ShEEP Acquisition for a LICOR Pearl Trilogy Small Animal Imaging System

我们正在通过研究下的共享设备评估计划(SEEP)申请资金 由研发办公室提供的设备管理课程，以获得LICE-CORE 珍珠三部曲小动物成像白金系统(美国内布拉斯加州林肯制造，GSA合同 编号GS-07F-240CA)。这一全面的成像系统使研究人员能够测量近红外 活体动物、组织和体外分子分析中的荧光和生物发光光学探针。这个 系统以高分辨率获取图像，从而能够研究 相关的生理背景。所需设备的成像能力足够敏感， 想象深层次的目标，如大脑或骨组织。目前，这项技术在 明尼阿波利斯VAHCS，我们的设施也没有任何其他具有同等能力的设备。这个 申请的设备将存放在明尼阿波利斯VAHCS内的一个共享的专用程序室 兽医股，并将作为共同服务设备提供给退伍军人管理局的调查人员。 所要求的成像系统将补充现有的基于多用户的仪器库存 最终目标是提高效率和资源，同时促进转化性(从桌面到床边)研究。 塔米·巴特里克博士将在明尼阿波利斯的全力支持下监督设备的培训和使用 VAHCS主任(Patrick J.Kelly先生)，研究与发展委员会主席(Ronald Bach博士)，以及 威斯康辛州立大学的兽医(马修·拉塞特医生)。主要用户组和次要用户组对此感兴趣的领域 设备跨越多个退伍军人管理局研究学科，共同代表基础和转化性 在老龄化、心血管疾病、癌症、神经科学、干细胞疗法、海湾战争等领域的研究 疾病和肥胖。已确定的退伍军人管理局资助的主要用户将至少占仪器的75% 容量。次要用户组将占用25%或更少的仪器容量。如果明尼阿波利斯VAHCS 将继续成为退伍军人管理局系统中最大和最活跃的研究项目之一，这对我们的 调查人员可以接触到最新一代的高灵敏度、高分辨率仪器。这个 收购Li-COR珍珠铂金系统将加快和提高研究人员的速度 来自多个学科的人员可以获取、分析、显示和理解数据，长期目标是 惠及美国退伍军人独特的医疗保健需求。我们相信，购买这台设备 将增强和扩展我们设施中正在进行的研究的临床相关性，并将产生新的 合作努力开发与卫生保健需求有关的疾病的治疗或治疗方法 向退伍军人和普通民众致敬。

We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development to acquire a LI-COR Pearl Trilogy Small Animal Imaging Platinum System (manufactured in Lincoln, Nebraska USA, GSA contract number GS-07F-240CA). This comprehensive imaging system allows investigators to measure near-infrared fluorescent and bioluminescent optical probes in live animals, tissue, and in vitro molecular assays. The system acquires images at a high resolution, allowing the study of complex biological interactions within a relevant physiological context. The imaging capabilities of the requested equipment are sensitive enough to visualize deep targets such as brain or bone tissue. Currently, this technology is not available at the Minneapolis VAHCS, nor does our facility have any other equipment with equivalent capabilities. The requested equipment will be housed in a shared dedicated procedure room within the Minneapolis VAHCS Veterinary Medical Unit (VMU), and will be made available to VA investigators as common service equipment. The requested imaging system will compliment an existing inventory of multiuser based instruments with the end goal of increasing efficiency and resources while fostering translational (bench-top to bed-side) research. Dr. Tammy Butterick will oversee the training and usage of the equipment under the full support of Minneapolis VAHCS Director (Mr. Patrick J. Kelly), the Research & Development Committee Chair (Dr. Ronald Bach), and the VMU veterinarian (Dr. Matthew Rassette). The fields of interest of major and minor user groups for this equipment span multiple VA research disciplines, and collectively represent both basic and translational research in areas such as aging, cardiovascular disease, cancer, neuroscience, stem cell therapies, Gulf War Illness, and obesity. The identified VA funded major users will account for at least 75% of the instrument capacity. The minor users group will occupy 25% or less of the instrument capacity. If the Minneapolis VAHCS is to remain one of the largest and most active research programs in the VA system, it is critical for our investigators to gain access to the newest generation of high-sensitivity, high-resolution instruments. The acquisition of the LI-COR Pearl Platinum System would accelerate and enhance the rate in which researchers from multiple disciplines can acquire, analyze, display, and understand data, with the long-term goal of benefiting the unique health care needs of US Veterans. We are confident that acquisition of this equipment will enhance and extend the clinical relevance of ongoing investigations in our facility, and will generate new collaborative efforts to develop treatments or therapies for diseases relevant to the health care needs of Veterans and to the general public.