Core B - Pathology and Biospecimen Core
核心 B - 病理学和生物样本核心
基本信息
- 批准号:9792054
- 负责人:
- 金额:$ 34.43万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-04-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AftercareAntibodiesApplications GrantsAutopsyBiologicalBiopsyBloodCancer CenterCancer ModelCell LineCellsCellularityCholangiocarcinomaClinicalClinical DataClinical TrialsCollaborationsComplementConsentDevelopmentEnrollmentEnsureEvaluationFutureGastrointestinal NeoplasmsGenerationsGenomicsGoalsHumanImage AnalysisImmuneImmunofluorescence ImmunologicInfrastructureInstitutional Review BoardsLinkMaintenanceMalignant neoplasm of gastrointestinal tractMicroscopicModelingMolecularMolecular AnalysisMusOrganoidsPathologicPathologyPatientsPerformancePopulationPre-Clinical ModelProceduresProcessProteinsProtocols documentationQuality ControlResearchResearch PersonnelResearch Project GrantsResearch SupportResourcesRoleSamplingServicesSliceSpecimenStainsStandardizationTechniquesTechnologyTissue imagingTissuesTrastuzumabValidationWorkXenograft procedurebasecareercellular imagingdrug testinggastrointestinalhuman modelhuman tissueimprovedin vivoinhibitor/antagonistlaser capture microdissectionliquid biopsymetastatic processmodel developmentmolecular pathologymouse modelneoplasticnew technologynovelnovel therapeutic interventionpre-clinicalpre-clinical researchpreclinical studypreclinical trialprogramsrepositorysuccesstooltool developmenttumor
项目摘要
Project Summary
The acquisition, pathologic analysis and molecular characterization of human and mouse model
gastrointestinal (GI) samples is an integral requirement for all portions of this SPORE. This
Core will continue to provide SPORE investigators multiple pathology services to support
Research Projects and future Career Enhancement Program (CEP) and Developmental
Projects (DP) awardees. We will work in close collaboration with investigators to achieve three
crucial purposes: i) to provide tissue specimens and pathology expertise to evaluate human and
mouse models of GI neoplasms; ii) to provide molecular pathologic expertise in state-of-the-art
molecular evaluation of tissue specimens; and iii) to evaluate and implement new tissue and
cellular imaging and analysis technologies that will benefit these research goals in the future.
Centralization of Core activities builds upon established infrastructure and expertise of these
investigators, and complements but does not replicate existing infrastructure in our Cancer
Center and provides a valuable component to the analysis of biological resources developed
and utilized by SPORE investigators. To bring pathology based scientific support to all SPORE
projects, this Core proposes the following specific aims:
Specific Aim 1: To provide human biospecimen procurement and distribution.
Specific Aim 2: Generation of models for pre-clinical trials
Specific Aim 3: Pathologic characterization of human and mouse GI tumors using molecular
pathology tools and emerging new technologies
项目摘要
人和小鼠模型的获得、病理分析和分子特征
胃肠道(GI)样本是本SPORE所有部分不可或缺的要求。这
核心将继续为SPORE研究者提供多种病理学服务,以支持
研究项目和未来的职业提升计划(CEP)和发展
项目(DP)获奖者。我们将与调查人员密切合作,
关键目的:i)提供组织标本和病理学专业知识,以评估人类和
胃肠道肿瘤的小鼠模型; ii)提供最先进的分子病理学专业知识
组织样本的分子评价;和iii)评价和实施新的组织和
细胞成像和分析技术,将有利于这些研究目标的未来。
核心活动的集中化建立在这些机构的既定基础设施和专门知识之上。
研究人员,并补充,但不复制现有的基础设施,在我们的癌症
中心,并提供了一个有价值的组成部分,分析生物资源的发展
并由SPORE调查人员使用。为所有SPORE提供基于病理学的科学支持
本核心文件提出了以下具体目标:
具体目标1:提供人体生物标本的采购和分发。
具体目标2:生成用于临床前试验的模型
特定目的3:使用分子生物学方法对人和小鼠GI肿瘤进行病理学表征
病理学工具和新兴技术
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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