research; Healthcare; Healthcare Systems; Human; Human Resources; Immunoassay; Immunology; Label; Left; Light; Lung diseases; Malignant Neoplasms; Manufacturer Name; Maryland; Measurement; Measures; Metabolic Diseases; Minor; Modeling; Mus; Nerve Degeneration; Neurosciences; Obesity; Operating System; Oryctolagus cuniculus; Output; Peptides; Plasma; Privatization; Proteins; Provider; Pulmonology; Rattus; Reaction; Reader; Reporting; Research; Research Personnel; Resolution; Running; Sampling; Serum; Sheep; Side; Signal Pathway; Signal Transduction; Spottings; System; Technology; Tissues; Toxicology; Tube; United States; United States National Institutes of Health; Urine; Veterans; Weight; Whole Blood; base; biomarker discovery; biomarker identification; charge coupled device camera; chemical reaction; chemokine; cytokine; design; education research; experience; experimental study; instrument; lens; nonhuman primate; oncology; programs; service providers; targeted treatment

We are requesting the purchase of a multi-array electrochemiluminescence biomarker assay reader (MSD- MESO SECTOR S 600), manufactured by Meso Scale Discovery (MSD; Rockville, Maryland, USA). This system that provides highly sensitive measurements of molecules in biological samples from mouse, rat, porcine, rabbit, canine, non-human primate, and human, including but not limited to whole blood, serum, plasma, urine, feces, cell or tissue lysates. Biomarkers are assayed in a multiplex format. The underlying technology couples electrochemiluminescent technology and immunobioassay arrays for highly sensitive detection of proteins or peptides for the identification of biomarkers. The requested device will support 6 Major Users with VA funding (I01 BX004146, I01 BX003282, I01 BX003004, I01 BX 003687, I01 BX000760, IK2 BX003838, IK2 CX001095, VA CSP 588, VA NCI NAVIGATE). Identified major users are listed in Key Personnel. In addition to the VA projects supported by the requested equipment, Major and Minor Users benefitting from the acquisition are funded by NIH Awards (R01 DK054921, R01 DK100281, R01 NS108686, R01 NS092093, R01 NS086074, NIH “All Of Us” Program), Department of Defense awards (DOD CA150262, W81XWH), private foundation (Alzheimer’s Association AARGD-17-50549) and 5 awards administered by the Center for Veterans Research & Education (CVRE), our VA-affiliated nonprofit.

我们要求购买多阵列电化学生物标志物测定读取器（MSD- Meso Sector S 600），由Meso Scale Discovery（MSD； Rockville，Maryland，USA）制造。这个系统 从小鼠，大鼠，猪，兔， 犬，非人类灵长类动物和人类，包括但不限于全血，血清，血浆，尿液，粪便， 细胞或组织裂解物。生物标志物以多重格式分配。基础技术夫妇 电化学发光技术和免疫测定阵列，用于高度敏感的蛋白质或 鉴定生物标志物的肽。 请求的设备将为6个主要用户提供VA资金（I01 BX004146，I01 BX003282，I01 BX003004， I01 BX 003687，I01 BX000760，IK2 BX003838，IK2 CX001095，VA CSP 588，VA NCI导航）。确定 主要用户在关键人员中列出。 除了请求的设备支持的VA项目外，主要用户和未成年人受益 此次收购由NIH奖项（R01 DK054921，R01 DK100281，R01 NS108686，R01 NS092093， R01 NS086074，NIH“我们所有人”计划），国防部奖项（DOD CA150262，W81XWH），私人 基金会（阿尔茨海默氏症协会AARGD-17-50549）和5个由退伍军人中心管理的奖项 研究与教育（CVRE），我们的VA附属非营利组织。