Sheep Request for Baker Ruskinn SCI-tive Hypoxia Workstation

绵羊请求 Baker Ruskinn SCI-tive 缺氧工作站

基本信息

  • 批准号:
    9796661
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-01-01 至 2019-09-30
  • 项目状态:
    已结题

项目摘要

We are requesting funds through the Shared Equipment Evaluation Program (ShEEP) under the Research Equipment Management program offered by the Office of Research and Development to acquire a Baker Ruskinn SCI-tive Dual Asymmetrical Hypoxia Workstation. This workstation supports in vitro experiments with precise control of oxygen concentration ranging from 0.1% (anoxia) to 20.9% (ambient) in 0.1% increments. This allows researchers to grow cells in physiologically relevant conditions, which differ between tissue types. Additionally, this workstation can be used to create in vitro models of hypoxia (low oxygen) or anoxia (no oxygen) in various tissue types. This is critical for the study of heart disease, stroke, and limb ischemia, all of which affect the Veteran patient population. We are requesting a dual workstation, which will allow us to maintain two independently controlled atmospheres simultaneously. Each workstation environment is large enough to work in comfortably, so that entire experiments can be conducted in the controlled environment without being influenced by temporary exposure to room air. This system also includes an inverted microscope to monitor cells under these controlled conditions without removing them from the controlled environment. Currently, this technology is not available at the Minneapolis VAHCS, nor does our facility have any other equipment with equivalent capabilities. The requested equipment will be housed in a shared dedicated instrument room within the Minneapolis VAHCS Research Wing within the main hospital building, and will be made available to VA investigators as common service equipment. The requested hypoxia workstation will compliment an existing inventory of multiuser based instruments with the end goal of increasing efficiency and resources while fostering translational (bench-top to bed-side) research. Dr. Edward McFalls will oversee the training and usage of the equipment under the full support of Minneapolis VAHCS Director (Mr. Darwin Goodspeed) and the Research & Development Committee Chair (Dr. Ronald Bach). The fields of interest of major and minor user groups for this equipment span multiple VA research disciplines, and collectively represent both basic and translational research in areas such as aging, cardiovascular disease, cancer, neuroscience, stem cell therapies, Gulf War Illness, and obesity. The identified VA funded major users will account for at least 75% of the instrument capacity. The minor users group will occupy 25% or less of the instrument capacity. If the Minneapolis VAHCS is to remain one of the largest and most active research programs in the VA system, it is critical for our investigators to gain access to high-quality, robust instruments that represent the gold-standard in the field. The acquisition of the SCI-tive Hypoxia Workstation would accelerate and enhance the rate in which researchers from multiple disciplines can acquire, analyze, display, and understand data, with the long-term goal of benefiting the unique health care needs of US Veterans. We are confident that acquisition of this equipment will enhance and extend the clinical relevance of ongoing investigations in our facility and will generate new collaborative efforts to develop treatments or therapies for diseases relevant to the health care needs of Veterans and to the general public.
我们正在通过研究项目下的共享设备评估计划(ShEEP)申请资金。 设备管理计划由研究和发展办公室提供,以获得一个贝克 Ruskinn SCI-tive双重不对称缺氧工作站。该工作站支持体外实验, 精确控制氧浓度,范围从0.1%(缺氧)到20.9%(环境),增量为0.1%。这 允许研究人员在生理相关条件下培养细胞,这些条件因组织类型而异。 此外,该工作站可用于创建缺氧(低氧)或缺氧(无氧)的体外模型 在不同的组织类型中。这对于心脏病、中风和肢体缺血的研究至关重要,所有这些都会影响 退伍军人患者群体。我们要求一个双工作站,这将使我们能够保持两个 同时独立控制大气层。每个工作站环境都足够大,可以在其中工作 舒适,因此整个实验可以在受控环境中进行而不受影响 暂时暴露在室内空气中该系统还包括一个倒置显微镜,以监测细胞下, 这些受控条件,而不将它们从受控环境中移除。目前,这项技术在 明尼阿波利斯VAHCS不提供,我们的设施也没有任何其他具有同等功能的设备 能力的所要求的设备将安置在 明尼阿波利斯VAHCS研究翼内的主要医院大楼,并将提供给VA 调查员作为共同事务装备。所要求的低氧工作站将补充现有的 多用户工具清单,最终目标是提高效率和资源,同时促进 转化(bench-top to bed-side)研究。爱德华·麦克福尔博士将监督培训和使用的 在明尼阿波利斯VAHCS主任(达尔文古德斯皮德先生)和研究和 发展委员会主席(罗纳德巴赫博士)。主要和次要用户组对此感兴趣的领域 设备跨越多个VA研究学科,共同代表基础研究和转化研究 在老龄化、心血管疾病、癌症、神经科学、干细胞疗法、海湾战争疾病等领域, 肥胖确定的VA资助的主要用户将占仪器容量的至少75%。未成年人 用户群将占仪器容量的25%或更少。如果明尼阿波利斯VAHCS仍然是 作为VA系统中最大和最活跃的研究项目,我们的研究人员获得访问权限至关重要 到代表该领域黄金标准的高质量、坚固耐用的仪器。收购SCI-tive 低氧工作站将加速和提高来自多个学科的研究人员的速度, 获取,分析,显示和理解数据,长期目标是使独特的医疗保健受益 美国退伍军人的需要。我们相信,购买这一设备将加强和扩大临床 我们的设施正在进行的调查的相关性,并将产生新的合作努力, 与退伍军人和公众的医疗保健需求相关的疾病的治疗或疗法。

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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EDWARD O. MCFALLS其他文献

EDWARD O. MCFALLS的其他文献

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{{ truncateString('EDWARD O. MCFALLS', 18)}}的其他基金

Surgical Revascularization's Impact on Hibernating Myoacrdium
血运重建手术对冬眠心肌的影响
  • 批准号:
    9357365
  • 财政年份:
    2010
  • 资助金额:
    --
  • 项目类别:
Mitochondrial Protection Within Chronically Ischemic Myocardium
慢性缺血心肌内的线粒体保护
  • 批准号:
    7851337
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
Mitochondrial Protection Within Chronically Ischemic Myocardium
慢性缺血心肌内的线粒体保护
  • 批准号:
    7578495
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
顿挫心肌与冬眠心肌的区域 FDG 摄取
  • 批准号:
    2655257
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
顿挫心肌与冬眠心肌的区域 FDG 摄取
  • 批准号:
    2332524
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
顿挫心肌与冬眠心肌的区域 FDG 摄取
  • 批准号:
    2229367
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
顿挫心肌与冬眠心肌的区域 FDG 摄取
  • 批准号:
    2872908
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:
REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
顿挫心肌与冬眠心肌的区域 FDG 摄取
  • 批准号:
    6151252
  • 财政年份:
    1996
  • 资助金额:
    --
  • 项目类别:

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全球空气污染暴露模式对大脑老化影响的绘制
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极端天气、空气污染和老龄化女性中风
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