Worldwide Mapping of Air Pollution Exposure Patterns on Aging Brain Health
全球空气污染暴露模式对大脑老化影响的绘制
基本信息
- 批准号:10412874
- 负责人:
- 金额:$ 66.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-06 至 2027-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdverse effectsAffectAgeAgingAirAir PollutionAlzheimer&aposs DiseaseAlzheimer&aposs disease riskAmmoniumAnisotropyArchitectureAreaBiologicalBlood CirculationBrainBrain InjuriesBrain StemBrain regionCarbon BlackChemicalsChildChronicCountryData ScienceData SetDetectionDevelopmentDiffuseDiffusionDiffusion Magnetic Resonance ImagingDiseaseDistressDustElderlyEnvironmentEpidemiologyExposure toGeneticGenotypeGeographyHealthHeterogeneityHippocampus (Brain)IncomeIndividualInfrastructureInsula of ReilInternationalInvestigationKnowledgeLifeLife Cycle StagesLiteratureLongevityMachine LearningMagnetic Resonance ImagingMapsMeta-AnalysisMethodsModelingMorphologyNerve DegenerationNeurosciencesNitratesNitrogen DioxideOutcomeOxidative StressParticipantPathologicPathway interactionsPatternPopulationPredispositionPsyche structureRadialReflex actionReproducibilityResearchRespirationRiskRisk FactorsSamplingSeaSodium ChlorideStatistical ModelsStructureSulfateSurfaceSystemThickTrainingage effectage relatedaging brainambient air pollutionbasebiological adaptation to stressbiopsychosocial factorbrain abnormalitiesbrain healthbrain shapecohortdata harmonizationdesignfine particlesgray matterhigh dimensionalityimmune functionlarge scale datamultidisciplinaryneuroimagingneuroinflammationneurotoxicneurotoxicitypollutantpre-clinicalresponsesexstressorwhite matterworking group
项目摘要
PROJECT ABSTRACT
Exposure to outdoor air pollution (AP) is a risk factor for “accelerated” aging and Alzheimer’s disease, but very
few studies have used neuroimaging to define the mechanistic underpinnings of these relationships. Existing
studies are further limited by the confluence of biopsychosocial factors that have been shown to modify systemic
health consequences of air pollution but have not been modeled in studies of the brain. Finally, the lack of
geospatial diversity in existing studies of air pollution and aging brain health raises numerous questions about
the generalizability of existing neuroimaging findings that predominantly come from high-income countries with
“low” annual levels of exposure. This proposal is designed to address these challenges and limitations through
a new environmental working group within the ENIGMA consortium – ENIGMA-Environment – consisting of 46
individual cohorts from 21 countries. In this proposal we leverage unprecedented geospatial diversity to 1.
Identify and characterize adverse effects of NO2, PM2.5 mass, and PM2.5 components on structural and
diffusion MRI metrics in older adults, 2) Define and explain interactions between NO2, PM2.5, and BPS factors
that underlie neurodegeneration in older adults, and 3) Determine the impact of NO2 and PM2.5 on gray and
white matter trajectories across the lifespan. Outcomes will provide the first translatable model of AP
neurotoxicity in the context of BPS variables, providing a transformative framework for enhanced
detection of individuals at risk for “accelerated” brain aging and AD.
项目摘要
暴露于室外空气污染(AP)是“加速”衰老和阿尔茨海默病的危险因素,但非常
很少有研究使用神经成像来定义这些关系的机械基础。现有
生物心理社会因素的汇合进一步限制了研究,这些因素已被证明可以改变系统性
空气污染对健康的影响,但尚未在大脑研究中建模。最后,缺乏
现有的空气污染和大脑健康老化研究中的地理空间多样性提出了许多问题,
现有神经影像学结果的普遍性,主要来自高收入国家,
年度“低”暴露水平。本提案旨在通过以下方式应对这些挑战和限制
ENIGMA联盟内的一个新的环境工作组- ENIGMA-Environment -由46名成员组成
来自21个国家的单个队列。在这项提案中,我们利用前所未有的地理空间多样性,以1。
确定和表征NO2、PM2.5质量和PM2.5组分对结构和
老年人的扩散MRI指标,2)定义并解释NO2、PM2.5和BPS因素之间的相互作用
3)确定NO2和PM2.5对老年人神经退行性疾病的影响,
白色物质在整个生命周期中的轨迹。成果将提供第一个可翻译的AP模型
在BPS变量的背景下,神经毒性,为增强
检测处于“加速”脑老化和AD风险中的个体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lauren E. Salminen其他文献
Deep transfer learning of brain shape morphometry predicts Body Mass Index (BMI) in the UK Biobank
大脑形状形态测量的深度迁移学习可预测英国生物银行的体重指数 (BMI)
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
L. Zeng;C. Ching;Zvart Abaryan;S. Thomopoulos;Kai Gao;A. Zhu;A. Ragothaman;Faisal M. Rashid;Marc Harrison;Lauren E. Salminen;Brandalyn C. Riedel;N. Jahanshad;D. Hu;P. Thompson - 通讯作者:
P. Thompson
S003329171900093Xjra 1020..1031
S003329171900093Xjra 1020..1031
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Leonardo Tozzi;Lisa Garczarek;Deborah Janowitz;Dan J. Stein;Katharina Wittfeld;Henrik Dobrowolny;Jim Lagopoulos;Sean N. Hatton;Ian B. Hickie;Angela Carballedo;Samantha J. Brooks;Daniella Vuletic;Anne Uhlmann;Ilya M. Veer;Henrik Walter;Robin Bülow;Henry Völzke;Johanna Klinger;Knut Schnell;D. Schoepf;Dominik Grotegerd;Nils Opel;Udo Dannlowski;Harald Kugel;Elisabeth Schramm;C. Konrad;Tilo Kircher;Dilara Jüksel;Igor Nenadi;Axel Krug;Tim Hahn;O. Steinsträter;Ronny Redlich;Dario Zaremba;Bartosz Zurowski;C. H. Y. Fu;Danai Dima;James Cole;Hans J. Grabe;Colm G. Connolly;Tony T. Yang;Tiffany C. Ho;Kaja Z. LeWinn;Meng Li;Nynke A. Groenewold;Lauren E. Salminen;M. Walter;Alan N. Simmons;T. G. V. Erp;Neda Jahanshad;Bernhard T. Baune;N. J. V. D. Wee;Marie;Brenda W. J. H. Penninx;Derrek P. Hibar;P. M. Thompson;Dick J. Veltman;Lianne Schmaal;Thomas Frodl - 通讯作者:
Thomas Frodl
Hippocampal subfield volumes are uniquely affected in PTSD and depression: International analysis of 31 cohorts from the PGC-ENIGMA PTSD Working Group
海马亚区体积在 PTSD 和抑郁症中受到独特影响:对 PGC-ENIGMA PTSD 工作组 31 个队列的国际分析
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Lauren E. Salminen;P. Sämann;Yuanchao Zheng;E. Dennis;Emily K. Clarke;N. Jahanshad;J. E. Iglesias;C. Whelan;S. Bruce;J. Hayes;S. Seedat;C. Averill;Lee A. Baugh;J. Bomyea;Joanna K. Bright;C. Buckle;Kyle Choi;N. Davenport;R. Davidson;M. Densmore;S. Disner;S. du Plessis;J. Elman;N. Fani;G. Forster;C. Franz;J. Frijling;A. Gonenç;S. Gruber;D. Grupe;Jeffrey P. Guenette;C. Haswell;D. Hofmann;M. Hollifield;B. Hosseini;Anna R. Hudson;J. Ipser;T. Jovanović;Amy Kennedy;M. Kennis;A. King;Philipp Kinzel;S. Koch;I. Koerte;Sheri M. Koopowitz;M. Korgaonkar;W. Kremen;J. Krystal;L. Lebois;I. Levy;M. Lyons;V. Magnotta;A. Manthey;S. Nakahara;L. Nawijn;R. Neufeld;J. Nitschke;D. O'Doherty;R. Paul;Matthew Peverill;Faisal M. Rashid;K. Ressler;A. Roos;C. Schmahl;M. Sheridan;A. Sierk;A. Simmons;J. Simons;Raluca M. Simons;M. Stein;Jennifer S Stevens;B. Suarez;J. Théberge;K. Thomaes;S. Thomopoulos;L. L. van den Heuvel;S. V. D. van der Werff;T. V. van Erp;S. V. van Rooij;M. van Zuiden;T. Varkevisser;R. Vermeiren;T. Wager;H. Walter;Xin Wang;S. Winternitz;J. Wolff;Kristen M. Wrocklage;Xi Zhu;C. Ching;T. Gurholt;U. Haukvik;I. Agartz;C. Abdallah;R. Bryant;J. Daniels;M. Debellis;Kelene A. Fercho;E. Geuze;I. Harpaz;J. Herzog;M. Kaufman;J. Lagopoulos;R. Lanius;K. McLaughlin;S. Mueller;Y. Neria;M. Olff;K. Phan;M. Shenton;S. Sponheim;Dan J Stein;T. Straube;N. J. van der Wee;D. Veltman;P. Thompson;R. Morey;M. Logue - 通讯作者:
M. Logue
Cortical microstructural associations with CSF amyloid and pTau
皮质微结构与脑脊液淀粉样蛋白和 pTau 的关联
- DOI:
10.1038/s41380-023-02321-7 - 发表时间:
2023 - 期刊:
- 影响因子:11
- 作者:
T. Nir;J. Villalon;Lauren E. Salminen;E. Haddad;Hong Zheng;S. Thomopoulos;C. Jack;M. Weiner;P. Thompson;N. Jahanshad - 通讯作者:
N. Jahanshad
Big Data Initiatives in Psychiatry: Global Neuroimaging Studies
精神病学大数据计划:全球神经影像研究
- DOI:
10.1007/978-3-030-35206-6_21 - 发表时间:
2020 - 期刊:
- 影响因子:6.8
- 作者:
P. Thompson;C. Ching;E. Dennis;Lauren E. Salminen;J. Turner;T. Erp;N. Jahanshad - 通讯作者:
N. Jahanshad
Lauren E. Salminen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lauren E. Salminen', 18)}}的其他基金
Worldwide Mapping of Air Pollution Exposure Patterns on Aging Brain Health
全球空气污染暴露模式对大脑老化影响的绘制
- 批准号:
10697354 - 财政年份:2022
- 资助金额:
$ 66.26万 - 项目类别:
Impact of Genetic Risk for Increased Oxidative Stress on Brain Integrity
氧化应激增加的遗传风险对大脑完整性的影响
- 批准号:
9071280 - 财政年份:2015
- 资助金额:
$ 66.26万 - 项目类别:
Impact of Genetic Risk for Increased Oxidative Stress on Brain Integrity
氧化应激增加的遗传风险对大脑完整性的影响
- 批准号:
8908833 - 财政年份:2015
- 资助金额:
$ 66.26万 - 项目类别:
相似海外基金
Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence
青春期早期饮酒的前瞻性预测因素的鉴定
- 批准号:
10823917 - 财政年份:2024
- 资助金额:
$ 66.26万 - 项目类别:
Socio-Emotional Characteristics in Early Childhood and Offending Behaviour in Adolescence
幼儿期的社会情感特征和青春期的犯罪行为
- 批准号:
ES/Z502601/1 - 财政年份:2024
- 资助金额:
$ 66.26万 - 项目类别:
Fellowship
Cognitive and non-cognitive abilities and career development during adolescence and adult development: from the perspective of genetic and environmental structure
青春期和成人发展期间的认知和非认知能力与职业发展:从遗传和环境结构的角度
- 批准号:
23K02900 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Reasoning about Spatial Relations and Distributions: Supporting STEM Learning in Early Adolescence
空间关系和分布的推理:支持青春期早期的 STEM 学习
- 批准号:
2300937 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Continuing Grant
Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors
青春期的社会动机是否可以差异预测童年威胁暴露对自杀想法和行为的影响
- 批准号:
10785373 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Mapping the Neurobiological Risks and Consequences of Alcohol Use in Adolescence and Across the Lifespan
绘制青春期和整个生命周期饮酒的神经生物学风险和后果
- 批准号:
10733406 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence
睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用
- 批准号:
10676403 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Thalamo-prefrontal circuit maturation during adolescence
丘脑-前额叶回路在青春期成熟
- 批准号:
10585031 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Interdisciplinary Perspectives on the Politics of Adolescence and Democracy
青少年政治与民主的跨学科视角
- 批准号:
EP/X026825/1 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Research Grant
An Empirical Study on the Influence of Socioeconomic Status in Adolescence on Exercise Habits in Adulthood
青春期社会经济地位对成年期运动习惯影响的实证研究
- 批准号:
23K16734 - 财政年份:2023
- 资助金额:
$ 66.26万 - 项目类别:
Grant-in-Aid for Early-Career Scientists